Abstract: The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

Abstract: This invention provides a valve for a flowable material. The valve has a body defining a bore defined therein. An opening is defined in the side of the bore for material to flow from the bore. The valve also has an actuatable member which is movable along the bore to control the extent of an uncovered area of the opening defined in the bore to control the flow of material through the opening.

Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

Abstract: The present invention relates to a tap assembly for dispensing fluids from a flexible film bag such as a “bag-in-box”. Known taps associated with such flexible bags do not efficiently dispense fluid from a bag which is partially collapsed and/or can damage the opposite wall of the partially collapsed bag. The tap assembly includes a body with a bore, an actuation member to cover at least a portion of the bore and a piercer which is configured to pivot within the bore and pierce and cut a sterility membrane positioned over an open end of the bore upon movement of the actuation member by a user. The piercer comprises a curved surface which functions to position the piercer away from the plane of the adjacent bag wall after initial piercing.

Abstract: Known fluid dispensers can suffer from the disadvantage of inadvertent disconnection of a connector causing potentially hazardous spillage of fluid. The present invention relates to a fluid dispensing assembly comprising a tap and a connector body. The tap comprises a first valve, movable between an open and closed position to allow fluid flow through; and a first portion of an interlocking coupling, configured for rotational engagement with a second complementary interlocking coupling portion of the connector body by rotation about a first fluid dispensing assembly axis. The connector body also comprises a second valve, movable between an open and closed position to allow fluid flow through. By this configuration, the first and second interlocking coupling portions remain interlocked preventing disconnection of the connector body from the tap unless the first and second valves are both in the closed position.

Abstract: A female contact comprising two opposing elongated blades pivotally connected defining a gap there between to receive a male prong, the blades having at least one angularly directed extension resiliently engaging a shaped surface configured to regulate restraining forces on a male prong during insertion, retention and extraction from the gap, thereby self activating an abrupt release of the prong in response to a predetermined extraction force applied in a substantial range of lateral angles.

Abstract: An electrical receptacle and junction box apparatus including a stud mounted electrical junction box with stud-attaching screw shoulders having wire apertures with retaining screws and retaining screw fittings for each wire aperture for receiving electrical wiring without wrapping the wiring around screws, a ground strip, a slide-in receptacle or slide-in switch received in the electrical junction box, an electrical connection between the electrical junction box and the slide-in receptacle or slide-in switch unit with elongated prongs, slotted terminals with slot apertures to allow the slide-in receptacle or slide-in switch to move in and out of the electrical junction box and non-conductive bases for embedding the terminals, the ground strip and the retaining screw fittings.

Abstract: A heating unit (2) for heating a patio (4), which heating unit (2) comprises a heater portion (8) which provides heat for the patio (4) by burning gas from a gas container (6), and a meter (10), and the heating unit (2) being such that the meter (10) is a token-operated or coin-operated meter which allows the passage of gas from the gas container (6) to the heater portion (8) on receipt of at least one token (12) or coin, and the passage of the gas is only for a predetermined time period after which at least one further token (12) or coin is required for allowing the passage of more of the gas for a further predetermined time period.

Abstract: This invention provides a valve for a flowable material. The valve has a body defining a bore defined therein. An opening is defined in the side of the bore for material to flow from the bore. The valve also has an actuatable member which is movable along the bore to control the extent of an uncovered area of the opening defined in the bore to control the flow of material through the opening.

Abstract: This invention provides an attachment for mounting electromagnetic identification tags onto the necks of bottles. The tag has a portion which provides a receptacle portion for an RFI tag. This receptacle portion is connected to a portion that embraces a neck of a bottle to attach the receptacle portion, and thereby, the RFID tag to the neck of the bottle. The identification tag may be formed from a material that does not interfere with electromagnetic signals.

Abstract: An electrical receptacle and junction box apparatus including a stud mounted electrical junction box with stud-attaching screw shoulders having wire apertures with retaining screws and retaining screw fittings for each wire aperture for receiving electrical wiring without wrapping the wiring around screws, a ground strip, a slide-in receptacle or slide-in switch received in the electrical junction box, an electrical connection between the electrical junction box and the slide-in receptacle or slide-in switch unit with elongated prongs, slotted terminals with slot apertures to allow the slide-in receptacle or slide-in switch to move in and out of the electrical junction box and non-conductive bases for embedding the terminals, the ground strip and the retaining screw fittings.

Abstract: A valve assembly to avoid or minimise the effect of “compression setting” which occurs when valves control the flow of some hazardous and/or corrosive fluids, especially when at en elevated temperature. The valve assembly includes a valve stem having a head portion which engages with a valve seat in order to close and seal the valve and an elastically deformable portion. In order to allow fluid to flow through the valve, the elastically deformable portion of the valve stem is deformed to allow fluid to pass between the head portion and the valve seat. An additional biasing element such as a cylindrical or conical compression spring is provided to urge the head portion towards contact with the valve seat. In this way, should “compression setting” of the elastic portion of the valve stem take place, the additional spring will ensure that the valve head is still able to be engaged with the valve seat to thereby close the valve.

Abstract: A valve assembly is designed to avoid or minimise the effect of “compression setting” which occurs when valves control the flow of some hazardous and/or corrosive fluids, especially when at an elevated temperature. The valve assembly includes a valve stem having a head portion which engages with a valve seat in order to close and seal the valve and an elastically deformable portion. In order to allow fluid to flow through the valve, the elastically deformable portion of the valve stem is deformed to allow fluid to pass between the head portion and the valve seat. An additional biasing element such as a cylindrical or conical compression spring is provided to urge the head portion towards contact with the valve seat. In this way, should “compression setting” of the elastic portion of the valve stem take place, the additional spring will ensure that the valve head is still able to be engaged with the valve seat to thereby close the valve.

Abstract: The present invention provides a liquid dispenser which is adapted to connect to a container, the container including a membrane seal, wherein the dispenser is movable between two configurations being an unopened configuration to an open configuration which opens a liquid channel from the liquid dispenser to the container cap, and which pierces the membrane seal to open a liquid channel from the container through to the dispenser. A method of manufacturing such a dispenser is also disclosed.

Abstract: The present invention provides a liquid dispenser which is adapted to connect to a container, the container including a membrane seal, wherein the dispenser is movable between two configurations being an unopened configuration to an open configuration which opens a liquid channel from the liquid dispenser to the container cap, and which pierces the membrane seal to open a liquid channel from the container through to the dispenser. A method of manufacturing such a dispenser is also disclosed.

Abstract: The present invention provides a liquid dispenser which is adapted to connect to a container, the container including a membrane seal, wherein the dispenser is movable between two configurations being an unopened configuration to an open configuration which opens a liquid channel from the liquid dispenser to the container cap, and which pierces the membrane seal to open a liquid channel from the container through to the dispenser. A method of manufacturing such a dispenser is also disclosed.

Abstract: The present invention is capable of engagement with a fluid port and capable of being open to create a fluid path, where the valve assembly includes a valve head for closing a fluid path to a port associated with a valve assembly, and a housing, and at least one engagement element formed integrally with the housing, wherein the valve assembly is characterized in that to open the valve assembly the valve head is driven into an engagement element deforming the valve head and creating the fluid path through the valve assembly.

Abstract: A measure for dispensing measured quantities of two liquors from a pair of bottles has a pair of measuring and receiving bowls associated with the bottles. Sleeves engage within necks of the bottles for delivery of liquid from each bottle to an associated bowl. Valve members in each bowl have normally open inlet liquid seals which cooperate with the sleeves to control filling of the bowls. Outlet liquid seals on the valve members normally close liquid outlets of the bowls. An actuating lever is operable to raise the valve members, moving the seals upwardly for opening the outlets and closing the inlets of the bowls. Thus, liquid measures flow from the bowls substantially concurrently into a glass or the like placed below the liquid outlets. The outlets are arranged to direct the two liquids to opposite sides of the glass so that the liquids remain separated within the glass. Release of the actuating lever drops the valve members closing the liquid outlets and opening the inlets for recharging the bowls.