Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Provided in embodiments of the present invention is a neem oil lotion preparation impregnated in a fabric wipe to enable individualized application of an organic pesticide on human skin or a plant. In one embodiment, a wipe includes a fabric sheet impregnated with neem oil, an emulsifier, an emollient, a preservative, and water. In additional embodiments, the neem oil wipe may further be impregnated with a humectant and a fragrance.

Abstract: Provided in embodiments of the present invention is a water sport garment providing protection from cold water and having an improved access system for entry into or exit from the garment. In one embodiment, the water sport protective garment includes a torso portion, pant-leg portions extending from the torso portion, non-openable sleeve portions extending from the torso portion, and at least one openable seam extending from the torso portion down each of the pant-leg portions such that when the openable seam is opened a section of the torso portion and sections of the leg portions can be displaced to improve access into and egress from the protective garment.