Abstract: A system and method of steering a watercraft. The method comprising determining an estimated speed, an estimated yaw, and an estimated yaw rate of change of a watercraft based on a first output from a GPS and a second output from an inertial measurement unit; adjusting a position of a rudder coupled to a hull of the watercraft based on a position of a steering wheel; determining a desired yaw rate of change of a hull based on the position of the steering wheel and the estimated speed; energizing a propeller to provide a propelling force on the hull; and energizing a thruster coupled to the hull based on an error between the desired yaw rate of change and the estimated yaw rate of change.

Abstract: A method includes receiving a target position for a watercraft; determining a current position and a current heading axis of the watercraft; and determining a position error based on the difference between the target position and the current position. A position error axis is defined between the target position and the current position. The method further includes determining a heading error based on the current heading axis and a desired heading axis. The desired heading axis is orthogonal to the position error axis. The method further includes activating a plurality of thrusters to minimize the heading error; determining when the heading error is less than a threshold; and activating the plurality of thrusters to minimize the position error and the heading error in response to determining the heading error is less than the threshold.

Abstract: Provided herein are CDK inhibitor compounds having a fused 6-6 bicyclic heteroaryl core, such as a naphthyridine, quinazoline, pyridopyrimidine or related isosteric core structure that is further substituted. The core structure can be substituted with an amino group, where the amino group is further substituted with a cyclic group having an appended hydrophilic group. Also provided herein are compositions including the subject CDK inhibitor compounds. In some embodiments, the CDK inhibitor compounds are CDK2 inhibitors, or CDK4 inhibitors. Also provided are methods for using compositions of the disclosure in research or as therapeutics.

Abstract: CDK2 inhibitor compounds having a core structure including a fused 5-6 heteroaryl ring system where the 6-membered ring of the system is a pyridine or pyrimidine, and the 5-membered ring contains at least one nitrogen atom, such as a pyrrole, imidazole or pyrazole ring are provided. The compounds can have a pyrazolopyrimidine core structure having a 6-amino group that is further substituted. The 6-amino group can be linked to a cyclic group having an appended hydrophilic group or substituent. Also provided herein are compositions including the CDK2 inhibitor compounds, and methods for using compounds in research and as therapeutics.

Abstract: A system and method of steering a watercraft. The method comprising determining an estimated speed, an estimated yaw, and an estimated yaw rate of change of a watercraft based on a first output from a GPS and a second output from an inertial measurement unit; adjusting a position of a rudder coupled to a hull of the watercraft based on a position of a steering wheel; determining a desired yaw rate of change of a hull based on the position of the steering wheel and the estimated speed; energizing a propeller to provide a propelling force on the hull; and energizing a thruster coupled to the hull based on an error between the desired yaw rate of change and the estimated yaw rate of change.

Abstract: The present disclosure relates to methods and compositions of genetically engineered microbes, for improved control of pathogens, such as bacteria and/or fungi, with application in various fields, such as pharmaceuticals and agriculture. The genetically engineered microbes may comprise a deletion or knockout at one or more genomic loci, that confers capability of reducing hyphal growth of a fungus, reduce spore formation of a fungus, and/or other benefits.

Abstract: A system and method for receiving an authorization request, the authorization request including a first resource identifier including one or more path segments; processing the resource identifier uniquely identifying a set of resources in the microservice environment by: (a) determining whether a set of permissions is associated with the resource identifier is present in a resource access manager; (b) recording the set of permissions when present; (c) decatenating an end path segment from the resource identifier based on a delimiter; and (d) determining whether no path segments remain in the resource identifier after decatenation of the end segment, wherein (a), (b), (c) and (d) are repeated until it is determined that no path segments remain in the resource identifier; and responsive to determining no path segments remain in the resource identifier, returning an aggregated set of recorded permissions representing the complete set of effective permissions.

Abstract: The present invention provides an inkjet ink comprising 1,10-decanediol diacrylate (DDDA) in combination with at least one of lauryl acrylate and/or 2-(2-vinyloxy ethoxy)ethyl acrylate (VEEA), one or more photoinitiators and optionally a colourant, wherein DDDA is present in 10-45% by weight, based on the total weight of the ink. The inkjet ink of the present invention is suitable for food packaging. The present invention also provides a method of printing the inkjet ink of the present invention.

Abstract: An oracle that is fast enough to publish data to the blockchain in a timely manner while remaining decentralized and robust to the failure of any one part. A blockchain node may receive data to introduce to the blockchain from the oracle, determine whether the data was provided by a primary party or parties designated as an oracle by a DAO. If so, the node may process the data from the one or more primary parties and introduce the processed data to the blockchain.

Abstract: A network function virtualization (NFV) platform can support virtual network functions (VNFs) whose behavior can change during their lifecycles. For example, a VNF manager of the NFV platform can receive a request to update a condition of a VNF and/or an action to perform upon satisfaction of the condition. Based on the condition and action, the VNF manager can create or store a lifecycle management policy in an extensible lifecycle management model associated with the virtual network function. Based on the lifecycle management policy, the VNF manager can monitor the virtual network function to detect satisfaction of the condition and, in response to detecting satisfaction of the condition, the VNF manager can perform the action associated with the lifecycle management policy.

Abstract: A system and method of steering a watercraft. The method comprising determining an estimated speed, an estimated yaw, and an estimated yaw rate of change of a watercraft based on a first output from a GPS and a second output from an inertial measurement unit; adjusting a position of a rudder coupled to a hull of the watercraft based on a position of a steering wheel; determining a desired yaw rate of change of a hull based on the position of the steering wheel and the estimated speed; energizing a propeller to provide a propelling force on the hull; and energizing a thruster coupled to the hull based on an error between the desired yaw rate of change and the estimated yaw rate of change.

Abstract: An oracle that is fast enough to publish data to the blockchain in a timely manner while remaining decentralized and robust to the failure of any one part. A blockchain node may receive data to introduce to the blockchain from the oracle, determine whether the data was provided by a primary party or parties designated as an oracle by a DAO. If so, the node may process the data from the one or more primary parties and introduce the processed data to the blockchain.

Abstract: A method includes receiving a target position for a watercraft; determining a current position and a current heading axis of the watercraft; and determining a position error based on the difference between the target position and the current position. A position error axis is defined between the target position and the current position. The method further includes determining a heading error based on the current heading axis and a desired heading axis. The desired heading axis is orthogonal to the position error axis. The method further includes activating a plurality of thrusters to minimize the heading error; determining when the heading error is less than a threshold; and activating the plurality of thrusters to minimize the position error and the heading error in response to determining the heading error is less than the threshold.

Abstract: The disclosure relates to isolated microorganisms—including novel strains of the microorganisms, microbial consortia, and agricultural compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and agricultural compositions comprising the same, in methods for imparting beneficial properties to target plant species. In particular aspects, the disclosure provides methods of increasing desirable plant traits in agronomically important crop species.

Abstract: The invention relates to new anti-hCD3 antibodies that, in contrast to prior art anti-CD3 antibodies, bind specifically to human CD3 at acidic pH, but do not significantly bind to human CD3 at neutral or physiological pH, methods to produce these antibodies and therapeutic uses of these antibodies. These antibodies are able to activate T cells at acidic pH while having significantly reduced activity at neutral or physiological pH.

Abstract: An oracle that is fast enough to publish data to the blockchain in a timely manner while remaining decentralized and robust to the failure of any one part. A blockchain node may receive data to introduce to the blockchain from the oracle, determine whether the data was provided by a primary party or parties designated as an oracle by a DAO. If so, the node may process the data from the one or more primary parties and introduce the processed data to the blockchain.

Abstract: An apparatus for heating a window of a vehicle comprises an electrical storage unit configured to store an electrical charge and a plurality of heating circuits disposed on a window of the vehicle. The apparatus further comprises a controller configured to monitor the electrical charge of the electrical storage unit and selectively activate one or more of the heating circuits based on the electrical charge.

Abstract: The present invention provides an inkjet ink comprising 1,10-decanediol diacrylate (DDDA) in combination with at least one of lauryl acrylate and/or 2-(2-vinyloxy ethoxy)ethyl acrylate (VEEA), one or more photoinitiators and optionally a colourant, wherein DDDA is present in 10-45% by weight, based on the total weight of the ink. The inkjet ink of the present invention is suitable for food packaging. The present invention also provides a method of printing the inkjet ink of the present invention.

Abstract: A golf device for providing an interface for users to hand grip and stroke a putter is disclosed. The device may include a single hand grip, a split hand grip, or interchangeable geometries configured to allow the user to hold the putter in an individualized manner best-suited for producing a reliable, reproducible putting stroke.

Abstract: The invention relates to new anti-hCD3 antibodies that, in contrast to prior art anti-CD3 antibodies, bind specifically to human CD3 at acidic pH, but do not significantly bind to human CD3 at neutral or physiological pH, methods to produce these antibodies and therapeutic uses of these antibodies. These antibodies are able to activate T cells at acidic pH while having significantly reduced activity at neutral or physiological pH.