Abstract: A medical device including an application device with a first fluid path and a container movably attached to the application device. The container and the application device have a second fluid path therethrough, the container includes an inner chamber that is intermediate proximal and distal portions of the second fluid path, the inner chamber is fluidly isolated from the proximal portion of the second fluid path at a first position of the container, and the inner chamber is fluidly coupled to the proximal and distal portions of the second fluid path at a second position of the container. The first fluid path bypasses the container and the passage of fluid through the first fluid path is separately controllable from the passage of fluid through the second fluid path.

Abstract: A tissue-manipulating system including a tissue-manipulating device having shaft and a tissue grasper assembly. The tissue grasper assembly has at least one grasper arm resiliently expandable from a closed configuration, within and extending along the longitudinal axis of a shaft, to an open configuration outside the shaft with the grasper arm expanded in a direction transverse to the longitudinal axis of the shaft. In the open configuration, the at least one grasper arm may be engaged with tissue wall to manipulate or move the tissue wall, such as to move a distal tissue wall closer to a proximal tissue wall. The tissue grasper assembly may be deployable (such as by being separated from the shaft), such as to remain in place holding two tissue walls in apposition.

Abstract: A clipping system includes a device including longitudinal slots extending through a wall thereof and a clip releasably received within a distal portion of the device. The clip includes a capsule and a pair of clip arms. Proximal ends of the arms are slidably received within the capsule and a collet is slidably mounted over the device movable between an insertion configuration, in which the collet is positioned over the distal portion of the device pressing the distal portion against the capsule and a deployed configuration, in which the collet is proximal of the distal portion so that the clip is releasable from the device. A control member extends through the channel of the device to couple to the proximal ends of the arms and a portion of the collet. Movement of the member opens and closes the clip and moves the collet between the insertion and deployed configurations.

Abstract: A medical device that includes a body configured to store a first substance and a second substance, a shaft extending distally from the body and having a distal end, and a pressure source in fluid communication with the first substance, the second substance, and the shaft. Pressurized medium from the pressure source is configured to deliver the first substance through the shaft and out of the distal end, deliver the second substance through the shaft, separate from the first substance, and out of the distal end, and be delivered through the shaft separate from the first substance and the second substance, and out of the distal end. The pressurized medium mixes the first substance and the second substance externally of the shaft as the first and second substances exit the distal end.

Abstract: A resurfacing device for removing a thin layer of diseased tissue while minimizing damage to the underlying tissue layers may include an expandable scaffold attached to a catheter shaft, at least one electrode disposed on the expandable scaffold, and a plurality of debridement elements disposed on an outer surface of the expandable scaffold. The expandable scaffold is positioned in apposition to the target tissue, the scaffold is expanded and the electrodes are activated to ablate diseased tissue. The scaffold is rotated to remove the ablated tissue.

Abstract: A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: A device for delivering an agent may comprise a chamber for receiving agent through an agent inlet; and a body received within the chamber. The body may be movable in first and second directions along a longitudinal axis of the chamber. In a first configuration of the body, an amount of the agent may flow into the chamber via the agent inlet. In a second configuration of the body, the agent is prevented from flowing into the chamber via the agent inlet. When the body is transitioned from the first configuration to the second configuration, the amount of the agent may be moved from a first position along the longitudinal axis of the chamber to a second position along the longitudinal axis of the chamber.

Abstract: A clipping system includes a device including longitudinal slots extending through a wall thereof and a clip releasably received within a distal portion of the device. The clip includes a capsule and a pair of clip arms. Proximal ends of the arms are slidably received within the capsule and a collet is slidably mounted over the device movable between an insertion configuration, in which the collet is positioned over the distal portion of the device pressing the distal portion against the capsule and a deployed configuration, in which the collet is proximal of the distal portion so that the clip is releasable from the device. A control member extends through the channel of the device to couple to the proximal ends of the arms and a portion of the collet. Movement of the member opens and closes the clip and moves the collet between the insertion and deployed configurations.

Abstract: A tissue-manipulating system including a tissue-manipulating device having shaft and a tissue grasper assembly. The tissue grasper assembly has at least one grasper arm resiliently expandable from a closed configuration, within and extending along the longitudinal axis of a shaft, to an open configuration outside the shaft with the grasper arm expanded in a direction transverse to the longitudinal axis of the shaft. In the open configuration, the at least one grasper arm may be engaged with tissue wall to manipulate or move the tissue wall, such as to move a distal tissue wall closer to a proximal tissue wall. The tissue grasper assembly may be deployable (such as by being separated from the shaft), such as to remain in place holding two tissue walls in apposition.

Abstract: A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: A device for delivering an agent may comprise a chamber for receiving agent through an agent inlet; and a body received within the chamber. The body may be movable in first and second directions along a longitudinal axis of the chamber. In a first configuration of the body, an amount of the agent may flow into the chamber via the agent inlet. In a second configuration of the body, the agent is prevented from flowing into the chamber via the agent inlet. When the body is transitioned from the first configuration to the second configuration, the amount of the agent may be moved from a first position along the longitudinal axis of the chamber to a second position along the longitudinal axis of the chamber.

Abstract: A medical device comprising a housing defining at least one enclosure for storing agent in a first form, a force applicator within the housing and adjacent the enclosure, a drive mechanism for moving the agent toward the force applicator, wherein the force applicator defines a surface for applying a force to the agent to separate the agent into particles smaller than a size of the first form, and wherein the device defines a lumen for receiving the particles from the force applicator and for receiving a pressurized fluid to propel the particles through the lumen.

Abstract: An implantable device having an adjustable passage therethrough. The passage may be adjustable to occlude or otherwise to regulate access or flow of materials therethrough. An elongated element may be inserted into the passage when in a closed configuration to selectively open the passage. For instance, the implantable device may be a tubular device with a twisted region closing the passage therethrough, and the elongated device may be configured to engage such twisted region and to be rotated to untwist the closed region. An additional tubular device with a passage therethrough may be inserted into the passage of the implantable device to hold open the passage for a selected period of time.

Abstract: The present disclosure relates generally to the field of medical devices and medical device delivery. In particular, the present disclosure relates to medical devices, systems, and methods for delivering a barrier device within a body lumen of a patient, such as the GI tract. For example, a barrier device may include a distal self-expanding stent. A tubular barrier may have a proximal end, a distal end, and a lumen extending therethrough. The distal stent may be disposed at the distal end of the tubular barrier. An anchoring self-expanding stent may be disposed at the proximal end of the tubular barrier.

Abstract: A device may be configured to deliver an agent to a target tissue via pressurized fluid and the device may include a catheter including a lumen; an enclosure configured to store an agent, receive a pressurized fluid, and release a combination of the pressurized fluid and the agent; and a valve downstream of the enclosure to receive the combination of the pressurized fluid and the agent from the enclosure. The valve may have a first configuration preventing flow of the combination through the lumen and a second configuration permitting flow of the combination through the lumen.

Abstract: A medical system includes a handle, a sheath extending from the handle, and an end effector connected to a distal end of the sheath, where the end effector directs a mass of material towards a target site of a body and cause release of the material onto the target site.

Abstract: A medical device comprising a housing defining at least one enclosure for storing agent in a first form, a force applicator within the housing and adjacent the enclosure, a drive mechanism for moving the agent toward the force applicator, wherein the force applicator defines a surface for applying a force to the agent to separate the agent into particles smaller than a size of the first form, and wherein the device defines a lumen for receiving the particles from the force applicator and for receiving a pressurized fluid to propel the particles through the lumen.

Abstract: An implantable device having an adjustable passage therethrough. The passage may be adjustable to occlude or otherwise to regulate access or flow of materials therethrough. An elongated element may be inserted into the passage when in a closed configuration to selectively open the passage. For instance, the implantable device may be a tubular device with a twisted region closing the passage therethrough, and the elongated device may be configured to engage such twisted region and to be rotated to untwist the closed region. An additional tubular device with a passage therethrough may be inserted into the passage of the implantable device to hold open the passage for a selected period of time.