Abstract: A delivery device may comprise a sheath configured to be inserted into a body lumen of a patient. The sheath may have a proximal end, a distal end, a first channel extending within the sheath from the proximal end to the distal end, and a second channel extending within the sheath from the proximal end to the distal end. A collective cross-sectional area of the first channel and the second channel may be more than 50% of a total cross sectional area of the sheath. The device may also be comprised of a handle at the proximal end of the sheath, wherein the handle is configured to provide fluid communication between a first port and the first channel and a second port and the second channel.

Abstract: A medical device that includes a body configured to store a first substance and a second substance, a shaft extending distally from the body and having a distal end, and a pressure source in fluid communication with the first substance, the second substance, and the shaft. Pressurized medium from the pressure source is configured to deliver the first substance through the shaft and out of the distal end, deliver the second substance through the shaft, separate from the first substance, and out of the distal end, and be delivered through the shaft separate from the first substance and the second substance, and out of the distal end. The pressurized medium mixes the first substance and the second substance externally of the shaft as the first and second substances exit the distal end.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.

Abstract: Implementations of a delivery device and method are disclosed. One implementation is a delivery device comprising a flow chamber with an inlet port for receiving a fluid flow in the flow chamber, and an outlet port for exiting a material from the flow chamber. The flow chamber may include a formation portion in which a suspension of the material is formed, and a collection portion that directs the suspension toward and/or into the outlet port. An amount of the material may collect in the collection portion adjacent the outlet port. The device may further comprise an insertion port for permitting insertion of the material in the flow chamber, and/or a pusher operable to move the amount of material through the outlet port. Related devices and methods also are disclosed.

Abstract: A resurfacing device for removing a thin layer of diseased tissue while minimizing damage to the underlying tissue layers may include an expandable scaffold attached to a catheter shaft, at least one electrode disposed on the expandable scaffold, and a plurality of debridement elements disposed on an outer surface of the expandable scaffold. The expandable scaffold is positioned in apposition to the target tissue, the scaffold is expanded and the electrodes are activated to ablate diseased tissue. The scaffold is rotated to remove the ablated tissue.

Abstract: In one aspect of the present disclosure, an apparatus for delivering a powdered agent into a subject's body may include a powder chamber housing the powdered agent. The apparatus also may include a chassis in fluid connection with the powder chamber. The chassis may include a first passage for receiving a pressurized gas, a second passage for receiving the powdered agent from the powder chamber, and a junction in fluid communication with the first passage and the second passage. At least a first portion of the pressurized gas is introduced into the powdered agent at the junction to fluidize the powdered agent.

Abstract: A medical device for delivering a material using a pressurized fluid includes an enclosure having a first chamber and a second chamber separated by a membrane, and an outlet, and a pin configured to move within the enclosure between a first position and a second position, where a proximal end of the pin blocks the outlet when the pin is in the first position.

Abstract: A device configured to deliver a pressurized fluid includes a body having an input opening for receiving the pressurized fluid and an output opening for delivering the pressurized fluid, a handle defining a lumen, wherein the lumen is configured to receive a container containing the pressurized fluid, and at least one aperture fluidly connecting the lumen to an atmosphere external of the device.

Abstract: A device for delivering pressurized fluid includes a handle having a lumen configured to receive a container of pressurized fluid, a cap to close the lumen and an indicator to move from a first position to a second position. The first position indicates disconnection of the container from a fluid path, and the second position indicates connection of the container to the fluid path.

Abstract: A tissue-manipulating system including a tissue-manipulating device having shaft and a tissue grasper assembly. The tissue grasper assembly has at least one grasper arm resiliently expandable from a closed configuration, within and extending along the longitudinal axis of a shaft, to an open configuration outside the shaft with the grasper arm expanded in a direction transverse to the longitudinal axis of the shaft. In the open configuration, the at least one grasper arm may be engaged with tissue wall to manipulate or move the tissue wall, such as to move a distal tissue wall closer to a proximal tissue wall. The tissue grasper assembly may be deployable (such as by being separated from the shaft), such as to remain in place holding two tissue walls in apposition.

Abstract: A device for delivering an agent may comprise: a housing defining an enclosure. The housing may be configured to store an agent. The device may further comprise an inlet, in fluid communication with the enclosure, for receiving a flow of pressurized fluid; an outlet in fluid communication with the enclosure; and a filter disposed within the enclosure. Pores of a wall of the filter may be configured such that the fluid is permitted to pass through the pores into a channel defined by an inner surface of the wall. An actuation member may be configured to transition between a first configuration, in which portions of the agent disposed proximally to the actuation member are prevented from passing distally of the actuation member, and a second configuration, in which portions of the agent disposed proximally of the actuation member are capable of passing distally of the actuation member.

Abstract: A medical system includes a source of a material, a first tube, and a second tube. The material is configured to expand and form a porous body after the material is deployed into a body lumen. The first tube is configured to deliver the material into the body lumen, and the second tube is configured to apply suction to the porous body.

Abstract: A medical system including a porous body connected to a distal end of a vacuum tube, and a patch defining a lumen therethrough for accommodating the vacuum tube, where the patch is fluidly seals the porous body from a body lumen when the patch is deployed in a subject.

Abstract: This disclosure relates generally to the field of devices and procedures for forming an opening between adjacent tissue structures. For example, in an embodiment, a system for forming an opening between body lumens may include a delivery catheter. A first access element may be configured to be positioned against a first body lumen disposed about a distal end of the catheter. A second access element having an outer diameter that substantially matches an outer diameter of the first access element may be disposed about the distal end of the catheter. The second access element may be configured to be positioned against a second body lumen and axially aligned with the first access element. A filament may be electrically coupled to one or both of the first and second access element.

Abstract: A medical device that comprises an enclosure defining a cavity for containing an agent, a lumen for receiving a pressurized fluid, a channel between the cavity and the lumen, and a barrier positioned in the channel and defining a space, wherein in a first position of the barrier, the space is in fluid communication with the cavity to receive the agent from the cavity, and wherein the barrier is configured to rotate from the first position to a second position in which the space is in fluid communication with the lumen to deliver the agent from the space to the lumen.

Abstract: A medical device may comprise a flexible sheath defining a lumen extending from a proximal end of the sheath to a distal end of the sheath. The sheath may include a piston slidably received within the lumen; an agent disposed in the lumen distal to the piston; and pneumatic fluid disposed in the lumen proximal of the piston. The device may also comprise handle at a proximal end of the sheath, the handle including: a plunger received in a reservoir, wherein the reservoir is in fluid communication with the lumen. The reservoir may contain pneumatic fluid. The handle may also include a gear. An amount of rotation of the gear in a first direction may correspond to an amount that the plunger advances distally in the reservoir to displace pneumatic fluid. The displacement of the pneumatic fluid may advance the piston distally to deliver an amount of agent from the sheath.

Abstract: A device for delivering an agent may comprise a chamber for receiving agent through an agent inlet; and a body received within the chamber. The body may be movable in first and second directions along a longitudinal axis of the chamber. In a first configuration of the body, an amount of the agent may flow into the chamber via the agent inlet. In a second configuration of the body, the agent is prevented from flowing into the chamber via the agent inlet. When the body is transitioned from the first configuration to the second configuration, the amount of the agent may be moved from a first position along the longitudinal axis of the chamber to a second position along the longitudinal axis of the chamber.

Abstract: A medical device that includes an enclosure for storing an agent, an agitator positioned adjacent to or within the enclosure and configured to oscillate relative to the enclosure, and an outlet having a first end in fluid communication with the enclosure and a second end in fluid communication with a channel of a delivery tube. Oscillation of the agitator causes the agent to move toward the outlet.

Abstract: A medical device comprising a housing defining at least one enclosure for storing agent in a first form, a force applicator within the housing and adjacent the enclosure, a drive mechanism for moving the agent toward the force applicator, wherein the force applicator defines a surface for applying a force to the agent to separate the agent into particles smaller than a size of the first form, and wherein the device defines a lumen for receiving the particles from the force applicator and for receiving a pressurized fluid to propel the particles through the lumen.