Abstract: Systems, networks, methods, compositions and recombinant hosts for biosynthesizing hydrocarbons from a feedstock, such as gas, are provided.

Abstract: Systems and methods for building a monitoring fabric are described. The system receives a duplicate of a first portion of traffic information from a first network as first traffic information and communicates the first traffic information in the monitoring fabric. The first traffic information is communicated to a controller that configures the monitoring fabric. The system receives a duplicate of a second portion of the traffic information from the first network as second traffic information. The system forwards the second traffic information to at least one tool.

Abstract: An optoelectronic device may include a package having a component for sending/receiving optical signals along a first direction, and a chip of semiconductor material housed within the package. The chip may have a main surface and a portion exposed on the main surface for sending/receiving the optical signals along a second direction different from the first direction. The optoelectronic device may further include a component for deflecting the optical signals between the first direction and the second direction, the component being mounted on the main surface..

Abstract: Systems and methods for building a hyper-scale monitoring fabric are described. The system receives a duplicate of a first portion of traffic information from a production network as first traffic information and communicates the first traffic information in the hyper-scale monitoring fabric. The first traffic information is communicated to a controller computer that configures the hyper-scale monitoring fabric. The system receives a duplicate of a second portion of the traffic information from the production network as second traffic information. The system forwards the second traffic information to a tool farm.

Abstract: An optical waveguide includes a glass waveguide body and a waveguide core through which optical radiation propagates. The waveguide core includes: a body portion extending within the waveguide body, a coupling portion extending at the surface of the waveguide body, and an S-bent intermediate portion coupling the body portion and the coupling portion. An optical coupling arrangement (e.g., for coupling one or more optical fibers to a silicon photonics device) includes one such optical waveguide and a second optical waveguide including a respective waveguide body and one or more waveguide members. The second optical waveguide is coupled with the first optical waveguide with the waveguide member(s) facing the coupling portion of the first optical waveguide.

Abstract: The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.

Abstract: An optoelectronic device may include a package having a component for sending/receiving optical signals along a first direction, and a chip of semiconductor material housed within the package. The chip may have a main surface and a portion exposed on the main surface for sending/receiving the optical signals along a second direction different from the first direction. The optoelectronic device may further include a component for deflecting the optical signals between the first direction and the second direction, the component being mounted on the main surface.

Abstract: The present invention provides methods and compositions comprising at least one thermolysin-like neutral protease enzyme with improved storage stability and/or catalytic activity. In some embodiments, the thermolysin finds use in cleaning and other applications comprising detergent. In some particularly preferred embodiments, the present invention provides methods and compositions comprising thermolysin formulated and/or engineered to resist detergent-induced inactivation.

Abstract: An optical coupling includes a body having a first surface which couples with a photonics integrated circuit and a second surface including an array of lenses integral with the body. The array of lenses couples to an optical fiber connector. The array of lenses may be a linear array. The body may be made of a polymer material, which may be optically cured. The photonics integrated circuit and the optical coupling may be used, for example, in a mobile phone. The optical coupling may be made by shaping curable material on a photonics integrated circuit into a body, and curing the body of curable material. The cured body includes the first surface in contact with the photonics integrated circuit and the second surface including the array of optical lenses to couple with the optical fiber connector.

Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis.

Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.

Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.

Abstract: The present invention relates to a device for treatment of erectile dysfunction comprising a ring. The device further provides for retraction of the foreskin of the user and maintains the retraction of the foreskin throughout sexual activity. Such a device also increases the length of the sliding interface of the penis during sexual activity. Further, the device will stimulate the stretch-sensitive nerve endings of the foreskin before and during sexual activity. Further, the device will increase stimulation of the sensitive nerve endings of the glans during sexual activity. The device will also retain blood within the penis upon erection, allowing for more reliable, harder and longer erection periods. The device also creates the appearance of a larger penis.

Abstract: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N-terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ?-amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ?-amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.

Abstract: An electro-optic device may include a photonic chip having an optical grating at a surface, and an IC coupled to the photonic chip. The electro-optic device may include an optical element defining an optical path above the optical grating, and a dichroic mirror above the optical grating and aligned with the optical path.

Abstract: A modular sensor for a fluidic analysis or biological assay system, such as an analytical instrument system, and other systems involving fluid flow, includes a cap and base which include one or more sensors therein, which may be a flow sensor, a pressure sensor, a temperature sensor, a pH sensor, and so forth. The base of the modular sensor includes input and output ports for fluid passageways therethrough to provide a fluid pathway which is at least partially adjacent to or near the sensor. The modular sensor may also include an adapter having ports adapted to sealingly engage with fitting assemblies. The sensor may be partially or wholly encapsulated as part of the base of the modular sensor. The modular sensor's base and cap are adapted so that a first modular sensor can be disconnected and removed from a fluidic system and a second modular sensor can be added and connected to the system in place of the first modular sensor.

Abstract: A physiologic transmitter manages multiple communications between physiologic data acquisition devices attached to the patient and a receiver attached to an MRI or CT scanner. The transmitter's processor is able to generate waveform data and trigger data based upon the acquired physiologic data and transmit the data to a physiologic receiver attached to the host scanner. The receiver then is able to deliver a trigger signal to the host scanner for imaging the patient during a selected time frame based upon cardiac and/or respiratory cycles of the patient.

Abstract: Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.