Patents by Inventor Andrew Shaw

Andrew Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of glucose from starch using alpha-amylases from
    Patent number: 9040278
    Abstract: An ?-amylase from Bacillus subtilis (AmyE) produces significant amounts of glucose from various carbohydrate substrates, including vegetable starch, maltoheptaose, and maltotriose. Among other things, this advantageous property allows AmyE or variants thereof to be used in a saccharification reaction having a reduced or eliminated requirement for glucoamylase. The reduction or elimination of the glucoamylase requirement significantly improves the efficiency of the production of ethanol or high fructose corn syrup, for example.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: May 26, 2015
    Assignee: DANISCO US INC.
    Inventors: Luis G. Cascao-Pereira, Regina Chin, William A. Cuevas, David A. Estell, Sang-Kyu Lee, Michael J. Pepsin, Scott D. Power, Sandra W. Ramer, Carol A. Requadt, Andrew Shaw, Amr R. Toppozada, Louise Wallace
  • Variant endoglucanases and related polynucleotides
    Patent number: 9005946
    Abstract: The invention provides variants of the Clostridium thermocellum endoglucanase (CelG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: April 14, 2015
    Assignee: Codexis, Inc.
    Inventors: Jie Yang, Xiyun Zhang, Ish Kumar Dhawan, Andrew Shaw
  • Energy harvesting system
    Patent number: 9003789
    Abstract: An energy harvesting system for converting thermal energy to mechanical energy includes a heat engine that operates using a shape memory alloy active material. The shape memory alloy member may be in thermal communication with a hot region at a first temperature and a cold region at a second temperature lower than the first temperature. The shape memory alloy material may be configured to selectively change crystallographic phase between martensite to austenite and thereby one of contract and expand in response to the first and second temperatures. A thermal conduction element may be in direct contact with the SMA material, where the thermal conduction element is configured to receive thermal energy from the hot region and to transfer a portion of the received thermal energy to the SMA material through conduction.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: April 14, 2015
    Assignees: GM Global Technology Operations LLC, Dynalloy, Inc., The Regents of the University of Michigan
    Inventors: Alan L. Browne, Nancy L. Johnson, Paul W. Alexander, John Andrew Shaw, Christopher Burton Churchill, Andrew C. Keefe, Geoffrey P. McKnight, Guillermo A. Herrera, Nilesh D. Mankame, Richard J. Skurkis, Wayne Brown
  • Multiple Mutation Variants of Serine Protease
    Publication number: 20150072913
    Abstract: The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
    Type: Application
    Filed: September 11, 2014
    Publication date: March 12, 2015
    Applicant: DANISCO US INC.
    Inventors: Wolfgang Aehle, David A. Estell, Ronaldus W.J. Hommes, Brian E. Jones, Marc Kolkman, Chris Leeflang, Hiroshi Oh, Ayrookaran J. Poulose, Andrew Shaw, Wilhelmus A.H. Van der Kley, Leonardus P.M. Van Marrewijk
  • HYBRID ALPHA-AMYLASES
    Publication number: 20150017701
    Abstract: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N-terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ?-amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ?-amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
    Type: Application
    Filed: July 25, 2014
    Publication date: January 15, 2015
    Applicant: DANISCO US INC.
    Inventors: Scott D. Power, Andrew Shaw
  • OPTOELECTRONIC DEVICE HAVING IMPROVED OPTICAL COUPLING
    Publication number: 20140355995
    Abstract: An optoelectronic device may include a package having a component for sending/receiving optical signals along a first direction, and a chip of semiconductor material housed within the package. The chip may have a main surface and a portion exposed on the main surface for sending/receiving the optical signals along a second direction different from the first direction. The optoelectronic device may further include a component for deflecting the optical signals between the first direction and the second direction, the component being mounted on the main surface.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 4, 2014
    Applicant: STMICROELECTRONICS S.r.I.
    Inventors: Luca MAGGI, Antonio FINCATO, Salvatore Mario ROTOLO, Matteo Alessio TRALDI, Luigi VERGA, Mark Andrew SHAW
  • PALLET FOR BAGS
    Publication number: 20140331902
    Abstract: A pallet moulded from plastics material for supporting a flexible intermediate bulk container. It has a generally planar central panel portion, a pair of parallel inverted open channels extending across the pallet to form a respective pair of open-ended tunnels each tunnel having an upper wall and two side walls, and a pair of edge panel portions generally co-planar with the central panel. An array of raised elongate hump portions bulges upwards from the upper walls of the tunnels, each hump portion extending laterally across an upper wall. The two ends of the hump portions abut respective buttresses which extend up the side walls.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 13, 2014
    Applicant: Bulk Handling Australia Group Pty Ltd.
    Inventors: Andrew Berry, Colin Waddell, Ian Andrew Shaw
  • USE AND PRODUCTION OF CITRATE-STABLE NEUTRAL METALLOPROTEASES
    Publication number: 20140315775
    Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved stability in the presence of a metal chelator. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications comprising citrate. In some particularly preferred embodiments, the present invention provides methods and compositions comprising variant neutral metalloprotease(s) engineered to resist citrate-induced autolysis.
    Type: Application
    Filed: February 24, 2014
    Publication date: October 23, 2014
    Applicant: Danisco US Inc.
    Inventors: RONALDUS W.J. HOMMES, AMY D. LIU, ANDREW SHAW, LOUISE WALLACE
  • ELECTRONIC ASSEMBLY FOR MOUNTING ON ELECTRONIC BOARD
    Publication number: 20140312484
    Abstract: An embodiment of an electronic assembly for mounting on an electronic board includes a plurality of electric contact regions exposed on a mounting surface of the electronic board. The electronic assembly includes a chip of semiconductor material in which at least one electronic component is integrated, at least one support element including a first main surface and a second main surface opposite to the first main surface, the chip being enclosed by the at least one support element, a heat dissipation plate thermally coupled to said chip to dissipate the heat produced by it, exposed on the first main surface of the support element, a plurality of contact elements, each electrically coupled to a respective electric terminal of the electronic component integrated in the chip, exposed on the same first main surface of which is exposed to the dissipation plate.
    Type: Application
    Filed: April 22, 2014
    Publication date: October 23, 2014
    Applicant: STMicroelectronics S.r.l.
    Inventors: Pierangelo MAGNI, Giuseppe GATTAVARI, Mark Andrew SHAW
  • Multiple mutation variants of serine protease
    Patent number: 8865449
    Abstract: The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: October 21, 2014
    Assignee: Danisco US Inc.
    Inventors: Wolfgang Aehle, David A. Estell, Ronaldus W. J. Hommes, Brian E. Jones, Marc Kolkman, Chris Leeflang, Hiroshi Oh, Ayrookaran J. Poulose, Andrew Shaw, Wilhelmus A. H. Van der Kley, Leonardus P. M. Van Marrewijk
  • NOVEL VARIANT HYPOCREA JECORINA CBH1 CELLULASE
    Publication number: 20140302584
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Application
    Filed: February 25, 2014
    Publication date: October 9, 2014
    Applicant: DANISCO US INC.
    Inventors: Anthony DAY, Frits GOEDEGEBUUR, Peter GUALFETTI, Colin MITCHINSON, Paulien NEEFE, Mats SANDGREN, Andrew SHAW, Jerry STAHLBERG
  • METHOD OF PACKAGING A MEMS TRANSDUCER DEVICE AND PACKAGED MEMS TRANSDUCER DEVICE
    Publication number: 20140291781
    Abstract: A packaged MEMS transducer device comprising: a die, including: a semiconductor body having a front side and a back side, opposite to one another in a first direction, at least one cavity extending through the semiconductor body between the front side and the back side, and at least one membrane extending on the front side at least partially suspended over the cavity; and a package designed to house the die on an inner surface thereof. The transducer device moreover includes a sealing layer extending on the back side of the semiconductor body for sealing the cavity, and includes a paste layer extending between the sealing layer and the inner surface of the package for firmly coupling the die to the package.
    Type: Application
    Filed: March 25, 2014
    Publication date: October 2, 2014
    Applicant: STMicroelectronics S.r.I.
    Inventors: Mark Andrew Shaw, Fabrizio Soglio
  • Shape memory alloy heat engines and energy harvesting systems
    Patent number: 8844281
    Abstract: A heat engine includes a first rotatable pulley and a second rotatable pulley spaced from the first rotatable pulley. A shape memory alloy (SMA) element is disposed about respective portions of the pulleys at an SMA pulley ratio. The SMA element includes a first wire, a second wire, and a matrix joining the first wire and the second wire. The first wire and the second wire are in contact with the pulleys, but the matrix is not in contact with the pulleys. A timing cable is disposed about respective portions of the pulleys at a timing pulley ratio, which is different than the SMA pulley ratio. The SMA element converts a thermal energy gradient between the hot region and the cold region into mechanical energy.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: September 30, 2014
    Assignees: GM Global Technology Operations LLC, Dynalloy, Inc, The Regents of the University of Michigan
    Inventors: Alan L. Browne, Nancy L. Johnson, John Andrew Shaw, Christopher Burton Churchill, Andrew C. Keefe, Geoffrey P. McKnight, Paul W. Alexander, Guillermo A. Herrera, James Ryan Yates, Jeffrey W. Brown
  • Hybrid alpha-amylases
    Patent number: 8841107
    Abstract: Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: September 23, 2014
    Assignee: Danisco US Inc.
    Inventors: Scott D. Power, Andrew Shaw
  • Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof
    Patent number: 8809032
    Abstract: This invention relates to amylase polypeptides, and nucleic acids encoding the polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically the amylases of the current invention show an altered exospecifity.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: August 19, 2014
    Assignee: Dupont Nutrition Biosciences Aps
    Inventors: Casper Tune Berg, Kirsten Bojsen, Patrick M. F. Derkx, Carol Fioresi, Gijsbert Gerritse, Karsten Matthias Kragh, Wei Liu, Andrew Shaw, Charlotte Refdahl Thoudahl, Anja Hemmingsen Kellett-Smith
  • Method of starting and operating a shape memory alloy heat engine
    Patent number: 8800283
    Abstract: A shape memory alloy (SMA) heat engine includes a first rotatable pulley, a second rotatable pulley, and an SMA material disposed about the first and second rotatable pulleys and between a hot region and a cold region. A method of starting and operating the SMA heat engine includes detecting a thermal energy gradient between the hot region and the cold region using a controller, decoupling an electrical generator from one of the first and second rotatable pulleys, monitoring a speed of the SMA material about the first and second rotatable pulleys, and re-engaging the driven component if the monitored speed of the SMA material exceeds a threshold. The SMA material may selectively change crystallographic phase between martensite and austenite and between the hot region and the cold region to convert the thermal gradient into mechanical energy.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: August 12, 2014
    Assignees: GM Global Technology Operations LLC, Dynalloy Inc., The Regents of the University of Michigan
    Inventors: Alan L. Browne, Nancy L. Johnson, Nilesh D. Mankame, Paul W. Alexander, John Andrew Shaw, Christopher Burton Churchill, Andrew C. Keefe, Guillermo A. Herrera, Jeffrey W Brown, Richard J. Skurkis
  • Encapsulated micro-electro-mechanical device, in particular a MEMS acoustic transducer
    Patent number: 8759149
    Abstract: An encapsulated micro-electro-mechanical device, wherein a MEMS chip is encapsulated by a package formed by a first, a second, and a third substrates that are bonded together. The first substrate has a main surface bearing the MEMS chip, the second substrate is bonded to the first substrate and defines a chamber surrounding the MEMS chip, and the third substrate is bonded to the second substrate and upwardly closes the chamber. A grid or mesh structure of electrically conductive material is formed in or on the third substrate and overlies the MEMS chip; the second substrate has a conductive connection structure coating the walls of the chamber, and the first substrate incorporates an electrically conductive region, which forms, together with the conductive layer and the grid or mesh structure, a Faraday cage.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: June 24, 2014
    Assignee: STMicroelectronics S.r.l.
    Inventors: Mark Andrew Shaw, Gianmarco Antonio Camillo
  • USE AND PRODUCTION OF STORAGE-STABLE NEUTRAL METALLOPROTEASE
    Publication number: 20140134708
    Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
    Type: Application
    Filed: September 26, 2013
    Publication date: May 15, 2014
    Applicant: Danisco US Inc.
    Inventors: Andrew Shaw, Louise Wallace, David A. Estell, Ronaldus W.J. Hommes, Sang-Kyu Lee, Hiroshi Oh, Eugene S. Sadlowski
  • Variants of a Bacillus strearothermophilus alpha-amylase and uses thereof
    Patent number: 8722381
    Abstract: Described are variants of alpha (?)-amylases having altered starch hydrolysis profiles. The variants have improved thermostability and increased specific activity, resulting in reduced peak viscosity and altered final viscosity during starch liquefaction. The amylase variants are useful, e.g., in liquefaction and other starch degradation processes.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: May 13, 2014
    Assignee: Danisco US Inc.
    Inventors: Sandra W. Ramer, Michael J. Pepsin, Andrew Shaw
  • Case for infusion equipment
    Patent number: D704429
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: May 13, 2014
    Assignee: Britannia Pharmaceuticals Limited
    Inventors: Rachael Nowak, Andrew Shaw, Graham John Martin