Patents by Inventor Andrew Soliz

Andrew Soliz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Calcium controlled activation of platelets via electrical stimulation
    Patent number: 11591590
    Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: February 28, 2023
    Assignee: General Electric Company
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Steve Lambert Klopman
  • PLATELET ACTIVATION AND GROWTH FACTOR RELEASE USING ELECTRIC PULSES
    Publication number: 20230013598
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Application
    Filed: September 28, 2022
    Publication date: January 19, 2023
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Duh-Lan Lee, Allen Lawrence Garner
  • Electric pulse generation system using capacitive coupling
    Patent number: 11525768
    Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: December 13, 2022
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Allen Lawrence Garner, Andrew Soliz Torres
  • Platelet activation and growth factor release using electric pulses
    Patent number: 11464829
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 11, 2022
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Microbubble tether for diagnostic and therapeutic applications
    Patent number: 11007285
    Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: May 18, 2021
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
  • Activated platelet composition with tunable growth factor level
    Patent number: 10927345
    Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: February 23, 2021
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Vasile Bogdan Neculaes, Juan Jose Becerra, Christine Angela Morton, Andrew Soliz Torres, Antonio Caiafa
  • MICROBUBBLE TETHER FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20200345869
    Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
    Type: Application
    Filed: July 22, 2020
    Publication date: November 5, 2020
    Inventors: Matthew David BUTTS, Jason William CASTLE, Andrew Soliz TORRES, Jeannette Christine ROBERTS, Binil Itty Ipe KANDAPALLIL
  • Microbubble tether for diagnostic and therapeutic applications
    Patent number: 10751429
    Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: August 25, 2020
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
  • CALCIUM CONTROLLED ACTIVATION OF PLATELETS VIA ELECTRICAL STIMULATION
    Publication number: 20200239868
    Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 30, 2020
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Steve Lambert Klopman
  • Calcium controlled activation of platelets via electrical stimulation
    Patent number: 10633645
    Abstract: The present disclosure relates to the generation of an activated platelet product in which one or more of the presence or absence of clots, the timing of clot formation (if present), and/or the mechanical strength of clots (if present) is controlled by the presence or concentration of calcium ions during the activation process. In certain embodiments, the calcium ion concentration is controlled in the presence of pulsed electric fields or a chemical activator (e.g., thrombin) as part of the activation process.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: April 28, 2020
    Assignee: General Electric Company
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Steve Lambert Klopman
  • ELECTRIC PULSE GENERATION SYSTEM USING CAPACITIVE COUPLING
    Publication number: 20190359970
    Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
    Type: Application
    Filed: August 12, 2019
    Publication date: November 28, 2019
    Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Allen Lawrence Garner, Andrew Soliz Torres
  • Platelet Activation and Growth Factor Release Using Electric Pulses
    Publication number: 20190336578
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Application
    Filed: July 17, 2019
    Publication date: November 7, 2019
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Electric pulse generation systems using capacitive coupling
    Patent number: 10421956
    Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: September 24, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Allen Lawrence Garner, Andrew Soliz Torres
  • Platelet activation and growth factor release using electric pulses
    Patent number: 10383915
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: August 20, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Platelet activation and growth factor release using electric pulses
    Patent number: 10369200
    Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: August 6, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Vasile Bogdan Neculaes, Andrew Soliz Torres, Antonio Caiafa, Brian Dun-Lan Lee, Allen Lawrence Garner
  • Electric pulse generation systems using capacitive coupling
    Patent number: 10329551
    Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: June 25, 2019
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Allen Lawrence Garner, Andrew Soliz Torres
  • MICROBUBBLE TETHER FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
    Publication number: 20180344880
    Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
    Type: Application
    Filed: August 13, 2018
    Publication date: December 6, 2018
    Inventors: Matthew David BUTTS, Jason William CASTLE, Andrew Soliz TORRES, Jeannette Christine ROBERTS, Binil Itty Ipe KANDAPALLIL
  • ELECTRIC PULSE GENERATION SYSTEMS USING CAPACITIVE COUPLING
    Publication number: 20180237764
    Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
    Type: Application
    Filed: April 17, 2018
    Publication date: August 23, 2018
    Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Allen Lawrence Garner, Andrew Soliz Torres
  • Microbubble tether for diagnostic and therapeutic applications
    Patent number: 10052394
    Abstract: The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the albumin microbubbles relative to free, native HSA. Production of the albumin microbubble composition and use of the albumin microbubble composition in ultrasound mediated delivery of therapeutic or diagnostic agents is also discussed.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: August 21, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Matthew David Butts, Jason William Castle, Andrew Soliz Torres, Jeannette Christine Roberts, Binil Itty Ipe Kandapallil
  • Wheelchair
    Patent number: D826795
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: August 28, 2018
    Assignee: SOLSON ENTERPRISES, LLC
    Inventors: Andrew Soliz, Karen Wilson