Patents by Inventor Andrew Soliz
Andrew Soliz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140363881Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.Type: ApplicationFiled: June 6, 2013Publication date: December 11, 2014Inventors: Antonio Caiafa, Vasile Bogdan Neculaes, Andrew Soliz Torres, Allen Lawrence Garner
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Patent number: 8821838Abstract: The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: GrantFiled: August 23, 2012Date of Patent: September 2, 2014Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., Matthew David Butts, Robert Edgar Colborn, Andrew Soliz Torres
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Patent number: 8728529Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: May 20, 2014Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Patent number: 8728440Abstract: The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: GrantFiled: August 23, 2012Date of Patent: May 20, 2014Assignee: General Electric CompanyInventors: Matthew David Butts, Peter John Bonitatibus, Jr., Robert Edgar Colborn, Andrew Soliz Torres
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Publication number: 20140056819Abstract: The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: ApplicationFiled: August 23, 2012Publication date: February 27, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Peter John Bonitatibus, JR., Robert Edgar Colborn, Andrew Soliz Torres
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Publication number: 20140056821Abstract: The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X? represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.Type: ApplicationFiled: August 23, 2012Publication date: February 27, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Andrew Soliz Torres
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Patent number: 8574549Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: GrantFiled: December 29, 2008Date of Patent: November 5, 2013Assignee: General Electric CompanyInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
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Patent number: 8252317Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: GrantFiled: February 26, 2009Date of Patent: August 28, 2012Assignee: General Electric CompanyInventors: Andrew Soliz Torres, Peter John Bonitatibus, Jr.
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Patent number: 8246932Abstract: Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.Type: GrantFiled: March 28, 2008Date of Patent: August 21, 2012Assignee: General Electric CompanyInventors: Peter John Bonitatibus, Jr., Amit Mohan Kulkarni, Andrew Soliz Torres, Ying Zhou, Chiaki Treynor, Daniel Eugene Meyer
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Patent number: 8046173Abstract: The present technique provides for the analysis of a data series to identify sequences of interest within the series. The analysis may be used to iteratively update a grammar used to analyze the data series or updated versions of the data series. Furthermore, the technique provides for the calculation of a minimum description length heuristic, such as a symbol compression ratio, for each sub-sequence of the analyzed data sequence. The technique may then compare a selected heuristic value against one or more reference conditions to determine if additional iteration is to be performed. The grammar and the data sequence may be updated between iterations to include a symbol representing a string corresponding to the selected heuristic value based upon a non-termination result of the comparison. Alternatively, the string corresponding to the selected heuristic value may be identified as a sequence of interest based upon a termination result of the comparison.Type: GrantFiled: March 6, 2008Date of Patent: October 25, 2011Assignee: General Electric CompanyInventors: Scott Charles Evans, Stephen Francis Bush, Andrew Soliz Torres
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Publication number: 20110206728Abstract: A method of eliciting an immune response in an organism comprising: providing an unprocessed rolling circle amplification (RCA) product; and administering an effective amount of the unprocessed RCA product to the organism to elicit the immune response, wherein the unprocessed RCA product is prepared from a circular nucleic acid template comprising at least one promoter sequence, and at least one target sequence. A vaccine comprising unprocessed RCA product is also provided and methods for making the same.Type: ApplicationFiled: March 31, 2011Publication date: August 25, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: John Richard Nelson, Nichole Lea Wood, Brian Michael Davis, Andrew Soliz Torres
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Publication number: 20100278734Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Publication number: 20100278749Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Publication number: 20100278748Abstract: Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.Type: ApplicationFiled: April 29, 2009Publication date: November 4, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Peter John Bonitatibus, JR., Matthew David Butts, Robert Edgar Colborn, Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Patent number: 7809765Abstract: The present technique provides for the analysis of a data series to identify sequences of interest within the series. Specifically, in accordance with one embodiment of the present technique, a method is provided comprising generating a data structure that stores characteristics about a plurality of sequences present in a data series. One or more sequences are identified based upon the contents of the data structure. In accordance with other aspects of the invention, more than one heuristic is calculated for each sequence under review. The plurality of heuristics associated with each sequence are evaluated to identify a sequence of interest.Type: GrantFiled: August 24, 2007Date of Patent: October 5, 2010Assignee: General Electric CompanyInventors: Scott Charles Evans, Thomas Stephen Markham, Andrew Soliz Torres
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Publication number: 20100216243Abstract: The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.Type: ApplicationFiled: February 26, 2009Publication date: August 26, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Soliz Torres, Peter John Bonitatibus, JR.
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Publication number: 20100166666Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michacl Ernest Marino
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Publication number: 20100166665Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Publication number: 20100166664Abstract: Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Matthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Amit Mohan Kulkarni, Bruce Allan Hay, Andrew Soliz Torres, Brian Christopher Bales, Michael Ernest Marino
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Publication number: 20100008939Abstract: Methods and compositions using unprocessed (i.e., not deliberately or intentionally cleaved, circularized, or supercoiled) rolling circle amplification (RCA) product.Type: ApplicationFiled: July 9, 2008Publication date: January 14, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: John Richard Nelson, Brian Michael Davis, Andrew Soliz Torres, Nichole Lea Wood