Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Methods and systems are provided for ultrasound imaging. In one example, a method includes receiving ultrasound signals of a region of interest with a wireless hand-held probe assembly, generating a plurality of received digital signals based on the received ultrasound signals within the wireless hand-held probe assembly, generating each of a larger dataset and a smaller dataset from the plurality of received digital signals, transmitting the smaller dataset from the wireless hand-held probe assembly to a hub via a lower bandwidth wireless connection, transmitting the larger dataset from the wireless hand-held probe assembly to the hub via a higher bandwidth wireless connection, generating each of a low resolution image from the smaller dataset and a high resolution image from the larger dataset at the hub, and transmitting the low resolution image from the hub to a first display and the high resolution image from the hub to an electronic device.

Abstract: Methods and systems are provided for ultrasound imaging. In one example, a method includes receiving ultrasound signals of a region of interest with a wireless hand-held probe assembly, generating a plurality of received digital signals based on the received ultrasound signals within the wireless hand-held probe assembly, generating each of a larger dataset and a smaller dataset from the plurality of received digital signals, transmitting the smaller dataset from the wireless hand-held probe assembly to a hub via a lower bandwidth wireless connection, transmitting the larger dataset from the wireless hand-held probe assembly to the hub via a higher bandwidth wireless connection, generating each of a low resolution image from the smaller dataset and a high resolution image from the larger dataset at the hub, and transmitting the low resolution image from the hub to a first display and the high resolution image from the hub to an electronic device.

Abstract: Provided in this disclosure are anti-CD38 binding domains, a composition comprising the anti-CD38 binding domains, nucleic acids encoding the anti-CD38 binding domains, and a method of using the anti-CD38 binding domains or the composition for treating multiple myeloma.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Provided in this disclosure are anti-CD38 binding domains, a composition comprising the anti-CD38 binding domains, nucleic acids encoding the anti-CD38 binding domains, and a method of using the anti-CD38 binding domains or the composition for treating multiple myeloma.

Abstract: Examples are disclosed that relate to a display device. One example provides a display device comprising a projector and a pre-expander optic configured to replicate an exit pupil of the projector in at least a first direction, the pre-expander optic comprising a plurality of spectrally-selective pupil-replicating elements to form at least two exit pupils at different spatial locations, each exit pupil being for a different spectral band. The display device further comprises a waveguide comprising at least two incoupling pupils, each incoupling pupil configured to receive light from a corresponding exit pupil of the pre-expander optic, and the waveguide configured to replicate each corresponding exit pupil in at least a second direction and output the light received toward an eyebox.

Abstract: An eye-tracking system is provided. The system includes an at least partially transparent visible light waveguide having a visible light display region configured to emit visible light to impinge upon an eye of a user. A light source is configured to emit at least infrared (IR) light that travels along an IR light path to impinge on the eye. A microelectromechanical system (MEMS) scanning mirror positioned in the IR light path is configured to direct the IR light along the IR light path. A relay positioned in the IR light path downstream of the MEMS scanning mirror includes at least one mirror configured to reflect the IR light along the IR light path. At least one sensor is configured to receive the IR light after being reflected by the eye.

Abstract: Examples are disclosed that relate to expanding an exit pupil of a display device via a curved waveguide. One example provides a curved waveguide, including an input coupler configured to couple light into the curved waveguide, a first reflective surface, a second reflective surface opposing the first reflective surface, and an output coupler configured to couple the light out of the curved waveguide. The curved waveguide also has a curvature in a direction transverse to an optical path between the input coupler and the output coupler, the curvature having a radius that varies along a direction extending between the input coupler and the output coupler.

Abstract: The technology provides decoupling an aspheric optical element from a birdbath optical element in a near-eye display (NED) device. One or more aspheric lens are used with a spherical birdbath reflective mirror in a projection light engine of a NED device. A projection light engine provides image light (or other information), by way of the spherical birdbath reflective mirror and at least one aspheric lens, to a near-eye display of the NED device. The spherical birdbath reflective mirror collimates and reflects the image light to an exit pupil external to the projection light engine. Decoupling the aspheric optical element from the spherical birdbath reflective mirror may enable high modulation transfer function (MTF) and improved manufacturability of the projection light engine. The NED device having aspheric optical elements decoupled from a birdbath optical element may be positioned by a support structure in a head-mounted display (HMD) or head-up display (HUD).

Abstract: An eye-tracking system includes an at least partially transparent visible light waveguide having a visible light display region configured to emit visible light to an eye of a user. A light source is configured to emit at least infrared (IR) light that travels along an IR light path to the eye of the user. A microelectromechanical system (MEMS) projector positioned in the IR light path directs the IR light. At least one diffractive input coupler on an input end of the IR light path downstream of the MEMS projector diffracts at least a portion of the IR light. At least one diffractive output coupler positioned in the IR light path downstream of the diffractive input coupler receives the IR light and directs the IR light toward the eye. At least one sensor is configured to receive the IR light after being reflected by the eye.

Abstract: Provided in this disclosure are anti-CD38 binding domains, a composition comprising the anti-CD38 binding domains, nucleic acids encoding the anti-CD38 binding domains, and a method of using the anti-CD38 binding domains or the composition for treating multiple myeloma.

Abstract: Examples are disclosed that relate to expanding an exit pupil of a display device via a curved waveguide. One example provides a curved waveguide, including an input coupler configured to couple light into the curved waveguide, a first reflective surface, a second reflective surface opposing the first reflective surface, and an output coupler configured to couple the light out of the curved waveguide. The curved waveguide also has a curvature in a direction transverse to an optical path between the input coupler and the output coupler, the curvature having a radius that varies along a direction extending between the input coupler and the output coupler.

Abstract: A light engine comprises a liquid crystal on silicon (LCOS) panel that is operated in combination with illumination and imaging optics to project high-resolution virtual images into a waveguide-based exit pupil expander (EPE) that provides an expanded exit pupil in a near-eye display system. In an illustrative example, the illumination optics comprise a laser that produces illumination light that is reflected by a MEMS (micro-electromechanical system) scanner using raster scanning to post-scan optics including a microlens array (MLA) and one or more collimating or magnifying lenses before impinging on the LCOS panel. The LCOS panel operates in reflection in combination with imaging optics, including one or more of beam-steering mirror and beam splitter, to couple virtual image light from the LCOS panel into the EPE.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: An input-coupler of an optical waveguide includes one or more Bragg polarization gratings for coupling light corresponding to the image in two different directions into the optical waveguide. The input-coupler splits the FOV of the image coupled into the optical waveguide into first and second portions by diffracting a portion of the light corresponding to the image in a first direction toward a first intermediate component, and diffracting a portion of the light corresponding to the image in a second direction toward a second intermediate component. An output-coupler of the waveguide combines the light corresponding to the first and second portions of the FOV, and couples the light corresponding to the combined first and second portions of the FOV out of the optical waveguide so that the light corresponding to the image and the combined first and second portions of the FOV is output from the optical waveguide.

Abstract: A display device system includes a display engine and optical waveguide. The display engine includes an image former, that produces light corresponding to an image, and one or more lens groups that collimate the light corresponding to the image and outputs the light from the display engine. Each lens group includes one or more lenses that share a mechanical axis. The light corresponding to the image produced by the image former has an optical axis ray coincident with a principal ray of the light that originates at a center of the image produced by the image former. At least one lens group has its mechanical axis tilted relative to the optical axis ray of the light corresponding to the image produced by the image former, to prevent a ghost image from being formed by light corresponding to the image that is reflected-back from the waveguide toward the display engine.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.