Patents by Inventor Andrew Wolfe

Andrew Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12239546
    Abstract: An intervertebral scaffolding system is provided having an expandable frame operable for a reversible collapse from an expanded state into a collapsed state, the expandable frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the expandable frame and both the stabilizer and the one or more tensioners are configured for retaining the expandable frame from a lateral movement that exceeds the expanded state, and the stabilizer can include a locking element that engages with the expansion member to lock the expansion member to the stabilizer when the expansion member is fully inserted into the frame. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Grant
    Filed: August 7, 2023
    Date of Patent: March 4, 2025
    Assignee: INTEGRITY IMPLANTS INC.
    Inventors: John To, John J. Flynn, John Souza, Andrew Wolf
  • Publication number: 20250017569
    Abstract: Devices and methods are provided herein for locating and monitoring subcutaneous target sites. A device as described herein may comprise a base layer configured to attach to a portion of a subject's body in proximity to the target site; and a plurality of transducer elements on the base layer, wherein the plurality of transducer elements are configured to (1) transmit a set of signals that penetrate beneath the skin of the subject and (2) receive a set of reflected signals associated with underlying anatomical structures, the underlying anatomical structures comprising the target site and bodily tissue surrounding the target site, wherein the set of reflected signals is used to identify a location of the target site while the device is placed in situ on the subject's body, without having to physically move the device over the portion of the subject's body to search for the target site.
    Type: Application
    Filed: June 11, 2024
    Publication date: January 16, 2025
    Inventors: Dimitri Alain Augustin, Racquel Tiffany Redwood, Zachary Andrew Wolf, Bryan Irby Hartley
  • Patent number: 12098381
    Abstract: The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: September 24, 2024
    Assignee: University of Massachusetts
    Inventors: Thoru Pederson, Scot Andrew Wolfe, Hanhui Ma, Metewo Selase Kosi Enuameh, Nicola Anne Kearns, Ryan Michael Jude Genga, Rene Maehr, Shaojie Zhang, Ardalan Naseri, Manuel Garber
  • Publication number: 20240271112
    Abstract: The present invention utilizes a Cas9 nickase which nicks a flanking target sequence to a duplicated gene sequence (e.g., a retroviral LTR). This nicking causes a genomic collapse of the sequence between the nick and the LTR, thereby deleting the sequence from the genome. Because the nickase does not introduce mutations at the target site, this method can be repeated maximize the efficiency (e.g., 100% of retroviral genome excision. For example, this method is useful to delete all PERVs within a pig genome intended for human transplantation. Further, such PERV-free cells can then be used to clone PERV-free pigs. Furthermore, this method is useful to remove amplified gene repeats in cancer cells.
    Type: Application
    Filed: May 31, 2022
    Publication date: August 15, 2024
    Inventors: Scot Andrew Wolfe, Ester Mintzer, Jeremy Luban, Jason Shohet
  • Publication number: 20240074871
    Abstract: An intervertebral scaffolding system is provided having an expandable frame operable for a reversible collapse from an expanded state into a collapsed state, the expandable frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the expandable frame and both the stabilizer and the one or more tensioners are configured for retaining the expandable frame from a lateral movement that exceeds the expanded state, and the stabilizer can include a locking element that engages with the expansion member to lock the expansion member to the stabilizer when the expansion member is fully inserted into the frame. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Application
    Filed: August 7, 2023
    Publication date: March 7, 2024
    Inventors: John TO, John J. FLYNN, John SOUZA, Andrew WOLF
  • Patent number: 11898114
    Abstract: The present disclosure relates to a composition that includes a compound having the structure R1O—(CH2O)n—R2 and a cetane number between about 65 and about 100, where n is between 1 and 10, inclusively, R1 includes a first alkyl group, and R2 includes a second alkyl group.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: February 13, 2024
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: Daniel Ruddy, Thomas Dwight Foust, Trenton John Wilke, Anh The To, Andrew Wolf Bartling, Martha Arellano-Trevino
  • Patent number: 11763804
    Abstract: A method of leveraging a dialogue history of a conversational computing interface to execute an updated dialogue plan. The method comprises maintaining an annotated dialogue history of the conversational computing interface. The annotated dialogue history includes a plurality of traced steps defining a data-flow including input data used to execute a context-dependent operation and output data recorded from a previous execution of the context-dependent operation. The method further comprises recognizing an updated dialogue plan including a prefix of executable steps and an updated executable step following the prefix. The method further comprises automatically computer-recognizing that the prefix of executable steps of the updated dialogue plan matches a corresponding prefix of traced steps in the annotated dialogue history. The method further comprises re-using the data-flow from the prefix of traced steps in the annotated dialogue history to automatically determine input data of the updated executable step.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: September 19, 2023
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: David Leo Wright Hall, Pengyu Chen, Jason Andrew Wolfe, Jayant Sivarama Krishnamurthy
  • Patent number: 11749274
    Abstract: A method includes receiving an utterance at a computerized automated assistant system, and detecting, via a date/time constraint module of the computerized automated assistant system, one or more constraints in the utterance associated with a date or time. The utterance is associated with a domain. The method further comprises generating, via the date/time constraint module, a periodic set for each of the one or more constraints associated with the date or time, and combining, via the date/time constraint module, the one or more periodic sets. The method further comprises processing, via a dialogue manager module of the computerized automated assistant system, the combined periodic sets to determine an action, and executing the action at the computerized automated assistant system.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: September 5, 2023
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Jordan Rian Cohen, David Leo Wright Hall, Jason Andrew Wolfe, Daniel Lawrence Roth, Daniel Klein
  • Patent number: 11717415
    Abstract: An intervertebral scaffolding system is provided having a laterovertically-expanding frame operable for a reversible collapse from an expanded state into a collapsed state, the laterovertically-expanding frame having a stabilizer, one or more tensioners, or a combination of the stabilizer with one or more tensioners. The stabilizer slidably engages with the distal region of the laterovertically-expanding frame and both the stabilizer and the one or more tensioners are configured for retaining the laterovertically-expanding frame from a lateral movement that exceeds the expanded state, and the stabilizer can include a locking element that engages with the expansion member to lock the expansion member to the stabilizer when the expansion member is fully inserted into the frame. The expanded state, for example, can be configured to have an open graft distribution window that at least substantially closes upon the reversible collapse.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: August 8, 2023
    Assignee: Integrity Implants Inc.
    Inventors: John To, John J. Flynn, John Souza, Andrew Wolf
  • Patent number: 11672715
    Abstract: A therapeutic support device includes a bladder having one or more independently inflatable compartments, each including a plurality of inflatable cells. When inflated, each inflatable cell forms a contact node that may support a user or another object disposed thereon. The inflatable compartments can be alternately inflated and deflated such that contact pressure can be applied to and relieved from corresponding portions of the user's body in an alternating manner.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: June 13, 2023
    Assignee: DABIR SURFACES, INC.
    Inventors: David A. Dzioba, Kenneth Andrew Wolf, Timothy Wyrick
  • Patent number: 11648361
    Abstract: An apparatus for providing a pressurized atmosphere to a patient including one or more flat sheets of plastic arranged in an envelope and sealed around the periphery to form an airtight container. The helmet has an airtight collar that is configured to accommodate a patient's neck and form an airtight seal. An intake port is integrated into the helmet and receives pressurized air. An exhaust port is integrated into the helmet near the patient's mouth when the helmet is in use. Additional ports can be added to the helmet to provide more functionality such as feeding or supplemental oxygen.
    Type: Grant
    Filed: March 27, 2021
    Date of Patent: May 16, 2023
    Inventor: Andrew Wolf
  • Publication number: 20220411454
    Abstract: Described herein are devices and methods for the efficient and economic generation of lignin monomers from biomass. The provided devices and methods utilize reductive catalytic fractionation with an organic solvent to extract high-quality lignin from biomass and cleave specific lignin bonds to generate valuable lignin monomers with a relatively narrow product slate. Advantageously, the devices and methods described herein utilize solvent recycling, multiple solvolysis chambers with multiple biomass beds and/or physical agitation (e.g., use of a screw extruder) to reduce the amount of solvent required and increase economic efficiency and monomer yield.
    Type: Application
    Filed: June 16, 2022
    Publication date: December 29, 2022
    Inventors: Jacob S. KRUGER, Gregg Tyler BECKHAM, David Gregory BRANDNER, Andrew Wolf BARTLING, Yuriy ROMÁN, Jun Hee JANG, Nicholas Earl Thornburg, Gregory George Facas
  • Publication number: 20220195322
    Abstract: The present disclosure relates to a composition that includes a compound having the structure R1O—(CH2O)n—R2 and a cetane number between about 65 and about 100, where n is between 1 and 10, inclusively, R1 includes a first alkyl group, and R2 includes a second alkyl group.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 23, 2022
    Inventors: Daniel RUDDY, Thomas Dwight FOUST, Trenton John WILKE, Anh The TO, Andrew Wolf BARTLING, Martha ARELLANO-TREVINO
  • Patent number: 11363591
    Abstract: A matchmaking service can match a satellite owner/operator with antennas that are available and capable of servicing a communication request from the satellite owner/operator (e.g., to exchange data with the satellite owner/operator's satellite). The communication request may be received at a ground station service, and information included therein may be compared to capabilities of antennas registered with the ground station service to determine antennas that are compatible with the request. The ground station service may reserve a time slot for a selected compatible antenna to service the request and control the selected compatible antenna (e.g., to track and communicate with the satellite) during the time slot. In some embodiments, the matchmaking of satellite owners/operators to antennas uses models to determine communication parameters for a communication request and to determine capabilities of antennas registered with the ground station.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: June 14, 2022
    Assignee: Amazon Technologies, Inc.
    Inventors: Prabu Ramachandran, Nathan Burns, Michelle Lynn Dobbs, Andrew Wolfe, Kevin Cheek, John Garvey, Ben Linville, Ismael Gonzales
  • Patent number: 11195523
    Abstract: A method comprising recognizing a user utterance including an ambiguity. The method further comprises using a previously-trained code-generation machine to produce, from the user utterance, a data-flow program including a search-history function. The search-history function is configured to select a highest-confidence disambiguating concept from one or more candidate concepts stored in a context-specific dialogue history.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: December 7, 2021
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: David Leo Wright Hall, David Ernesto Heekin Burkett, Jesse Daniel Eskes Rusak, Jayant Sivarama Krishnamurthy, Jason Andrew Wolfe, Adam David Pauls, Alan Xinyu Guo, Jacob Daniel Andreas, Daniel Louis Klein
  • Publication number: 20210299385
    Abstract: An apparatus for providing a pressurized atmosphere to a patient including one or more flat sheets of plastic arranged in an envelope and sealed around the periphery to form an airtight container. The helmet has an airtight collar that is configured to accommodate a patient's neck and form an airtight seal. An intake port is integrated into the helmet and receives pressurized air. An exhaust port is integrated into the helmet near the patient's mouth when the helmet is in use. Additional ports can be added to the helmet to provide more functionality such as feeding or supplemental oxygen.
    Type: Application
    Filed: March 27, 2021
    Publication date: September 30, 2021
    Inventor: Andrew Wolf
  • Publication number: 20210306990
    Abstract: A matchmaking service can match a satellite owner/operator with antennas that are available and capable of servicing a communication request from the satellite owner/operator (e.g., to exchange data with the satellite owner/operator's satellite). The communication request may be received at a ground station service, and information included therein may be compared to capabilities of antennas registered with the ground station service to determine antennas that are compatible with the request. The ground station service may reserve a time slot for a selected compatible antenna to service the request and control the selected compatible antenna (e.g., to track and communicate with the satellite) during the time slot. In some embodiments, the matchmaking of satellite owners/operators to antennas uses models to determine communication parameters for a communication request and to determine capabilities of antennas registered with the ground station.
    Type: Application
    Filed: December 22, 2020
    Publication date: September 30, 2021
    Applicant: Amazon Technologies, Inc.
    Inventors: Prabu Ramachandran, Nathan Burns, Michelle Lynn Dobbs, Andrew Wolfe, Kevin Cheek, John Garvey, Ben Linville, Ismael Gonzales
  • Patent number: 11106536
    Abstract: A method, comprising recognizing a user utterance for processing. The method further comprises using a previously-trained code-generation machine to generate, from the user utterance, a data-flow program configured to produce a return value upon successful execution. The method further comprises beginning execution of the data-flow program. Responsive to reaching an error condition resulting from execution of the data-flow program, the method further comprises, prior to the data-flow program producing the return value, suspending execution of the data flow program. The method further comprises using the previously-trained code-generation machine to generate an error-handling data-flow program, wherein the error-handling data-flow program is configured to produce the return value; beginning execution of the error-handling data-flow program to produce the return value; and outputting the return value.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 31, 2021
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: David Leo Wright Hall, David Ernesto Heekin Burkett, Jesse Daniel Eskes Rusak, Alexander J. Kolmykov-Zotov, Jason Andrew Wolfe, Jacob Daniel Andreas, Adam David Pauls, John Philip Bufe, III, Jayant Sivarama Krishnamurthy, Daniel Louis Klein
  • Patent number: 11028380
    Abstract: The present invention provides a Cas9 platform to facilitate single-site nuclease gene editing precision within a human genome. For example, a Cas9 nuclease/DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9/sgRNA complex to a specific target site within the genome for subsequent sgRNA-dependent cleavage of an adjacent target sequence. Alternatively, attenuating Cas9 binding using mutations to the a protospacer adjacent motif (PAM) recognition domain makes Cas9 target site recognition dependent on the associated DTU, all while retaining Cas9's sgRNA-mediated DNA cleavage fidelity. Cas9-DTU fusion proteins have improved target site binding precision, greater nuclease activity, and a broader sequence targeting range than standard Cas9 systems. Existing Cas9 or sgRNA variants (e.g., truncated sgRNAs (tru-gRNAs), nickases and FokI fusions) are compatible with these improvements to further reduce off-target cleavage.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: June 8, 2021
    Assignee: University of Massachusetts
    Inventors: Scot Andrew Wolfe, Mehmet Fatih Bolukbasi, Ankit Gupta, Erik J Sontheimer, Nadia Amrani
  • Patent number: D984211
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 25, 2023
    Assignee: Fireside Industries, Inc.
    Inventor: Mark Andrew Wolf