Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.

Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.

Abstract: Provided herein are compositions and methods for selective expression of a transgene. Compositions and methods for selective expression of a transgene comprise one or more human regulatory elements, which, when operably linked to a transgene, can facilitate selective expression of a transgene (e.g., cell-type selective expression) in a target cell as compared to at least one or more non-target cells.

Abstract: Gaze tracking data representing a viewer's gaze with respect to one or more images presented to the viewer is used to generate foveated image data representing one or more foveated images characterized by a higher level of detail within one or more regions of interest and a lower level of detail outside the regions of interest. The image data for portions outside the one or more regions of interest is selectively filtered to reduce visual artifacts due to contrast resulting from the lower level of detail before compositing foveated images for presentation.

Abstract: A method for implementing a graphics pipeline. The method includes generating a system of particles creating an effect in a virtual scene, the system of particles comprising a plurality of particle geometries. The method includes determining a subsystem of particles from the system of particles, the subsystem of particles comprising a subset of particle geometries taken from the plurality of particle geometries. The method includes determining a foveal region when rendering an image of the virtual scene, wherein the foveal region corresponds to where an attention of a user is directed. The method includes determining that at least one portion of the effect is located in the peripheral region for the image. The method includes rendering the subsystem of particles to generate the effect.

Abstract: Methods and systems are provided for enabling foveal adaption of temporal anti-aliasing within a foveated rendering presentation. A method for rendering a multi-resolution scene with anti-aliasing within a head mounted display (HMD) is provided. The method includes an operation for rendering a scene that includes a series of video frames. The method also includes operations for applying anti-aliasing to a first region of the scene using a first jitter offset and applying anti-aliasing to a second region of the scene using a second jitter offset. Further, the method provides for generating a foveated scene that includes the first region and the second region and for sending the foveated scene to be displayed on a display associated with the HMD, wherein the first region is associated with a higher resolution than the second scene and the first jitter offset is smaller than the second jitter offset, according to certain embodiments.

Abstract: A method for implementing a graphics pipeline. The method includes determining a plurality of light sources affecting a virtual scene. Geometries of objects of an image of the scene is projected onto a plurality of pixels of a display from a first point-of-view. The pixels are partitioned into a plurality of tiles. A foveal region of highest resolution is defined for the image as displayed, wherein a first subset of pixels is assigned to the foveal region, and wherein a second subset of pixels is assigned to a peripheral region that is outside of the foveal region. A first set of light sources is determined from the plurality of light sources that affect one or more objects displayed in a first tile that is in the peripheral region. At least two light sources from the first set is clustered into a first aggregated light source affecting the first tile when rendering the image in pixels of the first tile.

Abstract: A method for implementing a graphics pipeline. The method includes generating a plurality of bones for an object defining positioning relationships between the bones. The method includes determining a subsystem of bones from the plurality of bones for the object. The method includes determining a foveal region when rendering an image of the virtual scene including the object, wherein the foveal region corresponds to where an attention of a user is directed. The method includes determining that at least one portion of the object is located in a peripheral region for the image. The method includes animating the object by applying a transformation to the subsystem of bones.

Abstract: Methods and systems are provided for using temporal supersampling to increase a displayed resolution associated with peripheral region of a foveated rendering view. A method for enabling reconstitution of higher resolution pixels from a low resolution sampling region for fragment data is provided. The method includes an operation for receiving a fragment from a rasterizer of a GPU and for applying temporal supersampling to the fragment with the low resolution sampling region over a plurality of prior frames to obtain a plurality of color values. The method further includes an operation for reconstituting a plurality of high resolution pixels in a buffer that is based on the plurality of color values obtained via the temporal supersampling. Moreover, the method includes an operation for sending the plurality of high resolution pixels for display.

Abstract: A method for implementing a graphics pipeline. The method includes building a first shadow map of high resolution, and building a second shadow map based on the first shadow map of lower resolution. The method includes determining a light source affecting a virtual scene, and projecting geometries of objects of an image of the virtual scene onto a plurality of pixels of a display from a first point-of-view. The method includes determining a foveal region when rendering the image, wherein the foveal region corresponds to where an attention of a user is directed. The method includes determining a first set of geometries is drawn to a first pixel, determining the first set of geometries is in shadow based on the light source, and determining the first set of geometries is outside of the foveal region. The method includes rendering the first set of geometries using the second shadow map.

Abstract: A push rack pipe pusher having a base. A first frame coupled to the base. A second frame coupled to the base. A first pressurized cylinder coupled to the base. A second pressurized cylinder coupled to the base. A third pressurized cylinder coupled to the base. A fourth pressurized cylinder coupled to the base. A lower track conveyer system coupled to the base and positioned between the first frame and the second frame. An upper track conveyer system coupled to the pressurized cylinders and positioned between the first frame and the second frame. A control unit coupled to the upper track conveyer system, the lower track conveyer system, and the pressurized cylinders.

Abstract: The disclosure provides a procatalyst for the polymerization of ethylene and optionally one or more alpha-olefins having the structure shown in formula (I) below: wherein at least two of Y1-Y3 and at least two of Y4-Y6 are fluorine atoms and when only two of Y1-Y3 and only two of Y4-Y6 are fluorine atoms, the non-fluorine Y1-Y6 are selected from the group consisting of H atom, alkyl groups, aryl groups, heteroaryl groups, and alkoxy groups. Also provided is a polymerization process using the procatalyst.

Abstract: Provided herein are methods and compositions for treating metabolic diseases and conditions associated with metabolic diseases.

Abstract: Provided is a method for administering to a subject, via an implantable delivery device, a continuous subcutaneous dose of glucagon-like peptide-1 (GLP-1) analog, where the subject is orally co-administered a drug after implantation of the implantable delivery device and during continuous subcutaneous dosing of the GLP-1 analog.

Abstract: An intelligent controls system for remotely monitoring and controlling a chemical process is disclosed. The system comprises a piece of remote field equipment for performing the chemical process, a user device, a server, and program codes to perform the steps of establishing an equipment-server and a client-server connection, receiving a set of chemical process input parameters and a set of desired chemical process output parameters, controlling a set of chemical process control parameters to achieve the desired chemical process output parameters, and providing an interface to allow an operator to manually control and/or manually override the set of chemical process control parameters. The controls system allows any piece of remote field equipment for performing complex chemical processing to be monitored, controlled, and operated remotely. A large array of distributed field equipment situated around the world can all be controlled primarily through a single interface provided in a central control center.

Abstract: Carbon fiber composites containing lignin carbon fibers are described. The lignin carbon fibers can be derived from organosolv lignin obtained from single source lignocellulosic feedstocks or combinations of such feedstocks or lignin obtained via other pulping or extraction methods. Also described are methods of preparing the carbon fiber composites.

Abstract: This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

Abstract: The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing (NGS). Further, the methods disclosed herein enable multiplex targeting of genomic DNA.

Abstract: An intelligent controls system for remotely monitoring and controlling a chemical process is disclosed. The system comprises a piece of remote field equipment for performing the chemical process, a user device, a server, and program codes to perform the steps of establishing an equipment-server and a client-server connection, receiving a set of chemical process input parameters and a set of desired chemical process output parameters, controlling a set of chemical process control parameters to achieve the desired chemical process output parameters, and providing an interface to allow an operator to manually control and/or manually override the set of chemical process control parameters. The controls system allows any piece of remote field equipment for performing complex chemical processing to be monitored, controlled, and operated remotely. A large array of distributed field equipment situated around the world can all be controlled primarily through a single interface provided in a central control center.