Patents by Inventor Angela M. Christiano

Angela M. Christiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190262250
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 12, 2019
    Publication date: August 29, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20190142722
    Abstract: The presently disclosed subject matter relates, in certain embodiments, to compositions and methods for the inhibition of the Janus activated kinase-signal transducer and activator of transcription (JAK-STAT) pathway, and particularly inhibition of oncostatin (e.g. oncostatin M (OSM)), colony stimulating factor 1 receptor (CSF1R), interleukin-34 (IL-34), and/or trichophages, in order to induce or promote hair growth. In certain embodiments, the presently disclosed subject matter relates to topical treatments with small molecule inhibitors of the JAK-STAT pathway, and particularly small molecule inhibitors of oncostatin, CSF1R, IL-34, and/or trichophages, to induce or promote hair growth. Some embodiments are directed to treating hair loss disorders using inhibitors of oncostatin, CSF1R, IL-34 and/or trichophages. Embodiments also describe kits including inhibitors of oncostatin, CSF1R, IL-34 and/or trichophages.
    Type: Application
    Filed: November 9, 2018
    Publication date: May 16, 2019
    Inventor: Angela M. Christiano
  • Patent number: 10265258
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: April 23, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9895301
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 20, 2018
    Assignee: The Trustees of Columbia University in The City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20180021235
    Abstract: The invention provides for methods for treating a hiar loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 4, 2017
    Publication date: January 25, 2018
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9763866
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 19, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9737469
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: August 22, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9730877
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 15, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9550976
    Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: January 24, 2017
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, DURHAM UNIVERSITY
    Inventors: Angela M. Christiano, Colin A. B. Jahoda
  • Publication number: 20160256461
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160256374
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160068807
    Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 10, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Colin A.B. Jahoda
  • Publication number: 20160058765
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 3, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160058764
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 3, 2016
    Applicant: The Trustees of Columbia University in The City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160009797
    Abstract: The presently disclosed subject matter provides methods for treating a hair loss disorder in a subject by administering a FGF5 inhibitor. The presently disclosed subject matter further provides methods for treating a hair growth disorder in a subject by administering a FGF5 activator.
    Type: Application
    Filed: January 30, 2015
    Publication date: January 14, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Angela M. Christiano
  • Patent number: 9198911
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 1, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9109204
    Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: August 18, 2015
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, DURHAM UNIVERSITY
    Inventors: Angela M. Christiano, Colin A. B. Jahoda
  • Publication number: 20140134188
    Abstract: The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention farther provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.
    Type: Application
    Filed: September 30, 2013
    Publication date: May 15, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Angela M. Christiano
  • Publication number: 20140065153
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a JAK/STAT inhibitor.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20130078244
    Abstract: The invention provides for methods for controlling hair growth by administering a HLDGC modulating compound to a subject. The invention further provides for a method for screening compounds that bind to and modulate polypeptides encoded by HLDGC genes. The invention also provides methods of detecting the presence of or a predisposition to a hair-loss disorder in a human subject as well as methods of treating such disorders.
    Type: Application
    Filed: July 2, 2012
    Publication date: March 28, 2013
    Inventors: ANGELA M. CHRISTIANO, Raphael Clynes