Patents by Inventor Angela M. Christiano

Angela M. Christiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR REGULATING HAIR GROWTH DISORDERS
    Publication number: 20160009797
    Abstract: The presently disclosed subject matter provides methods for treating a hair loss disorder in a subject by administering a FGF5 inhibitor. The presently disclosed subject matter further provides methods for treating a hair growth disorder in a subject by administering a FGF5 activator.
    Type: Application
    Filed: January 30, 2015
    Publication date: January 14, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Angela M. Christiano
  • Methods for treating hair loss disorders
    Patent number: 9198911
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 1, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Methods for compact aggregation of dermal cells
    Patent number: 9109204
    Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: August 18, 2015
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, DURHAM UNIVERSITY
    Inventors: Angela M. Christiano, Colin A. B. Jahoda
  • Methods for P2RY5 Mediated Regulation of Hair Growth and Mutants Thereof
    Publication number: 20140134188
    Abstract: The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention farther provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.
    Type: Application
    Filed: September 30, 2013
    Publication date: May 15, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Angela M. Christiano
  • Methods for Treating Hair Loss Disorders
    Publication number: 20140065153
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a JAK/STAT inhibitor.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • METHODS FOR DETECTING AND REGULATING ALOPECIA AREATA AND GENE COHORTS THEREOF
    Publication number: 20130078244
    Abstract: The invention provides for methods for controlling hair growth by administering a HLDGC modulating compound to a subject. The invention further provides for a method for screening compounds that bind to and modulate polypeptides encoded by HLDGC genes. The invention also provides methods of detecting the presence of or a predisposition to a hair-loss disorder in a human subject as well as methods of treating such disorders.
    Type: Application
    Filed: July 2, 2012
    Publication date: March 28, 2013
    Inventors: ANGELA M. CHRISTIANO, Raphael Clynes
  • Inhibition of hairless protein mRNA
    Patent number: 8329667
    Abstract: Methods for inhibition of hairless protein mRNA using RNA interference is described, in particular methods for hair removal. Also described are nucleic acid constructs for RNAi-mediated inhibition of hairless protein mRNA and compositions including such constructs.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: December 11, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Angela M. Christiano
  • METHODS FOR APCDD1 MEDIATED REGULATION OF HAIR GROWTH AND PIGMENTATION AND MUTANTS THEREOF
    Publication number: 20120003244
    Abstract: The invention provides for methods for controlling hair growth by administering an APCDD1 modulating compound to a subject. The invention further provides for a method for screening compounds that bind to and modulate APCDD1.
    Type: Application
    Filed: May 2, 2011
    Publication date: January 5, 2012
    Inventor: Angela M. Christiano
  • Nucleic acids for inhibiting hairless protein expression and methods of use thereof
    Patent number: 8008471
    Abstract: The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: August 30, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Angela M. Christiano
  • METHODS FOR P2RY5 MEDIATED REGULATION OF HAIR GROWTH AND MUTANTS THEREOF
    Publication number: 20110189199
    Abstract: The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention further provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.
    Type: Application
    Filed: July 7, 2010
    Publication date: August 4, 2011
    Inventor: Angela M. Christiano
  • METHODS FOR COMPACT AGGREGATION OF DERMAL CELLS
    Publication number: 20100303767
    Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
    Type: Application
    Filed: February 28, 2007
    Publication date: December 2, 2010
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Colin A.B. Jahoda
  • NUCLEIC ACIDS FOR INHIBITING HAIRLESS PROTEIN EXPRESSION AND METHODS OF USE THEREOF
    Publication number: 20100221318
    Abstract: The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.
    Type: Application
    Filed: March 1, 2010
    Publication date: September 2, 2010
    Inventor: Angela M. Christiano
  • CADHERIN-11-MEDIATED MODULATION OF HAIR GROWTH
    Publication number: 20100137416
    Abstract: The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of CAD1 1 mRNA and/or protein in hair follicle cells of a subject. The present invention further provides for methods of promoting hair growth, comprising increasing the level of CADI 1 mKNA and/or protein in hair follicle cells of a subject. The invention also provides for transgenic animals with aberrancies in CADI 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase CADI 1 expression.
    Type: Application
    Filed: February 3, 2010
    Publication date: June 3, 2010
    Inventor: ANGELA M. CHRISTIANO
  • R-SPONDIN COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20090208484
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a regulator of Wnt signaling, R-spondin 4. The invention further provides for methods for diagnosing a keratin-related abnormality, such as anonychia congenital, in a subject. The invention also provides for isolated RSPO4 mutant molecules.
    Type: Application
    Filed: February 12, 2009
    Publication date: August 20, 2009
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Angela M. Christiano
  • Nucleic Acids For Inhibiting Hairless Protein Expression and Methods of Use Thereof
    Publication number: 20090004169
    Abstract: The present invention provides DNAzymes and ribozymes that specifically cleave Hairless protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The present invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.
    Type: Application
    Filed: June 16, 2008
    Publication date: January 1, 2009
    Inventor: Angela M. Christiano
  • CADHERIN-11-MEDIATED MODULATION OF HAIR GROWTH
    Publication number: 20080287359
    Abstract: The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of CAD1 1 mRNA and/or protein in hair follicle cells of a subject. The present invention further provides for methods of promoting hair growth, comprising increasing the level of CADI 1 mKNA and/or protein in hair follicle cells of a subject. The invention also provides for transgenic animals with aberrancies in CADI 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase CADI 1 expression.
    Type: Application
    Filed: November 19, 2007
    Publication date: November 20, 2008
    Inventor: Angela M. Christiano
  • Nucleic acids for inhibiting hairless protein expression and methods of use thereof
    Patent number: 7423022
    Abstract: The present invention provides DNAzymes and ribozymes that specifically cleave Hairless Protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: September 9, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Angela M. Christiano
  • Nucleic acids for inhibiting hairless protein expression and methods of use thereof
    Publication number: 20030077614
    Abstract: The present invention provides DNAzymes and ribozymes that specifically cleave Hairless Protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translation of Hairless Protein mRNA. The invention also provides various methods of inhibiting the expression of Hairless Protein. Finally the invention provides pharmaceutical compositions containing the instant DNAzymes, ribozymes and antisense oligonucleotides as active ingredients.
    Type: Application
    Filed: April 12, 2002
    Publication date: April 24, 2003
    Inventor: Angela M. Christiano