Abstract: In some embodiments, a reconstitution or medicinal fluid delivery device includes a transfer engine including two fluidly connected spikes, each configured to pierce a container. A check valve may be disposed between the two spikes to allow unidirectional flow from one container to the other. Physical access to a fluid outlet may be obstructed by a housing until the reconstitution or medicinal fluid delivery device is actuated, whereupon physical access to the fluid outlet is permitted. The reconstitution or medicinal fluid delivery device may be placed on a flat surface and actuated with force applied in a single direction toward the flat surface.

Abstract: The invention offers an ultracapacitor-based power system solution with four main functional blocks which are power conditioning block, monitoring block, charge-discharge block and protection block. The proposed system has the advantage of working well in the environment of vibration, high temperature, has a large capacity to provide a large amount and radiates less heat compared to systems using traditional batteries. In addition, the system has functions to protect and stabilize the output voltage, and the operating parameters of the system is monitored continuously.

Abstract: Method of analysis text message syntactically and by content, which entails: step 1; Split syntaxes (made available to subscribers by the network operator) into tokens to store in a Syntax Trie; step 2. Pre-process an incoming text from a subscriber; step 3. Split the text (pre-processed in Step 2) into tokens; step 4. Look up paths that include the tokens (obtained in Step 3) in the Syntax Trie (initialized in Step 1); step 5: Return the look-up result, which is the path in the Syntax Trie that best reflects the user intent.

Abstract: Methods and systems are disclosed for quantizing images using machine-learning. A plurality of input images are received from a sensor (e.g., a camera), wherein each input image includes a plurality of pixels. Utilizing an image-to-image machine-learning model, each pixel is assigned a new pixel color. Utilizing a mixer machine-learning model, each new pixel color is converted to one of a fixed number of colors to produce a plurality of quantized images, with each quantized image corresponding to one of the input images. A loss function is determined based on an alignment of each input image with its corresponding quantized image via a pre-trained reference machine-learning model. One or more parameters of the image-to-image machine-learning model and the mixer model are updated based on the loss function. The process repeats, with each iteration updating the parameters of the image-to-image machine-learning model and the mixer model, until convergence, resulting in trained models.

Abstract: The present invention provides a noise modeling method to improve the speech recognition quality to help the recognition system perform better in real-life environments. With this method, we not only add noise to the training audio signal to simulate different environments, but we also add noise labels to the speech transcripts. Since then, the recognition model will perform better in different environments and increase the accuracy of the recognition model.

Abstract: Aspects of the present disclosure relate generally to isolator devices, components thereof, and methods associated therewith for substrate processing chambers. In one implementation, a substrate processing chamber includes an isolator ring disposed between a pedestal and a pumping liner. The isolator ring includes a first surface that faces the pedestal, the first surface being disposed at a gap from an outer circumferential surface of the pedestal. The isolator ring also includes a second surface that faces the pumping liner and a protrusion that protrudes from the first surface of the isolator ring and towards the outer circumferential surface of the pedestal. The protrusion defines a necked portion of the gap between the pedestal and the isolator ring.

Abstract: A system, a method, a device, and an apparatus include a control unit configured to determine contact resistance of one or more electrical contacts of one or more circuits, and remove, via a wetting current, residue on the one or more electrical contacts.

Abstract: The present disclosure relates to site-specific disrupting agents for modulating, e.g., decreasing, expression of a target plurality of genes in a cell. In some embodiments, the target plurality of genes comprises pro-inflammatory genes, e.g., CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, and IL-8. In some embodiments, the method comprises using a first site-specific disrupting agent that targets a first anchor sequence and a second site-specific disrupting agents that disrupts a second anchor sequence.

Abstract: Disclosed herein are various optimized nucleic acids encoding the fukutin-related protein (FKRP). Recombinant vectors comprising the optimized nucleic acid (e.g. operatively linked to a muscle specific promoter), such as recombinant adeno-associated virus vectors, for expressing the protein (e.g. in skeletal and cardiac muscle), and therapeutic compositions contains the vectors are also disclosed. Therapeutic methods of administration of the vectors to a subject for the treatment of a subject with a dystroglycanopathy disorder (e.g., limb-girdle muscular dystrophy 2I) are also disclosed.

Abstract: Provided are a provisioning method for cloud service and a system thereof. The provision method according to some embodiments may include collecting a resource utilization rate of each of a plurality of cloud nodes, receiving a regular instance request from a client, determining whether there is a cloud node among the plurality of cloud nodes that satisfies a first condition, in which the collected resource utilization rate is less than a first threshold value, designating a specific cloud node from among the plurality of cloud nodes based on a determination that there is no cloud node that satisfies the first condition, and terminating at least some of spot instances pre-provisioned on the specific cloud node and provisioning a requested regular instance.

Abstract: A power mesh structure for an integrated circuit is provided. A power switch cell is installed on the chip of the integrated circuit to control the switching operations of the power domain. The power meshes of the power mesh structure is specially designed. The power wires with different electrical properties are arranged in the same column or the same row to reduce the layout area of the power mesh on the material layer.

Abstract: Coronavirus Disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The present invention provides a method and a composition for preventing and treating COVID-19 (SARS-CoV-2) coronavirus infection which includes administering to a subject in need thereof one or more therapeutically effective doses of Virofree which comprises a pharmaceutically acceptable combination of grape seed extract, acerola cherry extract, olive leaf extract, marigold extract, green tea extract, pomegranate extract, yeast beta-glucan and soya bean extract for a treatment period.

Abstract: A multi-material printer for using multiple materials, e.g., bioinks, to quickly fabricate structures, such as high-throughput screening microfluidic chips. The printer’s light projector for emits light in an exposure sequence to cure material in an additive manufacturing process. The printer further includes a motion stage operable to move a build platform into and out of the reservoir in coordination with the exposure sequence. The printer further includes an indexing stage having a work table for supporting the reservoir. The indexing stage is operable to selectively align the build platform with multiple different materials of the reservoir. The multiple materials may be arranged at distinct angular positions within a single reservoir, and the indexing stage may be operable to rotate the work table to align the build platform with different materials during the exposure sequence for a quick transition among different materials without refilling of materials, exchange of reservoirs, etc.

Abstract: The present invention is based, in part, on the discovery of anti-VSIG4 composition (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-VSIG4 compositions for therapeutic, diagnostic, prognostic, and screening purposes.

Abstract: In some embodiments, a reconstitution or medicinal fluid delivery device includes a transfer engine including two fluidly connected spikes, each configured to pierce a container. A check valve may be disposed between the two spikes to allow unidirectional flow from one container to the other. Physical access to a fluid outlet may be obstructed by a housing until the reconstitution or medicinal fluid delivery device is actuated, whereupon physical access to the fluid outlet is permitted. The reconstitution or medicinal fluid delivery device may be placed on a flat surface and actuated with force applied in a single direction toward the flat surface.

Abstract: Apparatuses (e.g., devices, systems, etc.) and methods that may provide access to one or more tools to a remote site in the body including expandable and external working channels that may be part of a tube that is coupled to an outer surface of an elongate medical device, such as an endoscope.

Abstract: In one embodiment, at least a processing chamber includes a perforated lid, a gas blocker disposed on the perforated lid, and a substrate support disposed below the perforated lid. The gas blocker includes a gas manifold, a central gas channel formed in the gas manifold, a first gas distribution plate comprising an inner and outer trenches surrounding the central gas channel, a first and second gas channels formed in the gas manifold, the first gas channel is in fluid communication with a first gas source and the inner trench, and the second gas channel is in fluid communication with the first gas source and the outer trench, a second gas distribution plate, a third gas distribution plate disposed below the second gas distribution plate, and a plurality of pass-through channels disposed between the second gas distribution plate and the third gas distribution plate.

Abstract: Softgel capsules have a fill composition that administers a 200 to 500 mg dose of magnesium from magnesium oxide and an outer sofgel gelatin shell. The composition includes 55 to 70% w/w of an edible oil, 2 to 8% w/w polysorbate 80, 0.5 to 2% w/w hydrophobic silica, and 0.2 to 4% w/w of a chelating agent for binding to magnesium. The softgel capsules have a dissolution according to USP <711> of greater than NLT 75% (Q).

Abstract: The invention presents a system and a method for 3D human reconstruction using a compact kit of depth cameras. Instead of using complex and expensive devices as in traditional methods, the proposed system and method employs a simple, easy-to-install system to accurately collect the human body shape. The generated model is capable of moving thanks to a skeleton system simulating the human skeleton. The proposed system includes four blocks: Data Collection Block, Point Cloud Standardization Block, Human Digitization Block and Output Block. The proposed method includes five steps: Point Cloud Collecting, Point Cloud Filtering, Point Cloud Calibrating, Point Cloud Optimizing and 3D Human Model Generating.