Abstract: The invention provides a biaxially oriented film comprising a multimodal high density polyethylene (HDPE), wherein the multimodal HDPE has a density determined according to ISO 1183 in the range of 952 to 968 kg/m3 and an MFR2 of 0.3 to 3.0 g/10) min when measured at 190° C. with a load of 2.16 kg according to ISO 1133, and wherein the multimodal HDPE comprises at least two fractions: (C) 30 to 70 wt % relative to the total weight of the multimodal HDPE, of a lower molecular weight fraction being a polyethylene with a density in the range of 955 to 980 kg/m3 and an MFR2 of 100 to 2000 g/10 min when measured at 190° C. with a load of 2.16 kg according to ISO 1133; and (D) 30 to 70 wt % relative to the total weight of the multimodal HDPE, of a higher molecular weight fraction being a polyethylene with a density in the range of 925 to 970 kg/m3 and an MFR2 of 0.0001 to 1.0 g/10 min when measured at 190° C. with a load of 2.16 kg according to ISO 1133.

Abstract: Provided is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, that is a modulator of 5-HT2A and can be used in treating diseases and disorders associated with 5-HT2A serotonin receptor expression and/or activity. Thus, also provided are methods of treating 5HT2A-related diseases and disorders.

Abstract: Methods and apparatus for reducing mode conversion associated with differential signals are disclosed. An example method includes providing a common mode dither signal between a first terminal and a second terminal associated with a differential signal, generating a correlation signal representing a correlation of the common mode dither signal and the differential signal, and selectively incrementing a first capacitive loading at the first terminal or a second capacitive loading at the second terminal based at least in part on the correlation signal.

Abstract: The present invention relates to optimized nucleotide sequence encoding SARS-COV-2 antigens. These sequences are particularly suitable for use in vaccine compositions for the treatment or prevention of infections caused by a ?-coronaviruses, including COVID-19 infections, in a human or animal subject in need of such treatment.

Abstract: Mixed-plastics polypropylene blend including mainly polypropylene being benzene free with defined CIELAB color.

Abstract: The present invention relates to a polymer composition suitable for coating a polyolefin fabric substrate comprising the following components: A) 5 to 35 wt.-% based on the overall weight of the polymer composition of a recycled polyolefin fabric substrate; wherein said fabric substrate is coated with a polyolefin composition comprising the following components: a1) an ethylene based plastomer with a density determined according to ISO 1183-1 in the range of 0.857 to 0.915 g/cm3 and a MFR2 (190° C. 2.16 kg) determined according to ISO 1133 in the range of 0.5 to 30 g/10 min; and a2) a propylene based plastomer with a density determined according to ISO 1183-1 in the range of 0.850 to 0.910 g/cm3 and a MFR2 (230° C. 2.16 kg) determined according to ISO 1133 in the range of 0.01 to 30 g/10 min; B) 65 to 95 wt.

Abstract: A process for producing a multimodal ethylene polymer comprising the steps of (i) polymerising ethylene in a first polymerisation step in the presence of a Ziegler-Natta polymerisation catalyst to produce a first ethylene homopolymer (PEI) having a melt flow rate MFR2 of from 100 to 300 g/10 min (ISO 1133-1 at 190° C. under 2.

Abstract: Several heart wall remodeling devices and methods are disclosed. One heart wall remodeling device includes an anchoring portion having an elongated anchor body with a distal anchor end portion and a proximal anchor end portion opposite the distal anchor end portion, a rotation joint portion having a distal joint end portion fixedly attached to the proximal anchor end portion and a proximal joint end portion opposite the distal joint end portion and a hemostasis element having a distal hemostasis end portion detachably connected to the proximal joint end portion. One heart wall remodeling device includes a tensioner that applies a variable tension between anchors.

Abstract: Polyethylene blend with defined CIELAB color.

Abstract: 5G provides for interworking with the 4G/LTE networks, which provides for mobility of user equipment between the 5G and 4G/LTE networks. Mobility from 5G to 4G/LTE requires deregistering user equipment from the 5G core network (5GC) by communicating a deregistration notification from the Evolved Packet Core (EPC) to the 5GC. Systems and methods disclosed herein provide for an optimized deregistration process through avoidance of redundant deregistration notification traffic injected into the 5G network by utilizing 4G/LTE connectivity information to determine whether or not to inject deregistration notifications into the 5G network.

Abstract: The present invention provides, among other things, improved methods and pharmaceutical compositions for treating cystic fibrosis based on codon optimized mRNA encoding an engineered or mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein.

Abstract: Mixed-plastics polypropylene blend including mainly polypropylene being benzene free with defined CIELAB color.

Abstract: Multilayer film which comprises a core layer (C) and two outer layers (0-1, 0-2) sandwiching the core layer, wherein (i) the core layer (C) comprises 90 to 100% by weight of a first bimodal ethylene/1-butene/C6-C12-alpha-olefin terpolymer having a density between >925 kg/m3 and 970 kg/m3 with respect to the total weight of the layer, (ii) two outer layers (0-1) and (0-2) comprise (ii-1) the bimodal terpolymer as defined for the core layer (C) and (ii-2) a second bimodal ethylene/1-butene/C6-C12-alpha-olefin terpolymer having a density between >910 kg/m3 and <925 kg/m3.

Abstract: The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure and related disorders thereto.

Abstract: Methods and apparatus for processing signals captured by one or more sensors are disclosed. An example method includes receiving a first signal from a control circuit, the first signal including control data associated with the one or more sensors, recovering a fixed frequency clock signal and a control signal from the first signal, generating a spread spectrum clock signal based on the fixed frequency clock signal, receiving a sensor data signal based at least in part on data captured by the one or more sensors, the spread spectrum clock signal, and the control signal, retiming the sensor data signal based at least in part on the spread spectrum clock signal and the fixed frequency clock signal, and generating an output signal based on the retimed sensor data signal.

Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.

Abstract: Methods and apparatus for processing signals captured by one or more sensors are disclosed. An example method includes receiving a first signal from a control circuit, the first signal including control data associated with the one or more sensors, recovering a fixed frequency clock signal and a control signal from the first signal, generating a spread spectrum clock signal based on the fixed frequency clock signal, receiving a sensor data signal based at least in part on data captured by the one or more sensors, the spread spectrum clock signal, and the control signal, retiming the sensor data signal based at least in part on the spread spectrum clock signal and the fixed frequency clock signal, and generating an output signal based on the retimed sensor data signal.

Abstract: Polyolefin (PO) compositions derived from post-consumer recyclate (PCR) PO based materials having well balanced properties with regards to electric conductivity, impact performance, stiffness, and workability.

Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.