Abstract: Several methods of supporting respiratory function of a patient before, during and/or after a medical procedure are disclosed. In certain arrangements, supporting respiratory function while a patient is under general anaesthesia can include providing a high gas flow a high gas flow that is greater than 15 L/min while the patient is under general anaesthesia.

Abstract: A compound which is a benzimidazolyl isoxazole of formula (I): wherein: R0 and R, which are the same or different, are each H or C1-6 alkyl; R9, R9 and R9, which are the same or different, are each H or F; X is -(alkn-, -alk-C(?O)—NR—, -alk-NR—C(?O)— or -alk-C(?O)—; R1 is selected from —S(?O)2R?; a 4- to 6-membered, C-linked heterocyclic group which is unsubstituted or substituted; and an N-linked spiro group of the following formula: R2 and R2?, which are the same or different, are each H or C1-6 alkyl, or R2 and R2? form, together with the C atom to which they are attached, a C3-6 cycloalkyl group; R3 and R3, which are the same or different, are each H, C1-6 alkyl, OH or F; R4 is phenyl or a 5- to 12-membered, N-containing heteroaryl group and is unsubstituted or substituted; alk is C1-6 alkylene; R? is C1-6 alkyl; and n is 0 or 1; or a pharmaceutically acceptable salt thereof. The compound has activity in modulating the activity of p300 and/or CBP and is used to treat cancer, particularly prostate cancer.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: An example method for causing a perturbation of blood glucose level in a subject is described herein. The method can include selectively inhibiting neural activity of at least one of a hepatic branch of the subject's vagus nerve or the subject's greater splanchnic nerve using electrical stimulation having a frequency greater than about 5 kHz. The selective inhibition of neural activity causes the subject's blood glucose level to increase or decrease as compared to a baseline level.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: The present invention relates to an adhesive composition comprising at least one deacetylated chitosan, an acid and an additional compound.

Abstract: An example method for causing a perturbation of blood glucose level in a subject is described herein. The method can include selectively inhibiting neural activity of at least one of a hepatic branch of the subject's vagus nerve or the subject's greater splanchnic nerve using electrical stimulation having a frequency greater than about 5 kHz. The selective inhibition of neural activity causes the subject's blood glucose level to increase or decrease as compared to a baseline level.

Abstract: A laryngoscope comprising a handle, a blade holding element, a detachable blade, means for viewing the laryngeal inlet of a patient and means for adjusting the viewing field. The means for adjusting the viewing field may comprise a light refracting means. Alternatively, in embodiments in which the viewing means comprises at least two fixed cameras elements directed to at least two different viewing fields, the means for adjusting the viewing field may comprise means for switching from one camera to the other or, in embodiments in which the viewing means comprises a movable camera element, the means for adjusting the viewing field may comprise mechanical or electronic means for controlling the movement of the camera. A method for viewing the laryngeal inlet of a patient using a laryngoscope comprising the step of adjusting the viewing field is also covered.

Abstract: A method of selectively blocking a portion of a nerve signal is disclosed. The method may include the step of providing an electrode around a subject's peripheral nerve and connecting the electrode to a stimulator. The stimulator may then energize the electrode with a continuous periodic waveform of at least 50 kHz. This energization of the electrode can result in the selective block of one of: 1) a fast portion of a nerve signal having a conduction velocity greater than 2 m/s, and 2) a slow portion of the nerve signal having a conduction velocity less than 2 m/s. A method according to the present disclosure may allow the non-blocked portion of the nerve signal to be conducted substantially unimpeded.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: A guiding device for use with a laryngoscope for assisting in the insertion of an endotracheal tube into a patient, the device comprising a guiding means for guiding an endotracheal tube through the patient's upper airways, and an attachment means to attach the guiding means to the blade of the laryngoscope. A laryngoscope comprising the guiding device is also disclosed.

Abstract: The present invention relates to (2S)-2-({3?-Chloro-4?-[(2,2-dimethylpyrrolidin-1-yl) carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid and (2R)-2-({3?-chloro-4?-[(2,2-dimethylpyrrolidin-1-yl) carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid of formula (I), and crystalline forms and pharmaceutically acceptable salts thereof useful as pharmaceuticals.

Abstract: The present invention relates to an adhesive composition comprising at least one deacetylated chitosan, an acid and an additional compound.

Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

Abstract: Automated medical diagnostic interpretation and report generation for a non-invasive medical diagnostic test, such as an echo cardiogram, is provided. Various dimension measurements and physiological measurements from an echo cardiogram machine are transferred automatically to a computer over an echo cardiogram machine interface. The dimensions and physiological measurements are automatically interpreted by an intelligent interpretation engine running on a computer, generating various machine evaluations. The physician can approve the machine evaluations, overrule them, or make appropriate adjustments. Upon completion of the physician's review, the physician approved interpretations become diagnostic conclusions, and the report containing the results of the physician's review is generated by the report generation engine.

Abstract: A laryngoscope comprising a handle, a blade holding element, a detachable blade, means for viewing the laryngeal inlet of a patient and means for adjusting the viewing field. The means for adjusting the viewing field may comprise a light refracting means. Alternatively, in embodiments in which the viewing means comprises at least two fixed cameras elements directed to at least two different viewing fields, the means for adjusting the viewing field may comprise means for switching from one camera to the other or, in embodiments in which the viewing means comprises a movable camera element, the means for adjusting the viewing field may comprise mechanical or electronic means for controlling the movement of the camera. A method for viewing the laryngeal inlet of a patient using a laryngoscope comprising the step of adjusting the viewing field is also covered.

Abstract: The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.