Abstract: The present invention therefore provides a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition this invention also discloses processes for the preparation of such inhibitors.

Abstract: A method and system of sending supplemental information during a telecommunications session includes the step (305) of detecting a period of silence within the telecommunications session. The period of silence can be detected from at least one member of the telecommunications session. Comfort noise can be specified within at least one time slot (205) of a plurality of consecutive time slots (205, 210) for a channel over which the period of silence is detected. For at least one other time slot of the channel (210), non-voice data is specified such that the channel includes both comfort noise and other non-voice data during the period of silence. The consecutive time slots (205, 210) can be associated with a data block (200). The non-voice data can be a data payload of the other time slot (210).

Abstract: A method is provided for detecting airflow reversal in a sump system of a gas turbine engine. The method includes positioning a first pressure sensor at a sump vent to sense a discharge flow pressure from a sump within the sump system, positioning a second pressure sensor in the sump to sense a pressure in the sump, comparing the sensed pressures obtained from the first and second pressure sensors to determine a pressure difference, and comparing the pressure difference to a predetermined maximum allowable pressure difference.

Abstract: A frequency management scheme for a hybrid cellular/GPS or other device generates a local clock signal for the communications portion of the device, using a crystal oscillator or other part. The oscillator output may be corrected by way of an automatic frequency control (AFC) circuit or software, to drive the frequency of that clock signal to a higher accuracy. Besides being delivered to the cellular or other communications portion of the hybrid device, the compensated clock signal may also be delivered to a comparator to measure the offset between the cellular oscillator and the GPS oscillator. The error in the cellular oscillator may be measured from the AFC operation in the cellular portion of the device. An undershoot or overshoot in the delta between the two oscillators may thus be deduced to be due to bias in the GPS oscillator, whose value may then be determined.

Abstract: A frequency management scheme for a hybrid cellular/GPS or other device generates a local clock signal for the communications portion of the device, using a crystal oscillator or other part. The oscillator output may be corrected by way of an automatic frequency control (AFC) circuit or software, to drive the frequency of that clock signal to a higher accuracy. Besides being delivered to the cellular or other communications portion of the hybrid device, the compensated clock signal may also be delivered to a comparator to measure the offset between the cellular oscillator and the GPS oscillator. The error in the cellular oscillator may be measured from the AFC operation in the cellular portion of the device. An undershoot or overshoot in the delta between the two oscillators may thus be deduced to be due to bias in the GPS oscillator, whose value may then be determined.

Abstract: The invention includes a method of scheduling cyclic steaming of a group of petroleum-containing wells including: inputting to a production-predicting means a group of data describing at least in part the past cyclic steaming and resulting production of a group of petroleum-containing wells; processing the data in the production-predicting means and outputting a group of production predictions for the group of wells during a future steaming cycle; inputting the group of production predictions into an optimization means; inputting an initial steaming Optimal Cycle Length schedule for the group of wells into the optimization means; processing the group of production predictions and the initial steaming cycle schedule in the optimization means by the steps including: determining a ranking for the initial steaming cycle schedule for the group of production predictions against a pre-determined ranking criteria; producing a group of new steaming cycle schedules based on the ranking of the initial steaming cycle a s

Abstract: A method of manufacturing a free standing perovskite lead scandium tantalate film. A film of lead scandium tantalate is formed on a layer of MgO deposited on a sapphire substrate. The MgO layer is etched by phosphoric acid thereby releasing the lead scandium tantalate film from the substrate.

Abstract: A method is described of manufacturing perovskite lead scandium tantalate comprising the pre-reaction of scandium and tantalum oxides at temperatures between 1000.degree. C. and 1400.degree. C. to form scandium tantalate. The scandium tantalate is then reacted with lead oxide to form the desired perovskite phase lead scandium tantalate. In one embodiment there is described a method for the deposition of perovskite lead scandium tantalate films from metal organic precusors. The availability of metal organic precursors allows the deposition of thin films directly from solution or by MOCVD techniques. One particular material, lead scandium tantalate Pb(Sc.sub.0.5 Ta.sub.0.5)O.sub.3, is described. The principal features of the invention are the deposition of scandium and tantalum components from solution or by MOCVD onto the required substrate. These are then prereacted to yield scandium tantalate.