Abstract: Pocket-size medical spirometer comprising a housing and a measurement unit (MU), for measuring rate of total flow when a user exhales through the spirometer. The MU comprises a fluidic jet oscillator adapted to generate oscillating flow with frequency dependent on the rate of flow therethrough. The MU is disposed within the housing so as to form a bypass flow path defined between an outer surface of the MU and an inner surface of the housing. A measurement flow path is defined through the fluidic jet oscillator, such that the total flow is divided into a bypass flow and a measurement flow, the latter being less than the former at least by an order of magnitude. The spirometer further comprises a pressure or velocity transducer and an electronic circuit adapted to derive the total flow rate or volume from the transducer signal.

Abstract: Computer-implemented methods and systems for creating and managing website content involve, for example, providing a user at a computer terminal a data capture template for a user-selected content type, providing the user at the computer terminal presentation pages using content management tags, allowing the user at the computer terminal to author content using the data capture template, and allowing the user at the computer terminal to deploy the content to a server. Other aspects of the methods and systems for creating and managing website content include, for example, allowing the user to personalize content, allowing the user to embed dynamic content in the middle of static content, allowing the user to refresh the deployed content in real-time without impacting current existing user sessions on the server where content is being deployed.

Abstract: Provided is crystalline ziprasidone HCl and processes for preparation thereof.

Abstract: A method of manufacturing polycrystalline abrasive elements consisting of micron, sub-micron or nano-sized ultrahard abrasives dispersed in micron, sub-micron or nano-sized matrix materials. A plurality of ultrahard abrasive particles having vitreophilic surfaces are coated with a matrix precursor material in a refined colloidal process and then treated to render them suitable for sintering. The matrix precursor material can be converted to an oxide, nitride, carbide, oxynitride, oxycarbide, or carbonitride, or an elemental form thereof. The coated ultrahard abrasive particles are consolidated and sintered at a pressure and temperature at which they are crystallographically or thermodynamically stable.

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract: The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the percaridal space to anchor the distal end portion of the lead body relative to the pericardial tissue.

Abstract: The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein the variables are as defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF)

Abstract: A new and distinct nectarine variety of Prunus persica named ‘NJN100’ is provided. This variety is distinguished from other nectarine varieties by its unique combination of showy flowers, fruit that ripen in early-season, glossy fruit with an attractive red over color and greyed-white ground color, clingstone fruit with a juicy, melting texture and sweet, moderately acidic flavor, and excellent production of firm fruit that maintain their eating quality following cold storage.

Abstract: A single-piece top surface display and integrated front cover for an electronic device. In one embodiment, the cover comprises a thin, flexible, transparent layer coupled with a supporting structure. The flexible layer is supported above a display screen which is coupled with pressure activated sensors located under the display screen. The cover is dust-free, waterproof, and has a flat outer surface that is free of any steps or indentations. Users input data by applying pressure on the cover which causes the display screen to deflect and activate the sensors. The pressure exerted on the sensors is triangulated to register the position of the user input. In another embodiment, the cover is transparent, rigid, and directly contacts the pressure activated sensors which are located in front of the display screen or in the housing behind it. When pressure is applied to the cover, the cover deflects and activates the sensors. In both embodiments, an accelerometer identifies valid input events.

Abstract: The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof.

Abstract: A dual drawstring curtain assembly comprising a first hanging cloth that has a first drawstring attached to the first hanging cloth at a first corner. The first drawstring is also slidingly attached at a first attachment point proximate to the perimeter of the first hanging cloth opposite the first corner. A second drawstring is attached at one end of the first hanging cloth at a second corner that is opposite the first corner. The second drawstring is also slidingly attached at a second attachment point proximate to the perimeter of the first hanging cloth opposite the second corner.

Abstract: The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor and/or ultraspiracle activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising a protective compound derived from a protein of the present invention that inhibits the binding between ecdysone receptor and ecdysone as well as the use of such therapeutic compositions to protect animals from flea infestation.

Abstract: A new and distinct peach variety of Prunus persica named ‘NJ353’ is provided. This variety is distinguished from other peach varieties by its unique combination of showy flowers, fruit that ripen in late-season, attractive fruit with a yellow-orange ground color, freestone fruit with a juicy, melting texture and moderately acidic flavor, and good production of firm fruit that maintain their eating quality following cold storage.

Abstract: A new and distinct peach variety of Prunus persica named ‘NJ352’ is provided. This variety is distinguished from other peach varieties by its unique combination of nonshowy flowers, fruit that ripen in latter part of mid-season, attractive fruit with a yellow-orange ground color, freestone fruit with a juicy, melting texture and moderately acidic flavor, and good production of firm fruit.

Abstract: The present invention relates to an apparatus for treating, refreshing or cleaning fabric articles, especially articles of clothing, linen and drapery.

Abstract: The present invention is a hot runner nozzle design consisting of a nozzle core with slotted flange seated inside a slotted nozzle housing, a nozzle tip seated on the nozzle core, and a nozzle tip seal seated on the nozzle tip. Furthermore, the present invention is a quick assembly hot runner nozzle design. The present nozzle design provides for the easy installation and removal of the nozzle by means of turning and sliding the nozzle. This provides for easy installation or removal of the nozzle when servicing the mold in the machine and without the complete disassembly of the hot runner mold. The seal located on the nozzle tip seals the tip area to avoid plastic leakage. Positioning the seal closer to the gate area also contributes in increased nozzle tip mass thus resulting in a better heat distribution profile along the nozzle tip, and especially in the area closer to the gate.

Abstract: A compound of formula I wherein R1 represents chloro, fluoro or hydroxy as well as optical isomers and racemates thereof as well as pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof, processes for preparing such compounds, their utility in treating clinical conditions associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.

Abstract: Within a distributed data processing domain including a requester data processing node and one or more target data processing nodes, an update synchronization of a domain information file as stored on each target data processing node with each domain information file including a local information file having local information an individual operation of the requester data processing node and a global information file having global information associated with a collective operation of all of the data processing nodes. First, the requester data processing node detects domain update information including local update information or global update information. Second, the requester data processing node synchronizes an update of the local information file or the global information file of each domain information file as stored on the target data processing node(s) based on the respective local update information or the respective global update information of the detected domain update information.