Patents by Inventor Anna Borodovsky

Anna Borodovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting expression of a gene from the Ebola virus
    Patent number: 9187516
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: November 17, 2015
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America, as Represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
    Patent number: 9127275
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the KLF1 gene and the BCL11A gene, and methods of using such dsRNA compositions to inhibit expression of KLF1 and BCL11 A, respectively.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 8, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Tatiana Novobrantseva, Brian Bettencourt, Stuart Milstein, Anna Borodovsky
  • COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20150247143
    Abstract: The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.
    Type: Application
    Filed: April 29, 2015
    Publication date: September 3, 2015
    Inventors: Kevin Fitzgerald, James Butler, Brian Bettencourt, Anna Borodovsky, Satyanarayana Kuchimanchi, Klaus Charisse, Muthiah Manoharan, Martin Maier, Kallanthottathil G. Rajeev, Donald Foster
  • Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
    Patent number: 9029338
    Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: May 12, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Anna Borodovsky, Tatiana Novobrantseva
  • Compositions And Methods For Inhibiting Expression Of CD45 Gene
    Publication number: 20150093417
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Application
    Filed: December 2, 2014
    Publication date: April 2, 2015
    Inventors: Antonin de Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lynn Warfield
  • Compositions and methods for inhibiting expression of CD45 gene
    Patent number: 8912316
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: December 16, 2014
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America as represented by the Army
    Inventors: Antonin De Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lyn Warfield
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20140295449
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: October 21, 2013
    Publication date: October 2, 2014
    Applicant: Tekmira Pharmaceuticals, Inc.
    Inventors: Marco A. Ciufolini, Thomas D. Madden, Michael J. Home, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
    Publication number: 20140243394
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: May 15, 2014
    Publication date: August 28, 2014
    Applicants: Alnylam Pharmaceuticals Inc., The Government of the United States, as Represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of a gene from the Ebola virus
    Patent number: 8735369
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: May 27, 2014
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America, as represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KLF-1 AND BCL11A GENES
    Publication number: 20140018410
    Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the KLF1 gene and the BCL11A gene, and methods of using such dsRNA compositions to inhibit expression of KLF1 and BCL11 A, respectively.
    Type: Application
    Filed: December 9, 2011
    Publication date: January 16, 2014
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Tatiana Novobrantseva, Brian Bettencourt, Stuart Milstein, Anna Borodovsky
  • Compositions And Methods for Inhibiting Expression Of A Gene From the Ebola Virus
    Publication number: 20130225654
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: September 26, 2012
    Publication date: August 29, 2013
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD45 GENE
    Publication number: 20130065943
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 14, 2013
    Inventors: Antonin De Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lyn Warfield
  • Compositions and methods for inhibiting expression of a gene from the ebola virus
    Patent number: 8354390
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: January 15, 2013
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America, as represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Lipid Formulated Compositions and Methods for Inhibiting Expression of a Gene from the Ebola Virus
    Publication number: 20120270921
    Abstract: The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Application
    Filed: August 13, 2010
    Publication date: October 25, 2012
    Inventors: Antonin de Fougerolles, Anna Borodovsky, Tatiana Novobrantseva
  • Compositions and methods for inhibiting expression of CD45 gene
    Patent number: 8288525
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: October 16, 2012
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Antonin de Fougerolles, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Sina Bavari, Kelly Lyn Warfield
  • SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS
    Publication number: 20120225434
    Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.
    Type: Application
    Filed: May 1, 2012
    Publication date: September 6, 2012
    Applicants: ALNYLAM PHARMACEUTICALS, INC., The University of British Columbia, Tekmira Pharmaceuticals Corporation
    Inventors: Marco A. CIUFOLINI, Thomas D. Madden, Michael J. Hope, Barbara Mui, Antonin de Fougerolles, Tatiana Novobrantseva, Anna Borodovsky, Akin Akinc, Mark Tracy, Pieter Rutter Cullis
  • LIPID FORMULATION
    Publication number: 20120101148
    Abstract: The invention features an improved lipid formulation comprising a cationic lipid of formula (A), a neutral lipid, a sterol and a PEG or PEG-modified lipid, where R1 and R2 are independently alkyl, alkenyl or alkynyl, each can be optionally substituted, and R3 and R4 are independently lower alkyl or R3 and R4 can be taken together to form an optionally substituted heterocyclic ring. In one embodiment, R1 and R2 are independently selected from oleoyl, pamitoyl, steroyl, linoleyl and R3 and R4 are methyl. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.
    Type: Application
    Filed: January 29, 2010
    Publication date: April 26, 2012
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Akin Aking, William Querbes, Frances M.P. Wong, Joseph R. Dorkin, Xiaojun Qin, William Cantley, Anna Borodovsky, Soma De, Muthiah Manoharan, Muthusamy Jayaraman, Kallanthottathil G. Rajeev
  • PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS
    Publication number: 20110218334
    Abstract: The invention relates to use of single-stranded phosphorothioate oligonucleotides or non-nucleosidic phosphrothiaote as vehicles or carriers to modulate the biodistribution of iRNA agents.
    Type: Application
    Filed: July 10, 2009
    Publication date: September 8, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Martin Maier, Muthiah Manoharan, Kallanthottathil G. Rajeev, Kevin Fitzgerald, Antonin de Fougerolles, Tatiane Novobrantseva, Anna Borodovsky, Maria Frank-Kamenetsky
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
    Publication number: 20110201671
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) FOR INHIBITING THE expression of a gene from the Ebola virus.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles
  • Compositions and methods for inhibiting expression of a gene from the ebola virus
    Patent number: 7973020
    Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: July 5, 2011
    Assignees: Alnylam Pharmaceuticals, Inc., The United States of America as represented by the Secretary of the Army
    Inventors: Sina Bavari, Kelly Lyn Warfield, Pamela Tan, Anna Borodovsky, Tatiana Novobrantseva, Antonin de Fougerolles