Abstract: A method of producing levoglucosenone from particulate cellulosic material. The method comprises forming a premix of particulate cellulosic material, water, acid and a polar organic solvent. The solvent has a higher boiling point than levoglucosenone. The pre-mix is fed into a pyrolysis reactor, such as a fluidised bed reactor, in which the pre-mix is fluidised by a fluidising gas. The reactor is maintained at a temperature within the range 250° C. to 450° C., and gaseous products and char are withdrawn from the pyrolysis reactor. Levoglucosenone and the polar organic solvent are condensed from the gaseous products, produced by the reactor.

Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.

Abstract: Front end systems and related devices, integrated circuits, modules, and methods are disclosed. One such packaged module includes a multi-mode power amplifier circuit in an interior of a radio frequency shielding structure and an antenna external to the radio frequency shielding structure. The multi-mode power amplifier circuit includes a stacked output stage including a transistor stack of two or more transistors. The multi-mode power amplifier circuit also includes a bias circuit configured to control a bias of at least one transistor of the transistor stack based on a mode of the multi-mode power amplifier circuit. The radio frequency shielding structure can extend above a package substrate. The antenna can be on the package substrate. Other embodiments of front end systems are disclosed, along with related devices, integrated circuits, modules, methods, and components thereof.

Abstract: A lighting device includes a light permeable body which has an aperture through which light enters the body. A light source is moveable relative to the body to enable the lighting device to adopt selectively one of a first configuration and a second configuration. In the first configuration, the light source is positioned over the aperture so that light emitted by the light source passes through the body before illuminating the room. In the second configuration, the light source is spaced laterally from the aperture so that the room is illuminated directly by light emitted from the light source.

Abstract: Shielded module fabrication methods and devices. In some embodiments, a carrier assembly can be provided for processing of packaged modules. The carrier assembly can include a plate having a first side that defines a plurality of openings, and an adhesive layer implemented on the first side of the plate. The adhesive layer can define a plurality of openings arranged to substantially match the openings of the plate, with each opening of the adhesive layer being dimensioned such that the adhesive layer is capable of providing an adhesive engagement between an underside perimeter portion of a package and a perimeter portion about the corresponding opening of the first side of the plate.

Abstract: A unit of luggage configured to ascertain its own weight. The unit of luggage comprises a detection assembly with one sensor assembly disposed around each wheel. Each sensor assembly comprises a housing assembly and a shaft disposed therein. The sensor assembly comprises a sensor housing, a cylinder housing and a cylinder. A load cell sensor is generally disposed within the sensor housing and is operatively disposed adjacent to the shaft such that it may engage the sensor and cause an upward deflection that generates a stress indicative of the weight of the unit of luggage being transferred to the particular, corresponding wheel. The cylinder housing is disposed below the sensor housing and encloses the cylinder, which itself encloses the shaft. A frictional resistance between the shaft and the cylinder permits a controlled movement of the shaft therein and permits a processing unit to ascertain a corresponding weight reading.

Abstract: An apparatus for use in assessing strength of at least one knee flexor muscle of a subject, the apparatus including a support, two securing members, each securing member securing a respective lower leg of the subject in a position that in use is substantially fixed relative to the support and at least one sensor, which in use senses a force indicative of the strength of the at least one knee flexor muscle in at least one leg of the subject while the subject performs an eccentric contraction of the at least one knee flexor muscle.

Abstract: An electronic package is provided. The electronic package includes a substrate configured to receive one or more electronic modules, a first electronic module mounted to a first side of the substrate, a first mold structure extending over at least part of the first side of the substrate; and a group of electrically conductive through-mold connections provided on the first side of the substrate. The first mold structure substantially encapsulates the group of through-mold connections. The group of through-mold connections is exposed through the first mold structure. The group of through-mold connections is configured to couple to a circuit board by a corresponding group of intermediate solder portions. The through-mold connections can have a melting point in excess of a melting point of the intermediate solder portion. Related electronic assemblies, electronic devices, and methods of manufacturing and/or mounting an electronic package are provided.

Abstract: Methods are disclosed for manufacturing electronic packages and electronic assemblies. A method of manufacture can include encapsulating electrically conductive through-mold connections with a mold structure and removing a portion of the mold structure to expose the electrically conductive through-mold connections. The electrically conductive though-mold connections can have a higher melting point than solder connections that can connect the electrically conductive through-mold connections to a circuit board. Related electronic packages, electronic assemblies, electronic devices, and methods of mounting an electronic package to a circuit board are disclosed.

Abstract: Methods are disclosed for mounting an electronic package to a circuit board are disclosed. The electronic package can be mounted to the circuit board by use of intermediate solder portions such that each intermediate solder portion couples a corresponding through-mold connection of the electronic package to the circuit board. The through-mold connections can have a melting point in excess of a melting point of the intermediate solder portions. Related electronic packages, electronic assemblies, electronic devices, and methods of manufacturing electronic packages are disclosed.

Abstract: Spray-dried metal-organic frameworks (MOFs) comprising therapeutic and/or diagnostic metal ions and therapeutic and/or diagnostic organic ligands are described. Both the metal ion and organic ligand can have activity related to the treatment and/or diagnosis of a pulmonary disease or disorder, such as tuberculosis, or another disease related to a pulmonary infection. The MOFs can be adminstered to subjects via inhalation (e.g., as aerosols). Methods of treating and diagnosing pulmonary diseases or disorders are also described.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for determining instances of parity drift in target cloud computing systems as well as determining when instances of parity drift require addressing. For example, in various implementations, a cloud parity drift detection system compiles information about services, configurations, versions, etc. along with additional data from a reference cloud system into a job package and provides the job package to one or more target cloud computing systems. The cloud parity drift detection system can then utilize the job package to compare corresponding information on the reference cloud system to a target data set of the target cloud system to determine instances of parity drift at the target cloud system. Additionally, the cloud parity drift detection system can determine and act when instances of parity drift require addressing.

Abstract: An explosives delivery vehicle for delivering a booster for initiating an explosion of an explosive material in a hole in a floor of a mine pit to an operative depth in the hole. The vehicle comprises a storage assembly for storing a plurality of the boosters, a booster loading assembly for (i) supporting the booster in a delivery position above the hole and (ii) moving the booster downwardly into the hole and inserting the booster at an operative depth in the hole; and a delivery assembly for transporting the booster from the storage assembly to the loading assembly.

Abstract: The technology disclosed directly operates on sequencing data and derives its own feature filters. It processes a plurality of aligned reads that span a target base position. It combines elegant encoding of the reads with a lightweight analysis to produce good recall and precision using lightweight hardware. For instance, one million training examples of target base variant sites with 50 to 100 reads each can be trained on a single GPU card in less than 10 hours with good recall and precision. A single GPU card is desirable because it a computer with a single GPU is inexpensive, almost universally within reach for users looking at genetic data. It is readily available on could-based platforms.

Abstract: Systems and methods are provided for facilitating the presentation of expressive intent and other status information with messaging and other communication applications. The expressive intent is based on expressive effect data associated with the message recipients and/or message senders. The expressive intent can be conveyed through avatars and modified message content. The avatars convey gestures, emotions and other status information and the presentation of the avatars can be reactive to detected state information of the message recipient(s), message sender(s) and/or corresponding messaging device(s).

Abstract: Methods of producing augmented probe system images and associated probe systems. A method of producing an augmented probe system image includes recording a base probe system image, generating the augmented probe system image at least partially based on the base probe system image, and presenting the augmented probe system image. The augmented probe system image includes a representation of at least a portion of the probe system that is obscured in the base probe system image. In some examples, a probe system includes a chuck, a probe assembly, an imaging device, and a controller programmed to perform methods disclosed herein.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for determining instances of parity drift in target cloud computing systems as well as determining when instances of parity drift require addressing. For example, in various implementations, a cloud parity drift detection system compiles information about services, configurations, versions, etc. along with additional data from a reference cloud system into a job package and provides the job package to one or more target cloud computing systems. The cloud parity drift detection system can then utilize the job package to compare corresponding information on the reference cloud system to a target data set of the target cloud system to determine instances of parity drift at the target cloud system. Additionally, the cloud parity drift detection system can determine and act when instances of parity drift require addressing.

Abstract: Various components and subcomponents of a pluggable modular system for electrical junction boxes are described herein. In various embodiments, a jbox interface chassis is configured to be wired and fastened within an electrical junction box to provide a hot-swappable pluggable interface between the wires in the electrical junction box and each of a plurality of hot-swappable pluggable modular devices. The jbox interface chassis may include a front pluggable interface configured to electrically mate with a corresponding rear pluggable interface on a casing of each pluggable modular device. As an example, the jbox interface chassis may include a plurality of slots or holes to receive a corresponding plurality of blades or pins on the casing of each pluggable modular device. Additionally, device adapters are described herein to convert a wide variety of legacy electrical devices into pluggable modular devices.

Abstract: A thermal management system for a vehicle includes a plurality of fluid flow circuits including a heating ventilation and air conditioning (HVAC) circuit circulating a flow of refrigerant therethrough and including an evaporator, a chiller heat exchanger, a first expansion valve located upstream of the evaporator, a second expansion valve located upstream of the chiller heat exchanger, and a heat exchanger located fluidly upstream of the expansion valves. A propulsion cooling circuit circulates a flow of coolant therethrough which is utilized to condition one or more propulsion components of the vehicle. The flow of coolant is directed through the heat exchanger, thus subcooling the flow of refrigerant. A controller is operably connected to one or more control points of the thermal management system and is configured to adjust the one or more control points to achieve a target amount of subcooling of the flow of refrigerant at the heat exchanger.