Abstract: The technology disclosed directly operates on sequencing data and derives its own feature filters. It processes a plurality of aligned reads that span a target base position. It combines elegant encoding of the reads with a lightweight analysis to produce good recall and precision using lightweight hardware. For instance, one million training examples of target base variant sites with 50 to 100 reads each can be trained on a single GPU card in less than 10 hours with good recall and precision. A single GPU card is desirable because it a computer with a single GPU is inexpensive, almost universally within reach for users looking at genetic data. It is readily available on could-based platforms.

Abstract: The medical field of COVID-19 diagnosis relates to methods for detecting SARS-CoV-2 nucleic acids in a sample as well as combinations of oligomers for determining the presence or absence of SARS-CoV-2 in a Sample.

Abstract: A system for genetic editing of a stathmin 2 (STMN2) gene, comprising (i) a Cas12i2 polypeptide or a first nucleic acid encoding the Cas12i2 polypeptide, and (ii) an RNA guide or a second nucleic acid encoding the RNA guide, wherein the RNA guide comprises a spacer sequence specific to a target sequence within an STMN2 gene. Also provided herein are methods for editing a STMN2 gene using the gene editing system disclosed herein and/or for treating diseases associated with the STMN2 gene.

Abstract: An explosives delivery vehicle for delivering a booster for initiating an explosion of an explosive material in a hole in a floor of a mine pit to an operative depth in the hole. The vehicle comprises a storage assembly for storing a plurality of the boosters, a booster loading assembly for (i) supporting the booster in a delivery position above the hole and (ii) moving the booster downwardly into the hole and inserting the booster at an operative depth in the hole; and a delivery assembly for transporting the booster from the storage assembly to the loading assembly.

Abstract: A control system includes a refrigerant recovery module and at least one of a valve control module and a compressor control module. The refrigerant recovery module is configured to generate a refrigerant recovery signal to initiate a recovery of refrigerant from a first heat exchanger of a thermal system for an electric vehicle, and to stop the refrigerant recovery based on a temperature of refrigerant circulating through the first heat exchanger. The valve control module is configured to open a first valve to allow refrigerant to flow through the first heat exchanger in response to the refrigerant recovery signal. The compressor control module is configured to increase a speed of a compressor disposed upstream from the first heat exchanger in response to the refrigerant recovery signal.

Abstract: A thermal management system for a vehicle includes a plurality of fluid flow circuits including a heating ventilation and air conditioning (HVAC) circuit circulating a flow of refrigerant therethrough and including an evaporator, a chiller heat exchanger, a first expansion valve located upstream of the evaporator, a second expansion valve located upstream of the chiller heat exchanger, and a heat exchanger located fluidly upstream of the expansion valves. A propulsion cooling circuit circulates a flow of coolant therethrough which is utilized to condition one or more propulsion components of the vehicle. The flow of coolant is directed through the heat exchanger, thus subcooling the flow of refrigerant. A controller is operably connected to one or more control points of the thermal management system and is configured to adjust the one or more control points to achieve a target amount of subcooling of the flow of refrigerant at the heat exchanger.

Abstract: Packaged modules for use in wireless devices are disclosed. A substrate supports integrated circuit die including at least a portion of a baseband system and a front end system, an oscillator assembly, and an antenna. The oscillator assembly includes an enclosure to enclose the oscillator and conductive pillars formed at least partially within a side of the enclosure to conduct signals between the top and bottom surfaces of the oscillator assembly. Components can be vertically integrated to save space and reduce trace length. Vertical integration provides an overhang volume that can include discrete components. Radio frequency shielding and ground planes within the substrate shield the front end system and antenna from radio frequency interference. Stacked filter assemblies include passive surface mount devices to filter radio frequency signals.

Abstract: Devices for fabrication of shielded modules. In some embodiments, a carrier assembly can be provided for processing of packaged modules. The carrier assembly can include a plate having a first side that defines a plurality of openings, and an adhesive layer implemented on the first side of the plate. The adhesive layer can define a plurality of openings arranged to substantially match the openings of the plate, with each opening of the adhesive layer being dimensioned such that the adhesive layer is capable of providing an adhesive engagement between an underside perimeter portion of a package and a perimeter portion about the corresponding opening of the first side of the plate.

Abstract: Various embodiments are directed to a shuttle configured for use in an AS/RS. In various embodiments, the shuttle comprises: a first load arm and a second load arm configured to retractably extend away from a shuttle body in parallel directions, the first and second load arms each being extendable between a retracted configuration and an extended configuration; a load bed including a load area configured to receive the object; and a retractable mechanical finger provided at a distal portion of the first load arm and configured to facilitate handling of the object, the mechanical finger being hingedly connected to the first load arm using a one-way hinge component that defines a portion of the range of rotational movement of the mechanical finger relative to the first load arm and comprising a spring element that facilitates rotational movement of the finger between an expanded finger position and a retracted finger position.

Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: A charging system for a peripheral device, such as a stylus, including orientation control. The charging system includes charging circuitry and magnets. The magnets are configured so that they attract the peripheral device to an engagement surface when it is in a first orientation relative to the engagement surface so that charging circuitry in a peripheral device portion couples with charging circuitry in a charger portion. The magnets are configured so that they also repel and rotate the peripheral device when it is in a second orientation relative to the engagement surface.

Abstract: Examples are disclosed that relate to image reprojection. One example provides a method, comprising receiving a first rendered image comprising content associated with a viewer reference frame, receiving a second rendered image comprising content associated with a manipulator reference frame, and reprojecting the first rendered image based on a head pose of a user to thereby produce a first reprojected image. The method further comprises reprojecting the second rendered image based on the head pose of the user and a pose of the manipulator to thereby produce a second reprojected image, and outputting the first reprojected image and the second reprojected image for display as a composited image.

Abstract: A representative embodiment of a lighting system includes a carrying bag having a first opening with a control panel cover; a mounting bracket arranged in the carrying bag; a power supply coupled to or arranged on the mounting bracket; a control panel arranged within the first opening and coupled to the mounting bracket; a first flexible light strip; a second flexible light strip; and a power cable coupleable within the carrying bag to the control panel, the first flexible light strip, and the second flexible light strip. The first and second flexible light strips are coupleable to the power cable to receive DC power from the control panel, and may be extended throughout a structure, such as a tent, using a plurality of hangers. In a representative embodiment, the first flexible light strip provides white light and the second flexible light strip provides blackout light.

Abstract: In various embodiments, a goods to operator workstation is provided. The goods to operator workstation include an upper level. The upper level includes an upper level conveyor and one or more upper level container bays configured to receive and present one of the one or more upper level containers. The goods to operator workstation also includes at least one connector panel extending from the upper level. The goods to operator workstation further includes a lower level coupled to the at least one connector panel. The lower level is configured to receive one or more lower level containers. A gap is defined between the upper level and lower level that is sized to allow the one or more lower containers to be placed on the lower level. A method of operating the goods to operator workstation is also included.

Abstract: An apparatus and method of mechanical milling and grinding of various materials at temperatures ranging from sub-ambient conditions to well-below their ductile-brittle transition temperature (DBTT) are presented. In one embodiment the present invention entails the design of a cryogenic milling chamber compatible with horizontal high-energy mills. The new design and configuration of the milling vessel provides robust and efficient cryomilling of various materials with no contact between the cryogen and the powders. Some embodiments of the invention improve the heat removal rate from the non-uniform heat load generated by the impact energy deposited into the chamber wall by the milling media.

Abstract: A metering valve for introducing media into a pressurized fluid includes media passaging having a media inlet for receiving media and a media outlet for dispensing media toward the pressurized fluid. The media passaging defines a flow path extending from the media inlet to the media outlet and is configured to permit flow of media along the flow path. A plunger, including a plunger head, is movable between a closed position in which the plunger head forms a seal to prevent flow of media through the media passaging and an open position in which the plunger head permits flow of media through the media passaging. The seal formed by the plunger head includes a first sealing interface and a second sealing interface downstream along the flow path of the first sealing interface.

Abstract: The present invention includes apparatuses and methods for making a final hybrid prosthesis to be attached to one or more dental implants. One preferred method includes the step of making a temporary hybrid prosthesis and at about the same time also making a duplicate temporary hybrid prosthesis. The duplicate temporary hybrid prosthesis permits the final hybrid prosthesis to be made with fewer visits to a restorative dentist and with less dental laboratory time than is currently needed when making a final hybrid prosthesis.

Abstract: This disclosure relates to displaying a user interface for a computing device based upon a user intent determined via a spatial intent model. One example provides a computing device comprising a see-through display, a logic subsystem, and a storage subsystem. The storage subsystem comprises instructions executable by the logic machine to receive, via an eye-tracking sensor, eye tracking samples each corresponding to a gaze direction of a user, based at least on the eye tracking samples, determine a time-dependent attention value for a location in a field of view of the see-through display, based at least on the time-dependent attention value for the location, determine an intent of the user to interact with a user interface associated with the location that is at least partially hidden from a current view, and in response to determining the intent, display via the see-through display the user interface.

Abstract: Systems and methods are provided for facilitating the presentation of expressive intent and other status information with messaging and other communication applications. The expressive intent is based on expressive effect data associated with the message recipients and/or message senders. The expressive intent can be conveyed through avatars and modified message content. The avatars convey gestures, emotions and other status information and the presentation of the avatars can be reactive to detected state information of the message recipient(s), message sender(s) and/or corresponding messaging device(s).

Abstract: An electronic package is provided. The electronic package comprises a substrate having a first side and a second side, the substrate configured to receive one or more electronic components; a first electronic component mounted to the first side of the substrate; a first mold structure extending over at least part of the first side of the substrate; a group of through-mold connections provided on the first side of the substrate, the through-mold connections substantially formed of non-reflowable electrically conductive material; the first mold structure substantially encapsulating the group of through-mold connections; the group of through-mold connections exposed through the first mold structure. An electronic device comprising such an electronic package is also provided. A method of manufacturing such an electronic package is also provided.