Abstract: A smokeless tobacco-free snuff product and method that utilizes a mixture of green or black tea with extracted nicotine and caffeine in a small pouch to be inserted and consumed between a consumer's cheek or gum. The mixture of nicotine, caffeine and tea provides a source of nicotine for consumption with reduced hazards that are normally associated with tobacco products. The present invention combines finely ground green or black tea with nicotine and caffeine in a pulverized dip that may be pinched and placed between the lip and gum of the consumer thus providing a non-toxic source of nicotine.

Abstract: This invention relates to a DNA sequence encoding a member of the hyperpolarized activated ion channel family (HCN) and variants thereof, and the use of said sequences in assays for the measurement of gene expression. It also relates to assays for screening of Ih activators and blockers for clinical and therapeutic use in the management of human psychiatric and neurological dysfunction in the CNS, cardiovascular dysfunction of the heart, and reproductive dysfunction and/or contraception related to Ih function in testes and spermatozoa. Further, antibodies against the expressed DNA sequences and other compounds reactive with the expressed DNA sequence are also part of the invention.

Abstract: This invention relates to a DNA sequence encoding a member of the hyperpolarised activated ion channel family (HCN) and variants thereof, and the use of said sequences in assays for the measurement of gene expression. It also relates to assays for screening of Ih activators and blockers for clinical and therapeutic use in the management of human psychiatric and neurological dysfunction in the CNS, cardiovascular dysfunction of the heart, and reproductive dysfunction and/or contraception related to Ih function in testes and spermatozoa. Further, antibodies against the expressed DNA sequences and other compounds reactive with the expressed DNA sequence are also part of the invention.