Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression. Also disclosed are pharmaceutical compositions that include XDH RNAi agents and methods of use thereof. The XDH RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the XDH RNAi agents in vivo provides for inhibition of XDH gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by XDH gene expression, such as gout and hyperuricemia.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression. Also disclosed are pharmaceutical compositions that include XDH RNAi agents and methods of use thereof. The XDH RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the XDH RNAi agents in vivo provides for inhibition of XDH gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by XDH gene expression, such as gout and hyperuricemia.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression. Also disclosed are pharmaceutical compositions that include XDH RNAi agents and methods of use thereof. The XDH RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the XDH RNAi agents in vivo provides for inhibition of XDH gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by XDH gene expression, such as gout and hyperuricemia.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Mucin 5AC (MUC5AC) gene. The MUC5AC RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an MUC5AC gene. Pharmaceutical compositions that include one or more MUC5AC RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described MUC5AC RNAi agents to pulmonary epithelial cells, in vivo, provides for inhibition of MUC5AC gene expression and a reduction in MUC5AC production, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including mucoobstructive lung disease such as severe asthma and various cancers.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Receptor for Advanced Glycation End-products (AGER or RAGE) gene. The RAGE RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an AGER gene. Pharmaceutical compositions that include one or more RAGE RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described RAGE RNAi agents to pulmonary cells, in vivo, provides for inhibition of AGER gene expression and a reduction in membrane RAGE activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including pulmonary inflammation diseases such as severe asthma.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: Methods of making various fibers are provided including co-axial fibers with oppositely doped cladding and core are provide; hollow core doped silicon carbide fibers are provided; and doubly clad PIN junction fibers are provided. Additionally methods are provided for forming direct PN junctions between oppositely doped fibers are provided. Various thermoelectric generators that incorporate the aforementioned fibers are provided.

Abstract: A compound of formula (I): wherein: Y is (CH2)n, where n is from 2 to 4; W1 and W11 are independently selected from OH and ORP, where RP is Me or Et.

Abstract: A peripheral device includes one or more processors and a memory storing program instructions that when executed implement virtualization offloading components of a virtualized computing service, including a storage manager. The offloading components establish network connectivity with a control plane of the service. Based on detecting that a hardware server, in a separate enclosure, has been linked to the peripheral device, the hardware server is presented as a virtualization host of the service. The offloading components initiate compute instance configuration operations at the server in response to commands issued to the control plane, including at least one configuration operation initiated by the storage manager to enable access to a logical storage device from a compute instance.

Abstract: A compound of formula (I); wherein: W is O or NH; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and OH; the remainder of R A, RB, RC and RD, (if present) are H; RN1 is H or Me; one of RC2 and RC3 is C(?O)NH2; the other is selected from H, Cl, F, Br, Me, OMe, OEt, cyano, CF3, CH2OH, CH2OMe, C2-4 alkenyl and C5heterocyclyl; RC1 and RC4 are independently selected from H, Cl, F, Br, Me, OMe, OEt, cyano, CF3, CH2OH, CH2OMe, C2-4 alkenyl and C5heterocyclyl.

Abstract: A data storage manager may manage storage locations for blocks of a storage volume. The blocks of the storage volume may be assigned to a logical volume exposed to a computing instance supported by a host. Furthermore, the data storage manager may also generate and maintain a set of rules that specify the locations of blocks of the storage volume, and provides the set of rules to the host. The set of rules may be included in a data structure enabling the host to access the blocks based at least in part on the information included in the set of rules.

Abstract: At a virtualization host, an isolated run-time environment is established within a compute instance. The configuration of the isolated run-time environment is analyzed by a security manager of the hypervisor of the host. After the analysis, computations are performed at the isolated run-time environment.

Abstract: Security can be provided for data stored using resources that are deployed in an environment managed by a third party. Physical and logical detection mechanisms can be used to monitor various security aspects, and the resulting security data can be used to identify potential threats to these resources. In some embodiments, suspicious activity can cause resources such as data servers to be automatically and remotely rebooted such that keys stored in volatile memory on those data servers will be lost from those servers, such that an attacker will be unable to decrypt data stored on those servers. Once a determination of safety is made, the keys can be provided to the respective data servers such that data operations can resume.

Abstract: A first instance is caused to execute software code to perform a first portion of a workflow in response to receipt of a workflow request, and performance of the first portion results in submission of an operation request to an entity. A resume workflow request is received from the entity, where the resume workflow request includes a handle to a snapshot that corresponds to a state of execution of the software code and a response to the operation request to the entity. Using the handle to the snapshot and the response to the operation request, a second instance is caused to execute the software code from the first state to perform a second portion of the workflow. A workflow result is received from an instance that executes a last portion of the workflow, and the workflow is provided result in response to the workflow request.

Abstract: At a network manager of an extension resource group of a provider network, a message comprising a command to launch a compute instance is received at an address which is part of a first network configured at a premise external to the provider network. The extension resource group includes a first host at the external premise. Within a second network configured at the external premise, the first host is assigned an address within a second address range. Addresses within the second range are also assigned to hosts within the provider network. The command is transmitted to the first host, and a compute instance is instantiated.

Abstract: A method, system, one or more apparatus, and a computer-readable medium are presented for document review. The system includes a memory; and at least one processor coupled to the memory and configured to receive a written document for review and process the written document for review at a user interface. The system is configured to display the written document at a first portion of the user interface and receive one or more comments about the written document at an entry component at a second portion of the user interface. The system may further generate a document summarizing the comments entered at the user interface and transmit the document to an editor or author.

Abstract: A tailgate enclosure for use with a vehicle can include a plurality of cross-members, a first upright, a second upright, and only one additional upright. Each of the cross-members can be vertically spaced apart from an adjacent one of the cross-members and can include a first beam, a second beam, and a central beam having a first end and a second end, the central beam positioned at least partially between the first and second beams. The first upright can secure the first beam of each of the cross-members to a first sidewall of the vehicle and the second upright can secure the second beam of each of the cross-members to a second sidewall of the vehicle. The additional upright can be positioned along the central beam of each of the cross-members between the first and second ends of the central beam.

Abstract: A first one or more messages is received, the one or more messages including a request for a storage expansion device for an extension of a provider network, an identifier of the extension of the provider network, and a set of one or more identifiers associated with objects to load to the storage expansion device. For each identifier in the set, an object associated with the identifier is copied from an object store of the provider network to the storage expansion device. A shipment of the storage expansion device to a specified location is initiated. The extension of the provider network is caused to launch an instance to communicate with the storage expansion device upon connection of the storage expansion device to the extension of the provider network.

Abstract: An opportunistic hypervisor determines that a guest virtual machine of a virtualization host has voluntarily released control of a physical processor. The hypervisor uses the released processor to identify and initiate a virtualization management task which has not been completed. In response to determining that at least a portion of the task has been performed, the hypervisor enters a quiescent state, releasing the physical processor to enable resumption of the guest virtual machine.

Abstract: A retractable step and side bar assembly that can be used for raised vehicles, such as trucks. The retractable step can be configured to provide for significant reach in a deployed position to allow for a user to enter the raised vehicle. Further, in the stowed position the retractable step can be located within the side bar, thereby providing a low profile as well as an enhanced aesthetic appearance.