Abstract: A merchant can use an e-commerce platform to sell products to customers, and customers can use the e-commerce platform to return items that they are unsatisfied with back to the merchant. These product returns have an associated cost. Embodiments of the present disclosure relate to computer-implemented systems and methods to enable customer-to-customer product returns in an e-commerce platform. In a customer-to-customer return, a first customer that wants to return an item of a particular product is connected with a second customer that wants to purchase that product. The e-commerce platform then facilitates a shipment of the item from the first customer directly to the second customer. Embodiments of the present disclosure include online store implementations of customer-to-customer returns, online marketplace implementations of customer-to-customer returns, and customer-to-customer returns implemented using orders for returned items.

Abstract: Vehicle exterior lighting systems for vehicles equipped with tailgate assemblies may be configured to provide redundant backup lighting functionality for all tailgate positions (e.g., closed, open, and removed). Exemplary systems may include both vehicle static body structure mounted backup lamps and tailgate structure mounted backup lamps for providing the backup lighting redundancy.

Abstract: The present disclosure relates to RNAi agents, for example, double stranded RNAi agents, able to inhibit HIF-2 alpha (EPAS1) gene expression. Also disclosed are pharmaceutical compositions that include HIF-2 alpha RNAi agents and methods of use thereof. The HIF-2 alpha RNAi agents disclosed herein may be linked or conjugated to targeting ligands (such as compounds that have affinity for integrins, including alpha-v-beta-3 and alpha-v-beta-5 integrins) and pharmacokinetic (PK) enhancers, to facilitate the delivery to cells and tissues, including to clear cell renal cell carcinoma (ccRCC) cells and tumors. Delivery of compositions comprising the HIF-2 alpha RNAi agents in vivo provides for inhibition of HIF-2 alpha gene expression. The HIF-2 alpha RNAi agents can be used in methods of treatment of various diseases and disorders, including ccRCC.

Abstract: A first message of a first type and having a first destination address is received in a provider network. The first destination address is associated with a virtual network address of the provider network and an address of a first device in an extension of the provider network, the extension of the provider network in communication with the provider network via at least a third-party network. A message state data store is updated based on at least a portion of the first message. A first payload of the first message is sent to the first device a first secure tunnel through the third-party network.

Abstract: A request to perform a workflow is received. A first instance is caused to be instantiated to perform a first portion of the workflow. First information and a handle associated with a second snapshot is received from the first instance. The first information is processed to produce a first result. A second instance is caused to be instantiated based on the handle to perform a second portion of the workflow. Second information is received from the second instance. The second information is processed to produce a second result, and an operation is performed dependent at least on the first result or the second result.

Abstract: A peripheral device may implement storage virtualization for non-volatile storage devices connected to the peripheral device. A host system connected to the peripheral device may host one or multiple virtual machines. The peripheral device may implement different virtual interfaces for the virtual machines or the host system that present a storage partition at a non-volatile storage device to the virtual machine or host system for storage. Access requests from the virtual machines or host system are directed to the respective virtual interface at the peripheral device. The peripheral device may perform data encryption or decryption, or may perform throttling of access requests. The peripheral device may generate and send physical access requests to perform the access requests received via the virtual interfaces to the non-volatile storage devices. Completion of the access requests may be indicated to the virtual machines via the virtual interfaces.

Abstract: A horizontally moving retractable vehicle step is attachable to a vehicle, such as a low to the ground vehicle like a van. The horizontal vehicle step can provide access to different portions of the vehicle. Further, the horizontal vehicle step can act as a safety mechanism to reduce potential harm to a user in accidentally stepping in gaps between the vehicle and a curb.

Abstract: A door assembly that includes a pocket having a biasing bore configured to accommodate a biasing member; a bezel attached to the pocket; and a door having a cam and at least one axle. The bezel has at least one axle slot. The at least one axle is received into the at least one axle slot and the biasing member is configured to apply an urging force onto the cam.

Abstract: A door assembly that includes a pocket having a biasing bore configured to accommodate a biasing member; a bezel attached to the pocket; and a door having a cam and at least one axle. The bezel has at least one axle slot. The at least one axle is received into the at least one axle slot and the biasing member is configured to apply an urging force onto the cam.

Abstract: A merchant can use an e-commerce platform to sell products to customers, and customers can use the e-commerce platform to return items that they are unsatisfied with back to the merchant. These product returns have an associated cost. Embodiments of the present disclosure relate to computer-implemented systems and methods to enable customer-to-customer product returns in an e-commerce platform. In a customer-to-customer return, a first customer that wants to return an item of a particular product is connected with a second customer that wants to purchase that product. The e-commerce platform then facilitates a shipment of the item from the first customer directly to the second customer. Embodiments of the present disclosure include online store implementations of customer-to-customer returns, online marketplace implementations of customer-to-customer returns, and customer-to-customer returns implemented using orders for returned items.

Abstract: A monitoring device is described. The monitoring device includes a processor. The monitoring device also includes memory in electronic communication with the processor. The monitoring device further includes instructions stored in the memory. The instructions are executable to intercept a lightweight directory access protocol (LDAP) search request sent to an LDAP search handler of a security subsystem from a calling device. The LDAP search request includes a query string containing data for a second protocol. The instructions are also executable to generate response data for the second protocol to substitute for a response by the LDAP search handler. The instructions are further executable to send an LDAP search result to the calling device, the LDAP search result comprising the response data for the second protocol.

Abstract: Indications of packet processing operations to be performed for packets of a resource group, as well as configuration settings of the group, are obtained. A packet that satisfies a requirement of the configuration settings and meets a fast path criterion is processed at a fast path node configured for the group. In response to determining that another packet does not satisfy a criterion for fast path processing, the other packet is transmitted to an exception path target.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of an alpha-ENaC (SCNN1A) gene. The alpha-ENaC RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an alpha-ENaC gene. Pharmaceutical compositions that include one or more alpha-ENaC RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described alpha-ENaC RNAi agents to epithelial cells, such as pulmonary epithelial cells, in vivo, provides for inhibition of alpha-ENaC gene expression and a reduction in ENaC activity, which can provide a therapeutic benefit to subjects, including human subjects.

Abstract: A retractable vehicle step is attachable to a vehicle or truck, such as at the rear portion. The vehicle step facilitates access to a cargo hold of the vehicle. Advantageously, the vehicle step provides clearance space relative to a tailgate of the vehicle by displacing a stepping member of the vehicle step in a generally lateral direction. The vehicle step desirably has a covered and protected biasing mechanism for transitioning between retracted and extended positions of the stepping member. Another advantage is that the vehicle step is readily attachable to the vehicle using already existing connection members, thereby generally eliminating or mitigating the need for customized retrofitting and avoiding undesirable installation cost and time. Further, the vehicle step may be pulled out from under the vehicle by the foot of a user.

Abstract: A horizontally moving retractable vehicle step is attachable to a vehicle, such as a low to the ground vehicle like a van. The horizontal vehicle step can provide access to different portions of the vehicle. Further, the horizontal vehicle step can act as a safety mechanism to reduce potential harm to a user in accidentally stepping in gaps between the vehicle and a curb.

Abstract: A peripheral device may implement storage virtualization for non-volatile storage devices connected to the peripheral device. A host system connected to the peripheral device may host one or multiple virtual machines. The peripheral device may implement different virtual interfaces for the virtual machines or the host system that present a storage partition at a non-volatile storage device to the virtual machine or host system for storage. Access requests from the virtual machines or host system are directed to the respective virtual interface at the peripheral device. The peripheral device may perform data encryption or decryption, or may perform throttling of access requests. The peripheral device may generate and send physical access requests to perform the access requests received via the virtual interfaces to the non-volatile storage devices. Completion of the access requests may be indicated to the virtual machines via the virtual interfaces.

Abstract: Integrin ligands having serum stability and affinity for ?v?6 integrins are described. Compositions comprising ?v?6 integrin ligands having serum stability and having affinity for ?v?6 integrins and methods of using them are also described.

Abstract: A vehicle cargo area lighting system includes, among other things, a cover assembly and at least one cargo area light. The cover assembly is movable back and forth between a closed position and an open position. The cover assembly covers a cargo area of a vehicle when the cover assembly is in the closed position. The cover assembly has a top portion and a wall portion. The wall portion extends vertically downward from the top portion when the cover assembly is in the closed position. The cargo area light is secured to an interior side of the wall portion. The cargo area light is configured to illuminate the cargo area when the cover assembly is in the open position.

Abstract: Systems and methods are described for reducing latency to service requests to execute code on an on-demand code execution system by maintaining snapshots of virtual machine instances in a ready state to execute such code. A user may submit code to the on-demand code execution system, which code depends on other software, such as an operating system or runtime. The on-demand code execution system can generate a virtual machine instance provisioned with the other software, and initialize the instance into a state at which it is ready to execute the code. The on-demand code execution system can then generate a snapshot of the state of the instance, and halt the instance. When a request to execute the code is received, the snapshot can be used to quickly restore the instance. The code can then be executed within the instance, reducing the need to initialize the instance or maintain the instance in an executing state.

Abstract: Systems and methods to improve an e-commerce platform through modifications to the checkout and fulfillment process aimed at reducing the incidence of returns. Modifications may include determining a likelihood of a return and, based on the likelihood of return, generating a staged fulfillment process in which an order is split in two linked orders that are processed serially and based on receipt of confirmation to proceed after delivery of a first one of the orders. Modifications may include determining during the checkout process that a custom return policy is to be used and generating the custom return policy based, at least in part, on one or more of a purchaser return history, the product item or items in the order, and product return history.