Patents by Inventor Anthony P. Burgard

Anthony P. Burgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for synthesis of olefins and derivatives
    Patent number: 9365874
    Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: June 14, 2016
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Priti Pharkya, Stephen J. Van Dien, Anthony P. Burgard, Christophe H. Schilling
  • METHODS FOR INCREASING PRODUCT YIELDS
    Publication number: 20160145652
    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock.
    Type: Application
    Filed: July 22, 2015
    Publication date: May 26, 2016
    Inventors: Anthony P. BURGARD, Robin E. OSTERHOUT, Jun SUN, Priti PHARKYA
  • Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 3-hydroxyisobutyrate or methacrylic acid related thereto
    Patent number: 9346902
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: May 24, 2016
    Assignee: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
  • Microorganisms and methods for the biosynthesis of butadiene
    Patent number: 9321701
    Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: April 26, 2016
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Anthony P. Burgard, Jun Sun, Robin E. Osterhout, Priti Pharkya
  • MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING SUCCINATE RELATED THERETO
    Publication number: 20160083752
    Abstract: Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as succinate. Also provided herein are methods for using such an organism to produce succinate.
    Type: Application
    Filed: October 21, 2013
    Publication date: March 24, 2016
    Inventors: Anthony P. BURGARD, Robin E. OSTERHOUT, Stephen J. VAN DIEN, Cara Ann TRACEWELL, Priti PHARKYA, Stefan ANDRAE
  • Microorganisms for Producing 1,3-Butanediol and Methods Related Thereto
    Publication number: 20160076060
    Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
    Type: Application
    Filed: April 21, 2015
    Publication date: March 17, 2016
    Inventors: Anthony P. BURGARD, Mark J. BURK, Robin E. OSTERHOUT, Jun SUN, Priti PHARKYA
  • Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
    Patent number: 9284581
    Abstract: A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for a sufficient period of time to produce 1,3-BDO.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: March 15, 2016
    Assignee: GENOMATICA, INC.
    Inventors: Anthony P. Burgard, Mark J. Burk, Priti Pharkya
  • METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL
    Publication number: 20160053288
    Abstract: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 25, 2016
    Inventors: Mark J. BURK, Christophe H. SCHILLING, Anthony P. BURGARD, John D. TRAWICK
  • MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL
    Publication number: 20160053287
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 25, 2016
    Inventors: Mark J. BURK, Anthony P. BURGARD, Robin E. OSTERHOUT, Jun SUN
  • ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    Publication number: 20160053286
    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO.
    Type: Application
    Filed: March 30, 2015
    Publication date: February 25, 2016
    Inventors: Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Priti Pharkya
  • Microorganisms and methods for the production of caprolactone
    Patent number: 9267162
    Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: February 23, 2016
    Assignee: Genomatica, Inc.
    Inventors: Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya, Mark J. Burk
  • Primary alcohol producing organisms
    Patent number: 9260729
    Abstract: The invention provides a non-naturally occurring microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: February 16, 2016
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Priti Pharkya, Anthony P. Burgard
  • MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY FORMATE ASSIMILATION
    Publication number: 20160040172
    Abstract: Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH. These microbial organisms can further include a butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol pathway. Additionally provided are methods of using such microbial organisms to produce butadiene, 13BDO, CrotOH, MVC or 3-buten-1-ol.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Inventors: Anthony P. BURGARD, Robin E. OSTERHOUT, Priti PHARKYA, Stefan ANDRAE, Ewa T. LIS, Carla RISSO, John D. TRAWICK
  • MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF FUMARATE, MALATE, AND ACRYLATE
    Publication number: 20160017382
    Abstract: A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme. The one or more gene disruptions confers increased production of acrylate onto the organism. Organisms that produce acrylate have an acrylate pathway that at least one exogenous nucleic acid encoding an acrylate pathway enzyme expressed in a sufficient amount to produce acrylate, the acrylate pathway comprising a decarboxylase. Methods of producing fumarate, malate or acrylate include culturing these organisms.
    Type: Application
    Filed: May 19, 2015
    Publication date: January 21, 2016
    Inventors: Mark J. BURK, Anthony P. BURGARD, Priti PHARKYA
  • Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
    Patent number: 9222113
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: December 29, 2015
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS
    Publication number: 20150368676
    Abstract: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or ?-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB).
    Type: Application
    Filed: January 22, 2015
    Publication date: December 24, 2015
    Applicant: GENOMATICA, INC.
    Inventors: Mark J. BURK, Stephen J. VAN DIEN, Anthony P. BURGARD, Wei NIU
  • MICROORGANISMS AND METHODS FOR THE PRODUCTION OF CAPROLACTONE
    Publication number: 20150353975
    Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
    Type: Application
    Filed: January 13, 2015
    Publication date: December 10, 2015
    Inventors: Anthony P. BURGARD, Robin E. OSTERHOUT, Priti PHARKYA, Mark J. BURK
  • MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING ADIPATE, 6-AMINOCAPROATE, HEXAMETHYLENEDIAMINE OR CAPROLACTAM RELATED THERETO
    Publication number: 20150329885
    Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
    Type: Application
    Filed: December 16, 2013
    Publication date: November 19, 2015
    Inventors: Anthony P. BURGARD, Robin E. OSTERHOUT, Stephen J. VAN DIEN, Cara Ann TRACEWELL, Priti PHARKYA, Stefan ANDRAE
  • Microorganisms for the production of 1,4-Butanediol
    Patent number: 9175297
    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: November 3, 2015
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Jun Sun
  • Microorganisms for producing butadiene and methods related thereto
    Patent number: 9169486
    Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: October 27, 2015
    Assignee: Genomatica, Inc.
    Inventors: Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Jun Sun, Priti Pharkya