Abstract: A drive mechanism of a drug delivery device and a respective drug delivery device for setting and dispensing of a dose of a medicament are presented, where the drive mechanism has an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge containing the medicament, a dosing arrangement manually and axially displaceable relative to the housing for setting and dispensing of the dose, and an accessory drive operably engaged with the piston rod to support a manually operated dose dispensing displacement of the dosing arrangement.

Abstract: A drive assembly for a drug delivery device includes a drive mechanism comprising a piston rod and a drive member to drive the piston rod to dispense a dose of drug and a dose member coupled to the drive member. The assembly further comprises a return mechanism comprising a spring member. The assembly further comprises a movable member which is coupled to the spring member. In a setting, the movable member is coupled to the dose member and, the movable member is movable from an initial position to a dose set position, thereby biasing the spring member. In the dispensing, the drive member and the movable member are decoupled such that the drive mechanism is operable by the user by application of a driving force to the drive mechanism, wherein the spring member of the return mechanism drives the movable member independently of the driving force towards its initial position.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament comprising a clicker arrangement. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) coupled to the dose selector (80) and arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10), a clutch (120) arranged between the number sleeve (60) and the drive sleeve (40), and a dispense clicker comprising a flexible arm (123) and a toothed profile (75). The device further comprises a button (70) operable to effect dose dispensing.

Abstract: A sensor device (2) is removably attachable to a drug delivery device (12). The sensor device comprises an array (20) of optical sensors arranged within the sensor device such that, when the sensor device is attached to the drug delivery device, the drug delivery device having a first movable element (14) which is configured to move along a path parallel to the longitudinal axis of the drug delivery device, each optical sensor is operable to detect light received at different locations along the linear path and to output a signal indicative of an amount of detected light; and circuitry (21) configured to receive the signals output from the optical sensors and, based on the received signals, to determine information associated with a location along the path of the first movable element.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a dose selector (80) operable to set a dose by rotation relative to the housing (10), a number sleeve (60) arranged within the housing (10) such that at least a portion of the number sleeve (60) is visible through a first aperture (11b) in the housing (10), a piston rod (30) coupled to the housing (10) and to a drive sleeve (40) such that rotation of the drive sleeve (40) relative to the housing (10) causes the piston rod (30) to translate relative to the housing (10) and a clutch mechanism arranged between the number sleeve (60) and the drive sleeve (40).

Abstract: The present disclosure is directed to a drive sleeve with a hollow body having a ring of crown teeth with a first outer diameter forming a clutch interface at a first end and a thread extending on an outer surface of the body. The thread has a major diameter and a minor diameter, wherein the ring of crown teeth has at least two cavities. The at least two cavities extend on the outer surface of the body from the first end to the thread and defining a second outer diameter which is smaller than the major diameter of the thread.

Abstract: An injection device includes a housing containing a cartridge containing a medicament and a movable bung. The housing includes an inner thread. The injection device includes a piston rod for moving the bung during dose dispensing. The piston rod includes an outer thread engaging the inner thread of the housing a bearing at its end facing the bung. The injection device further includes a driver coupled to the piston rod for driving the piston rod during dose dispensing. In the unused delivery state of the device, the bearing abuts the bung. The invention further refers to an assembly method for such an injection device.

Abstract: It is provided a drug delivery device (1) comprising: a housing (4), a number sleeve (7) contained within the housing (4) and being rotatable with respect thereto and an axial retention mechanism (6) which is designed to axially restrain the number sleeve (7) to the housing (4) and to allow rotation of the number sleeve (7) with respect to the housing (4), wherein the axial retention mechanism (6) comprises a retention element (11). It is further provided a method of assembly of such a drug delivery device (1).

Abstract: The invention refers to a dispensing speed control mechanism for use in an injection device having a release button, which is displaceable to initiate dispensing of a set dose, a first component part, which is driven by a power reservoir during dose dispensing, and a second component part, which is stationary during dose dispensing. The speed control mechanism includes friction means for retarding the first component part during dose dispensing depending on the position of the release button. Further, the invention refers to a handheld injection device with such a speed control mechanism.

Abstract: A sensor device removably attachable to a drug delivery device includes a sensing arrangement arranged within the sensor device and circuitry configured to process signals provided by the sensing arrangement. The sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to read encoded information present on a rotatable component internal to the drug delivery device and that is able to be sensed through a window or aperture of the drug delivery device, and is operable to sense through the window or aperture at least a part of a drive mechanism of the drug delivery device. The circuitry is configured to determine information relating to a set dose, and to determine information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.

Abstract: A drive mechanism of a drug delivery device and a respective drug delivery device for setting and dispensing of a dose of a medicament are presented, where the drive mechanism has an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge containing the medicament, a dosing arrangement manually and axially displaceable relative to the housing for setting and dispensing of the dose, and an accessory drive operably engaged with the piston rod to support a manually operated dose dispensing displacement of the dosing arrangement.

Abstract: The invention refers to a handheld injection device comprising a housing, a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing, a gauge element, which is at least partly interposed between the housing and the dose indicator, wherein the gauge element is axially guided within the housing and in threaded engagement with the dose indicator such that rotation of the dose indicator causes an axial displacement of the gauge element. A contrast element having a first marking is provided and at least a region of the gauge element is provided with a second marking, with the first marking and/or the second marking being visible through a first window or aperture in the housing depending on the axial position of the gauge element within the housing.

Abstract: The disclosure relates to a drug delivery device for mechanically dispensing a dose of a medicament. The drug delivery device includes a ratchet mechanism adapted to emit an audible and/or tactile feedback during dispensing the dose of medicament. The ratchet mechanism includes a flexible arm and a toothed profile. A free end of the flexible arm is configured to engage with the toothed profile and to perform a relative rotational movement thereto during dispensing the dose of medicament, thereby generating the audible and/or tactile feedback, and the flexible arm extends in a plane parallel to a rotational axis of the flexible arm.

Abstract: The subject matter described herein relates to a supplementary device for attachment to an injection device, the supplementary device comprising: a first imaging arrangement and a second imaging arrangement each configured to capture an image of a moveable number sleeve of the injection device from different respective angles. The supplementary device also comprises a plurality of light sources and a processor arrangement configured to control operation of the first imaging arrangement and the second imaging arrangement and the plurality of light sources and to receive image data from each of the imaging arrangements, wherein the processor arrangement is configured to combine images captured by the first imaging arrangement and the second imaging arrangement into a single image.

Abstract: The disclosure provides a piston rod configured to engage a housing of a drug delivery device, wherein the piston rod comprises an outer thread that corresponds with an inner thread of the housing, characterized by a support element (that is configured as a supplement thread section of the outer thread, wherein the support element comprises a lead-in for assembly of the drug delivery device and wherein the lead-in is distally spaced from another lead-in arranged on the distal outer thread end. The disclosure further provides a drug delivery device comprising such a piston rod and a method for assembling such a drug delivery device.

Abstract: A drug delivery device includes a piston rod which extends along a longitudinal axis of the drug delivery device, wherein the piston rod is adapted to apply an axial load in the distal direction to a cartridge bung in order to dispense a medicament contained in the cartridge. In order to improve the convenience of the injection process and to mitigate the risk of underdosing due to a blocked needle a cartridge bung load indicator is provided, located at the distal end of the piston rod and adapted to abut against the cartridge bung, wherein the cartridge bung load indicator comprises an indicator element that audibly, tangibly and/or visually indicates a load state of the piston rod to the user.

Abstract: A handheld injection device includes a housing and a dose indicator positioned within and axially constrained to the housing and rotatable with respect to the housing during dose setting and during dose dispensing. The dose indicator includes a flexible clicker arm which, only during dispense, is displaced in a first radial direction and, when the device reaches its minimum dose position, in a second, opposite radial direction.

Abstract: The invention refers to a handheld injection device comprising a housing (10; 410), a dose indicator (90; 480) positioned within and axially constrained to the housing (10; 410) and rotatable with respect to the housing (10; 410) during dose setting and during dose dispensing, a gauge element (80; 490), which is at least partly interposed between the housing (10; 410) and the dose indicator (90; 480), wherein the gauge element (80; 490) is axially guided within the housing (10; 410) and in threaded engagement with the dose indicator (90; 480) such that rotation of the dose indicator (90; 480) causes an axial displacement of the gauge element (80; 490). A contrast element having a first marking is provided and at least a region of the gauge element (80; 490) is provided with a second marking, with the first marking and/or the second marking being visible through a first window (12a) or aperture in the housing (10; 410) depending on the axial position of the gauge element (80; 490) within the housing (10; 410).

Abstract: The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).

Abstract: A handheld injection device comprising a housing, a piston rod defining a first longitudinal axis and located within the housing, a driver coupled to the piston rod, a dose setting means, which is rotatable about a second longitudinal axis during dose setting, and optionally a power reservoir for driving the driver and/or a release clutch preventing rotation of the driver during dose setting and allowing rotation of the driver during dose dispensing. The first longitudinal axis is spaced from the second longitudinal axis.