Abstract: A transmission is provided comprising: a first pulley assembly rotatable about a first axis; a second pulley assembly rotatable about a second axis; an endless member coupling the first pulley assembly and the second pulley assembly; an idler pulley engaging the endless member and rotatable about an idler axis, the idler pulley being movable between a first position and a second position; a tensioner assembly coupled to the idler pulley, configured to control tension in the endless member and comprising: a tensioner spring having a spring axis and biasing the idler pulley towards the second position; and a tensioner arm rotatable about a tensioner axis and coupling the tensioner spring to the idler pulley, the tensioner arm defining a spring linkage extending between the tensioner axis and a spring coupling point, wherein a spring angle is defined between the spring axis and the spring linkage.

Abstract: A reactive path planner for vehicles is disclosed. The reactive path planner, based on a nominal path from A to B, generates alternative parallel paths which are displaced by a predefined lateral distance from the nominal path using constrained quintic polynomials. Constraints are imposed on the alternative paths to ensure safety and comfort based on dynamic and mechanical feasibilities of the vehicle. A cost function is applied to the nominal path and alternative paths select the path with the least cost. The reactive path planner achieves a complete path planning solution with high computational efficiency, even in highly cluttered and dynamic environments.

Abstract: A receiving disk for a segmented pulley transmission is provided. The receiving disk comprises: a generally circular body having a pulley facing side and a rear side, opposite the pulley facing side; at least one mating feature located at the pulley facing side of the body, the mating feature being configured to engage a complimentary mating feature, which is secured to a pulley segment of the segmented pulley transmission, when the pulley segment is in an engaged region; and at least one securing feature located in proximity to the mating feature and configured to secure the complimentary mating feature, when the complimentary mating feature is engaged with the mating feature. A segmented pulley transmission comprising the receiving disk is further provided.

Abstract: Disclosed are systems and techniques for fast and efficient detection of defects in wafers, including a system that has a factory interface (FI) coupled to a wafer carrier and a load lock chamber. The FI includes a robot fetches a wafer from the wafer carrier and deliver the first wafer to an aligner device. The aligner device imparts rotational motion to the wafer and identifies, using the rotational motion of the wafer, a position of a reference feature of the wafer. The FI further includes an optical inspection system that collects, during the rotational motion imparted to the wafer, an imaging data for the first wafer. The system further includes a processing device that performs evaluation, using the imaging data, of a presence of defect(s) in the wafer, and evaluates suitability of the wafer for wafer processing.

Abstract: The present disclosure relates to RNAi agents, for example, double stranded RNAi agents, able to inhibit HIF-2 alpha (EPAS1) gene expression. Also disclosed are pharmaceutical compositions that include HIF-2 alpha RNAi agents and methods of use thereof. The HIF-2 alpha RNAi agents disclosed herein may be linked or conjugated to targeting ligands (such as compounds that have affinity for integrins, including alpha-v-beta-3 and alpha-v-beta-5 integrins) and pharmacokinetic (PK) enhancers, to facilitate the delivery to cells and tissues, including to clear cell renal cell carcinoma (ccRCC) cells and tumors. Delivery of compositions comprising the HIF-2 alpha RNAi agents in vivo provides for inhibition of HIF-2 alpha gene expression. The HIF-2 alpha RNAi agents can be used in methods of treatment of various diseases and disorders, including ccRCC.

Abstract: Disclosed are methods for supplementing the processing capabilities of multimedia devices in a networked environment. A method can include providing a processing offloader module to physically connect to a first multimedia device in the networked environment. The offloader can be internal and/or external to the device. The method can include identifying the offloader, identifying a second multimedia device, and determining that a bandwidth of the second device falls below a threshold bandwidth. Instructions can be forwarded from the second device to the offloader when the bandwidth of the second device exceeds the threshold bandwidth. The offloader is configured to process the instructions and render multimedia information based on the instructions.

Abstract: Provided herein are adeno-associated virus (AAV) compositions for correcting a mutation in a beta globin gene (HBB) gene and methods of using the same to correct an HBB gene mutation in a cell. Also provided are packaging systems for making the adeno-associated virus compositions.

Abstract: An actuator system for moving a plurality of pulley segments of a segmented pulley between an engaged region and a disengaged region is provided. The actuator system comprises: a deflector configured to rotate at least between a first position and a second position; and a plurality of followers, each of the followers comprising a protrusion configured to engage the deflector to move the respective one of the pulley segments between the engaged region and the disengaged region, wherein the deflector is configured to move between the first position and the second position to selectively engage the plurality of followers and direct each of the followers between an engaged position and a disengaged position, to move the plurality of pulley segments between the engaged region and the disengaged region. A segmented pulley transmission comprising the actuator system is further provided.

Abstract: A segmented pulley defining an outer peripheral surface for engaging an endless member of a segmented pulley transmission is provided. The segmented pulley comprises: a plurality of pulley segments configured to be sequentially movable between an engaged region and a disengaged region to transition the endless member between the segmented pulley and a concentric pulley in the segmented pulley transmission, each of the pulley segments having a body defining a portion of the outer peripheral surface. The plurality of pulley segments includes a transition segment having an integrated support extending from the body of the transition segment, the integrated support being configured to support the endless member when transitioning the endless member between the segmented pulley and the adjacent pulley in the segmented pulley transmission. A segmented pulley transmission comprising the segmented pulley is further provided.

Abstract: The invention relates to a device for connecting a lighting unit driver (3) to a voltage supply, having a plug (1) comprising: an electric connection terminal (12) for a current supply cable; a housing (11) for receiving the electric connection terminal (12); a plug element (14) on one side of the housing (11) for producing a plug connection, wherein the plug element (14) is electrically connected to the electric connection terminal (12); and a corresponding plug element (2) which is formed directly on a housing (4) of the lighting unit driver (3) and corresponds to the plug element (14) in order to allow a form-fitting and electrically conductive plug connection between the plug element (14) of the plug (1) and the corresponding plug element (2).

Abstract: A network disruption detection engine gathers and stores network routing path update messages that routinely modify routing tables used by internet routers for transporting message traffic between a source and a destination. Routing path messages continually maintain a network transport infrastructure both for intranets used for particular entities such as corporations, and internet traffic between arbitrary source and destination nodes. Major disruptions or outages typically result in an increase in routing path messages, typically focused on a particular set, region or network entity where the disruption occurred, as other routing entities seek to avoid the troubled region. Analysis of this sudden activity of routing messages and extracting message content about the network region they seek to avoid allows identification and queries of a widespread network outage.

Abstract: A segmented pulley transmission with an actuator system is disclosed. The actuator system comprises: an engaging deflector radially movable between first active and idle positions: a disengaging deflector radially movable between second active and idle positions: and a motivator assembly for moving the engaging and disengaging deflectors between the active and idle positions. In the first active position, the engaging deflector is configured to move a plurality of pulley segments of the segmented pulley transmission from a disengaged region to an engaged region during rotational operation of the segmented pulley transmission. In the second active position, the disengaging deflector is configured to move the plurality of pulley segments from the engaged region to the disengaged region during rotational operation.

Abstract: A method and system for autonomous parking are disclosed. The system employs Homography guided motion segmentation (HGMS) to determine the availability of a parking slot. A free parking slot is determined based on an occupancy status check and identified structures of parking lines. For example, motion analysis is performed on successive images captured by a camera unit to determine the occupancy status of a parking slot. Information of the free parking slot, for example, the dimensions and orientation, may be determined from identifying the structure of parking lines. This information is used by the system to guide a vehicle from its current location to the detected free parking slot.

Abstract: A transmission is provided comprising: a first pulley assembly rotatable about a first axis; a second pulley assembly rotatable about a second axis; an endless member coupling the first pulley assembly and the second pulley assembly; an idler pulley engaging the endless member and rotatable about an idler axis, the idler pulley being movable between a first position and a second position; a tensioner assembly coupled to the idler pulley, configured to control tension in the endless member and comprising: a tensioner spring having a spring axis and biasing the idler pulley towards the second position; and a tensioner arm rotatable about a tensioner axis and coupling the tensioner spring to the idler pulley, the tensioner arm defining a spring linkage extending between the tensioner axis and a spring coupling point, wherein a spring angle is defined between the spring axis and the spring linkage.

Abstract: A pulley assembly (120) for engaging an endless member (118) includes a first pulley (124), a second pulley (126) and at least one transition segment set (128, 130) comprising one or more transition segments (152, 162a, 162b) that are independently movable between an engaged region and a disengaged region to transition the endless member (118) between the first pulley (124) and the second pulley (126). An actuator system (122) includes a support structure (220), an actuator subassembly (222, 226) secured to the support structure (220) and a stator (224, 228). The actuator subassembly (222, 226) includes a follower (250) and a sled (248), which is movable in a circumferential direction between an advanced position and a retreated position, in response to an electromotive force generated on the sled (248) by the stator (224, 228).

Abstract: A network disruption detection engine gathers and stores network routing path update messages that routinely modify routing tables used by internet routers for transporting message traffic between a source and a destination. Routing path messages continually maintain a network transport infrastructure both for intranets used for particular entities such as corporations, and internet traffic between arbitrary source and destination nodes. Major disruptions or outages typically result in an increase in routing path messages, typically focused on a particular set, region or network entity where the disruption occurred, as other routing entities seek to avoid the troubled region. Analysis of this sudden activity of routing messages and extracting message content about the network region they seek to avoid allows identification and queries of a widespread network outage.

Abstract: A reactive path planner for vehicles is disclosed. The reactive path planner, based on a nominal path from A to B, generates alternative parallel paths which are displaced by a predefined lateral distance from the nominal path using constrained quintic polynomials. Constraints are imposed on the alternative paths to ensure safety and comfort based on dynamic and mechanical feasibilities of the vehicle. A cost function is applied to the nominal path and alternative paths select the path with the least cost. The reactive path planner achieves a complete path planning solution with high computational efficiency, even in highly cluttered and dynamic environments.

Abstract: An autonomous driving system capable of detecting oncoming occluded vehicles is disclosed in low-light conditions. The system captures images which are processed and analyzed to determine bright spots in a region of interest which are related to reflections of an oncoming occluded vehicle. If an oncoming occluded vehicle is detected, the system analyzes the criticality of the situation based on a tunable threshold distance. The tunable threshold distance from the equipped vehicle (vehicle with the autonomous driving system) to the oncoming occluded vehicle. Factors for tuning the threshold distance may include curvature of the road, sharpness of the turn or occluded area, road surface conditions, speed of the equipped vehicle as well as mechanical capabilities of the equipped vehicle. If the situation is critical, the system generates a warning signal indicating a hazardous condition.

Abstract: A receiving disk for a segmented pulley transmission is provided. The receiving disk comprises: a generally circular body having a pulley facing side and a rear side, opposite the pulley facing side; at least one mating feature located at the pulley facing side of the body, the mating feature being configured to engage a complimentary mating feature, which is secured to a pulley segment of the segmented pulley transmission, when the pulley segment is in an engaged region; and at least one securing feature located in proximity to the mating feature and configured to secure the complimentary mating feature, when the complimentary mating feature is engaged with the mating feature. A segmented pulley transmission comprising the receiving disk is further provided.