Patents by Inventor Antoni Kozlowski

Antoni Kozlowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ORTHOESTER COMPOUND
    Publication number: 20140296541
    Abstract: A compound is provided that is useful for, among other things, preparing water-soluble polymer derivatives bearing a terminal N-succinimidyl ester.
    Type: Application
    Filed: June 12, 2014
    Publication date: October 2, 2014
    Inventor: Antoni Kozlowski
  • Segmented degradable polymers and conjugates made therefrom
    Patent number: 8835599
    Abstract: The present invention provides, among other things, segmented, degradable polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents can have a substantially linear structure, a branched structure, or a multiarm structure. Each structure includes one or more linkages capable of degradation in vivo.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: September 16, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • Hydrolytically stable maleimide-terminated polymers
    Patent number: 8835556
    Abstract: The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: September 16, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • STABILIZED POLYMERIC THIOL REAGENTS
    Publication number: 20140256951
    Abstract: Disclosed are water soluble polymeric thiol reagents. Also disclosed are uses for the polymeric thiol reagents and methods for preparing the polymeric thiol reagents.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Samuel P. McManus
  • Method involving 1-benzotriazolyl carbonate esters of poly(ethylene glycol)
    Patent number: 8816002
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: August 26, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
    Patent number: 8815227
    Abstract: The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: August 26, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • Methods for preparing polymeric reagents and compositions of polymeric reagents
    Patent number: 8809489
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: August 19, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Jon McKannan, Samuel P. McManus
  • Pharmaceutical Compositions of Conjugates Formed From Polymer Derivatives Having Particular Atom Arrangements
    Publication number: 20140227218
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Application
    Filed: December 20, 2013
    Publication date: August 14, 2014
    Applicant: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Method for preparing water-soluble polymer derivatives bearing an N-succinimidyl ester
    Patent number: 8784791
    Abstract: A method is provided for preparing water-soluble polymer derivatives bearing a terminal N-succinimidyl ester. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid and subsequently esterifying the acid.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: July 22, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Hydroxyapatite-targeting poly(ethylene glycol) and related polymers
    Patent number: 8784849
    Abstract: Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: July 22, 2014
    Assignee: Nektar Therapeutics
    Inventors: Michael J. Roberts, Antoni Kozlowski
  • Stabilized polymeric thiol reagents
    Patent number: 8765883
    Abstract: Disclosed are water soluble polymeric conjugates comprising the structure POLY-[Y—S—S-A]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 2, S—S is a disulfide group attached to an sp3 hybridized carbon of Y; and A is a covalently linked residue of a pharmacologically active molecule. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are polymeric reagents useful to prepare such conjugates, and methods of their formation and use.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: July 1, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus
  • Thiol-selective water-soluble polymer derivatives
    Patent number: 8722032
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: May 13, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Intermediates Useful in the Preparation of Maleimide Functionalized Polymers
    Publication number: 20140128619
    Abstract: Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
    Type: Application
    Filed: January 13, 2014
    Publication date: May 8, 2014
    Applicant: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Tracy L. Hutchison, Brian Bray, Xiaoming Shen
  • MULTI-ARM POLYMERIC ALKANOATE CONJUGATES
    Publication number: 20140113961
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 24, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Carbohydrate-based drug delivery polymers and conjugates thereof
    Patent number: 8680263
    Abstract: Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: March 25, 2014
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Xiaoming Shen
  • MALEIMIDYL POLYMER DERIVATIVES
    Publication number: 20140073802
    Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.
    Type: Application
    Filed: November 7, 2013
    Publication date: March 13, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Samuel P. McManus, Antoni Kozlowski, J. Milton Harris
  • Method Involving 1-Benzotriazolyl Carbonate Esters of Poly(ethylene glycol)
    Publication number: 20140051845
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 20, 2014
    Applicant: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Intermediates useful in the preparation of maleimide functionalized polymers
    Patent number: 8653286
    Abstract: Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 18, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Tracy L. Hutchison, Brian Bray, Xiaoming Shen
  • Polymer Derivatives Comprising an Acetal or Ketal Branching Point
    Publication number: 20140039167
    Abstract: The invention conjugates that can be prepared by contacting a polymer comprising an acetal or ketal branching point with a pharmacologically active agent under conditions suitable to form a covalent attachment between the polymer and the pharmacologically active agent.
    Type: Application
    Filed: October 3, 2013
    Publication date: February 6, 2014
    Applicant: Nectar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • POLYMER-DES-ETHYL SUNITINIB CONJUGATES
    Publication number: 20140039030
    Abstract: The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over des-ethyl sunitinib in unconjugated form.
    Type: Application
    Filed: December 23, 2011
    Publication date: February 6, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Sean M. Culbertson, Xiaoming Shen, Samuel P. Mcmanus, Mark A. Wilson