Patents by Inventor Antoni Kozlowski

Antoni Kozlowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complexes of small-interfering nucleic acids
    Patent number: 9089610
    Abstract: The present invention relates to complexes of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: July 28, 2015
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Patrick D. Youso
  • Polymer derivatives comprising an imide branching point
    Patent number: 9085659
    Abstract: The invention provides a water-soluble polymer comprising (i) an imide group comprising a linking nitrogen atom, a first carbonyl group covalently attached to the linking nitrogen atom, and a second carbonyl group covalently attached to the linking nitrogen atom; (ii) a first water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the first carbonyl group of the imide group and (iii) a second water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the second carbonyl group of the imide group. The invention also provides, among other things, methods for preparing polymers, conjugates, pharmaceutical compositions and the like.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: July 21, 2015
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • METHOD INVOLVING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF POLY(ETHYLENE GLYCOL)
    Publication number: 20150191568
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Application
    Filed: August 25, 2014
    Publication date: July 9, 2015
    Inventor: Antoni Kozlowski
  • Orthoester compound
    Patent number: 9045494
    Abstract: A compound is provided that is useful for, among other things, preparing water-soluble polymer derivatives bearing a terminal N-succinimidyl ester.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: June 2, 2015
    Assignee: NEKTAR THERAPEUTICS
    Inventor: Antoni Kozlowski
  • Pharmaceutical compositions of conjugates formed from polymer derivatives having particular atom arrangements
    Patent number: 9044516
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 2, 2015
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Thiol-selective water-soluble polymer derivatives
    Patent number: 9040658
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 26, 2015
    Assignee: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • MULTI-ARM POLYMERIC ALKANOATE CONJUGATES
    Publication number: 20150133534
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Application
    Filed: January 7, 2015
    Publication date: May 14, 2015
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • Heterobifunctional Poly(ethylene glycol) Derivatives and Methods for Their Preparation
    Publication number: 20150107489
    Abstract: This invention provides a method related to the preparation of derivatives of poly(ethylene glycol).
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Applicant: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • ACID SALT FORMS OF POLYMER-DRUG CONJUGATES AND ALKOXYLATION METHODS
    Publication number: 20150105519
    Abstract: Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
    Type: Application
    Filed: May 21, 2014
    Publication date: April 16, 2015
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Anthony O. Chong, Seoju Lee, Bhalchandra V. Joshi, Brian Bray, Shaoyong Nie, Patrick L. Spence, Antoni Kozlowski, Samuel P. McManus, Sachin Tipnis, Greg Lavaty, David Swallow, John R. Handley, Anthony G. Schaefer
  • Multi-arm polymeric alkanoate conjugates
    Patent number: 8962566
    Abstract: Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related methods of making and administering the same. Methods of treatment employing such conjugates and related uses are also provided. The conjugates are prepared with high drug loading efficiencies.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: February 24, 2015
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Samuel P. McManus, Jennifer Riggs-Sauthier, Xiaoming Shen, Wen Zhang
  • CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF
    Publication number: 20150051371
    Abstract: Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.
    Type: Application
    Filed: January 29, 2014
    Publication date: February 19, 2015
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Samuel P. McManus, Xiaoming Shen
  • Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
    Patent number: 8940801
    Abstract: This invention provides a method related to the preparation of derivatives of poly(ethylene glycol), wherein the method comprises increasing the pH of an aqueous composition comprising a poly(ethylene glycol) bearing a —O—(CH2)n—CO2R3 functional group to result in an aqueous composition comprising a poly(ethylene glycol) bearing a —O—(CH2)n—CO2H functional group, wherein R3 is alkyl and (n) in each instance is 1-6.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: January 27, 2015
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, J. Milton Harris, Antoni Kozlowski
  • Monoconjugated chitosans as delivery agents for small interfering nucleic acids
    Patent number: 8916693
    Abstract: Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly(ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: December 23, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Patrick D. Youso
  • Method for preparing branched functionalized polymers using branched polyol cores
    Patent number: 8901246
    Abstract: A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: December 2, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • Intermediates useful in the preparation of maleimide functionalized polymers
    Patent number: 8895759
    Abstract: Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: November 25, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Tracy L. Hutchison, Brian Bray, Xiaoming Shen
  • THIOL-SELECTIVE WATER-SOLUBLE POLYMER DERIVATIVES
    Publication number: 20140330041
    Abstract: The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins, as well as methods for preparing the water-soluble, polymer derivatives having a thiol-selective terminus.
    Type: Application
    Filed: March 28, 2014
    Publication date: November 6, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Antoni Kozlowski, Remy F. Gross, III, Samuel P. McManus
  • Hydroxyapatite-Targeting Multiarm Polymers and Conjugates Made Therefrom
    Publication number: 20140329990
    Abstract: The present invention provides, among other things, polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains and a plurality of hydroxyapatite-targeting moieties, and optionally the reagents include one or more degradable linkages that serve to divide the polymer chains into polymer segments having a molecular weight suitable for renal clearance.
    Type: Application
    Filed: July 18, 2014
    Publication date: November 6, 2014
    Applicant: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski
  • METHODS FOR PREPARING POLYMERIC REAGENTS AND COMPOSITIONS OF POLYMERIC REAGENTS
    Publication number: 20140323742
    Abstract: Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Inventors: Antoni Kozlowski, John McKannan, Samuel P. McManus
  • Polymeric reagents comprising a ketone or a related functional group
    Patent number: 8865149
    Abstract: Polymeric reagents comprising a polymer attached, either directly or through one or more atoms, to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: October 21, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Xiaoming Shen, Daniel C. Cook
  • Water-soluble polymer alkanals
    Patent number: 8853325
    Abstract: The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski