Abstract: A non-human transgenic animal having a polynucleotide encoding a PTN polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the PTN polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed.

Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.

Abstract: A non-human transgenic animal having a polynucleotide encoding a PTN polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the PTN polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed.

Abstract: Hydraulic press which comprises: a structure which comprises at least one support for supporting the hydraulic press on the floor, a working table intended to house a set of pieces from which at least one piece is separated or removed by means of a compressive force exerted by the hydraulic press. a collection area positioned below the working table receiving the piece separated or removed from the set, and a damper connected between the working table and the structure, capable of being expanded to cause the ascent of the working table with respect to the structure and is capable of being compressed to allow the retained descent of the working table with respect to the structure.

Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa and RHD*DIVa-2. The method comprises amplifying by PCR a sample obtained from a human subject at intron 3 of the RHD gene locus. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.

Abstract: Electrical appliance that can be used in industry for cooling or freezing products with maximum speed by selecting the desired temperature or time from a control panel. The gas R410A, when introduced into the compressing motor is responsible for compressing the gas of the circuit passing through the coil. The condenser, the first filter dryer, the capillary tube, the evaporator, the second filter dryer being strategically placed for rearranging the particles and molecules, continuing through the coil until returning to the compressing motor. This set of components becoming a single closed circuit, without the need to be recharged. One or more fans are placed on walls or ceiling of the evaporator for transmitting a cold shock or thermal sensation making use of the cold existing within the evaporator. A second filter can be strategically placed for cooling with maximum speed.

Abstract: A microelectromechanical (MEMS) device has a movable member supported above a substrate on a via support. The member and via support are fabricated integrally from first and second member forming layers. A first member forming layer forms a lower part of the member and supporting structure for the via support. First and second fill layers are deposited and patterned to form a plug that fills an inner cavity opening in the via structure. The plug is planarized to a planar part of the first member forming layer, and a second member forming layer is deposited over the first member forming layer and the planarized plug to form an upper part of the member. The via support may have a cavity filled by BARC layers.

Abstract: The present invention relates to a bottle jack comprising a main body and a shaft that expands or contracts, further comprising: a passage space communicating a hydraulically operated circuit with an unloading circuit through which the controlled outlet of hydraulic fluid from the hydraulically operated circuit and subsequent lowering of the shaft occur; a closure element elastically pushed towards the passage space to prevent the outlet of hydraulic fluid therethrough; a ram assembly elastically pushed in the longitudinal backward movement direction (B) with a force greater than the force with which the closure element is elastically pushed against the passage space; and a telescopic lever assembly which can be lowered by a user to operate the hydraulically operated system.

Abstract: The present invention relates to a trolley jack comprising a main body and a lifting element capable of moving up or down for lifting a heavy object, and a lever assembly projecting upwards along a longitudinal axis for allowing a user to manually push and move the jack, where a lower end of the lever assembly is connected in an articulated manner to the main body according to a transverse axis of rotation, the lever assembly being capable of being lowered with respect to said transverse axis of rotation and arranged against the main body. Providing a hinged lever assembly increases jack storage and transport possibilities.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining alternative travel itineraries.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining alternative travel itineraries.

Abstract: A method for resampling time series data includes determining a first time series of data points; determining a variation of the data points within a selected sequence, wherein the variation is determined by determining linearly interpolated data points for the data points of the selected sequence and by determining a maximum absolute difference. If a determined variation is greater than a predetermined error value, subsequences are selected by repeatedly dividing the first time series into adjacent subsequences until the first time series comprises a set of subsequences, wherein a determined variation for each of the subsequences is smaller than the predetermined error value. A resampled time series is created by adding the data points of the first time series that correspond to a first or last data point of the selected subsequences to the resampled time series, wherein every data point is added only once to the resampled time series.

Abstract: Embodiments of ignition systems, apparatus, and/or methods can provide exemplary voltage control or regulation for a voltage used for flame detection as well as for spark generation. In one embodiment, flame sensitivity and spark energy can have an increased resistance to component, temperature, and/or power supply variations.

Abstract: The invention relates to genotyping and blood cell antigen determination. In particular, the invention addresses discriminating the RHD*DIIIa-CE(4-7)-D or RHD*DIIIa-CE(4-7)-D)-like blood type variants, from RHD*DIIIa, RHD*DIVa-2 and other blood type variants. The invention provides methods for genotyping a subject, comprising determining at least 4 markers in a sample that has been obtained from the subject, wherein the markers comprise: (i) the presence or absence of an RHCE*C allele; (ii) the presence or absence of an RHD/RHCE hybrid exon 3 (RHD/CE Hex03) allele; (iii) the absence of, or a single nucleotide polymorphism (SNP) variant within, any one of position 602 of exon 4, position 667 of exon 5, or position 819 of exon 6 of RHD; and (iv) the absence of, or SNP variant within, position 1048 of RHD exon 7. The invention also provides probes, primers and kits for use in such methods.

Abstract: A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.

Abstract: A method for predicting the severity or progression of OA in a human subject, comprising: determining the identity of at least one allele at each of at least 4 positions of single nucleotide polymorphism (SNPs) selected from the group consisting of: rs2206593, rs10465850, rs780094, rs1374281, rs1143634, rs2073508, rs2243250, rs4720262, rs917760, rs7838918, rs12009, rs730720, rs874692, rs893953, rs1799750, rs10845493, rs11054704, rs7986347, rs1802536, rs10519263, rs7342880, rs16947882 and rs10413815, and one or more SNPs in linkage disequilibrium at a level of at least R2?0.8 therewith, as well as products, in particular systems and kits for use in such a method.

Abstract: A method for prognosing recurrence of prostate cancer (PCa) in a subject following prostatectomy using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping PCa associated genetic variations comprising use of a DNA microarray. A microarray for use in the described methods.

Abstract: A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.