Abstract: A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.

Abstract: The present invention provides a wet wipe made up of a substrate impregnated with a cleaning lotion where the cleaning lotion includes a particulate material.

Abstract: It consists of a compact apparatus, easy to install, which allows the optimal dissipation of the heat produced during the electrochemical reaction, composed of a first tank (1) wherethrough water (9) enters and a second tank (2) wherethrough the hydrogen gas (7) and oxygen gas (8) resulting from the electrolysis exit mixed with the water (9), and which includes pipes (3) independent of each other, without superficial continuity therebetween, connecting both tanks (1, 2), the outer surface of which is in direct contact with the air or through the intermediation of dissipating flaps (10) to facilitate the dissipation of the heat generated during the electrolysis.

Abstract: An ignition control and method are provided for overseeing an ignition process on a fuel-fired appliance having a fuel burner, a fuel flow control valve, an ignition source, and a flame detection device. A primary processor initiates the ignition process, monitors the flame status signal and terminates the ignition process in the presence of a flame status signal indicating no flame after a specified period of time following the initiation of the ignition process. A secondary processor monitors the flame status signal independently of the primary processor and terminates the ignition process in the event that the primary processor fails to terminate the ignition process in the presence of a flame status signal indicating no flame after a specified period of time following the initiation of the ignition process. The primary and secondary processors may each have the functional capability to monitor the operation of the other.

Abstract: The invention relates to a dwelling formed by one or more preferably concrete three-dimensional modules (1 and 1?) which are provided with complementary coupling means (7 and 7?) so that the modules can be positioned side by side and/or on top of one another in order to form a dwelling with several rooms or even several dwellings. The invention includes an access (2) to the interior, windows (9) and ports for pipes (3) for chimneys (4), vents and lighting outlets (5). The constituent modules (1 and 1?) of the dwelling(s) are installed in a trench or cave formed in suitable terrain (6) and, except for the access wall containing the door (8) and/or the windows (9), are covered completely with natural soil corresponding to the terrain (6) excavated in order to install the modules (1 and 1?) and the dwelling(s).

Abstract: A method and apparatus for accessing messages y contained in a data store 100 is provided. The method comprises the steps of determining a number of messages y of a predetermined message type forming a structure S consisting of a plurality of said messages y of the predetermined message type in the data store 100, selecting the structure, reading a first bit x of each message y of said structure consecutively, and reading a subsequent bit x+n of each message y of said structure consecutively until a final bit x of each message is read.

Abstract: The invention relates to the use of maslinic acid or natural, synthetic or semi-synthetic maslinic-rich mixtures or of a composition containing said acid for the treatment of pathological processes associated with COX-2 activation, intended, inter alia, for the symptomatic and/or regenerative treatment of arthrosis, rheumatoid arthritis, fibromyalgia, sciatica and other articular disorders that are difficult to diagnose. The invention also relates to the topical administration thereof.

Abstract: The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.

Abstract: The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor.

Abstract: An in vitro method for genotyping genetic variations in a individual, and products for use in the method.

Abstract: Methods for identifying strains of bacteria, particularly methods for serotyping Streptococcus pneumoniae in a sample, methods for detecting and/or classifying S. pneumoniae infection by serotype, array devices and kits for use in such methods are disclosed. Array devices comprise a set of capture antibodies immobilised on a substrate at pre-determined array positions, wherein the set of capture antibodies comprises serotype-distinguishing antibodies which differ in their binding specificity for different S. pneumoniae serotypes. Serotyping methods may employ whole cell detection utilising one or more detectable labels, including in situ labelling of array-bound cells.

Abstract: The invention relates to an “in vitro” method for determining the global genetic risk a subject has of developing a pathology associated with aging. Said method is based on the combination of particular genetic risks of developing common pathologies associated with aging. Said particular genetic risks are determined from the results obtained from the simultaneous genotyping of certain genetic variations associated with said pathologies associated with aging and the main objective of which is the use thereof in anti-aging medicine.

Abstract: The present invention relates to a method and an apparatus for determining which one or more time series parameters of a plurality of time series parameters relating to operation of a system are correlated with a first operation state of the system.

Abstract: A method for making a high fat cream cheese product with enhanced creamy texture. A milk source and an optional fat source can be combined to form a standardized milk base having a first fat level of about 7% or less, which is then inoculated with a bacteria starter culture and fermented. After fermentation, an optional pH adjustment step may be provided, and the pH may be adjusted by addition of a sweet (i.e., unfermented) mix. The fermented milk base is then ultrafiltered, and an ultrafiltration concentrate results having a second fat level greater than the first fat level and up to about 20%. The ultrafiltration concentrate is combined with a sour cream having a fat content greater than about 20%, and the combined mixture is then heated, homogenized, and packaged resulting in a high fat cream cheese product having a fat content greater than about 20%.

Abstract: The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.

Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.

Abstract: A multivariate environmental sensing system with redundant transmission pathways with a network of nodes detecting environmental conditions and processing a transmissible signal. Nodes use predetermined criteria to make periodic detections, maintaining a low power state between detections. Power is conserved by deciding whether detections are transmitted immediately, or may be stored for periodic transmission. The nodes power up and immediately transmit urgent detections, storing routine detections for delayed batch transmission. Nodes may transmit signals received from other nodes, passing along signals received from more distant nodes. Transmission may have a predetermined pattern, but the system alters this pattern if there is disruption to the system or pattern. Gateways process data from nodes and pass data to other gateways, on an immediate or deferred basis, to a control center, where data is analyzed.