Abstract: Embodiments disclosed herein are directed to fixed compositions comprising brimonidine and timolol for lowering intraocular pressure and treating glaucoma.

Abstract: An actuator to execute on a server may be automatically selected based on risk of failure and damage to the server. Requirement specification and environment parameters may be received. A subset of actuators may be selected based on a risk threshold from an actuator catalog database storing actuator information and actuator risk metadata associated with a plurality of actuators. The actuator risk metadata may be augmented with risk information. A ranked list of the subset of actuators may be generated based on the actuator risk metadata associated with each actuator in the subset. An actuator in the ranked list may be executed on the server.

Abstract: A computer-implemented method in accordance with one embodiment includes, in response to a submission of an input dataset to an artificially intelligent application, receiving an explanation from each module of the application. The modules are configured within the application in a serial sequence in which each module, upon receiving the input dataset and any input generated by an immediately preceding module of the serial sequence, generates output that is forwarded as input to a next module, if any, in the sequence. A determination is made that at least two of the received explanations are semantically inconsistent.

Abstract: Improving distribution of traffic from clients to servers is provided. A device intermediary to a plurality of clients and a plurality of servers can receive a request from a client of the plurality of clients to access one of the plurality of servers. The device can determine a hash value based on at least a portion of the request received from the client. The device can identify an index of a plurality of indices listing the plurality of servers repeated a plurality of times in a deterministic shuffled order. The device can apply a cache array routing protocol (CARP) algorithm to a second plurality of servers listed in a subset of the plurality of indices around the index. The device can select a server from the second plurality of servers with a highest hash value based on the application of the CARP algorithm.

Abstract: Managing batched jobs is provided. The method comprises receiving a job batch request from a client for a number of processing jobs. Each job is registered, and jobs that are ready for execution at a specified time are collected. For each collected job an instance of the job is locked to prevent duplicate execution. The locked jobs are queued, and a container is created for each job in the queue. A method of execution is determined for each job in the queue, and each job is then executed according the method determined for that job. Job events for each executing job are logged, a determination if a job was completed successfully is made according to its respective job events. A job status is updated for each completed job. The container of each completed job is then destroyed, and each completed job is unlocked.

Abstract: A method includes receiving, at an artificial intelligence (AI) accelerator of a computing system, at least one of: manufacturer data, third-party data, sensor data, or primary usage data of a consumable in a primary device and performing an AI operation on at least one of: the manufacturer data, the third-party data, the sensor data, or the primary usage data at the AI accelerator of the computing system using an AI model. The method further includes determining a primary life expectancy of the consumable in the primary device at the AI accelerator in response to performing the AI operation.

Abstract: The present disclosure relates to dosing regimens, formulations, and combinations comprising a multispecific antibody having at least binding specificity towards B cell maturation antigen (BCMA) and a T-cell engaging arm; and methods of using such multispecific antibodies in the treatment or prevention of disease, such as, cancer.

Abstract: A system and method for accelerating modernization of user interfaces in a computing environment is disclosed. The method includes receiving request for transforming a current graphical user interface (GUI) corresponding to current programming language and associated software framework to a target GUI corresponding to target programming language and associated software framework. The method includes capturing run time application attributes during an active interactive session of the user interface with user devices. Further, the method includes determining static application attributes from the source code of the current application. The method includes generating application attribute model representing relationships between static application attributes and run time application attributes. The method further includes automatically generating a target application attribute model corresponding to the target programming language and associated software framework based on the application attribute model.

Abstract: Multi-modal, portable, handheld devices for tissue assessment (e.g., wound assessment) are provided, as are methods of fabricating and methods of using the same. The devices can be used for virtual medicine (VM)-based wound management, such as VM-based diabetic foot triage (DFT) and management. The device can be used to take physiological measurements of temperature and/or tissue oxygenation of a wound to assess the wound, for example in a remote setting environment. The device can also be used to provide therapy for tissue repair and/or wound healing, apart from the multi-modal imaging of the tissue surface of the patient. For example, light therapy, such as low-level light therapy (LLLT) can be provided via one or more light emitting diodes (LEDs) and/or laser diodes.

Abstract: A bench top incubator is described. The bench top incubator includes a first tray stack designed to retain microscope slides in a plurality of slide trays and a second tray stack designed to retain multi-well plates in a plurality of plate trays. The incubator is relatively simple and small in design and can be conveniently located to carry out temperature processing of biological samples such as fixed cells and tissues, biological fluids, and so forth.

Abstract: The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Abstract: According to one embodiment, a system includes a first and second cooling system, an automation controller, one or more sensors, and a hardware controller separate from the automation controller. The hardware controller processes various temperature set points in conjunction with a timer and configures the activation or deactivation of the first and second cooling systems accordingly.

Abstract: A cellphone-based oxygenation tool can include a circuitry housing unit, a light emitting diode (LED) box disposed on the circuitry housing unit, a plurality of LEDs disposed in the LED box, a diffuser sheet or lens disposed on the LED box, a lens holder disposed on the circuitry housing unit and configured to be movable with respect to the circuitry housing unit, a near-infrared (NIR) filter disposed on the lens holder, and a cellphone disposed on the circuitry housing unit and having an NIR sensitive camera. Each of the plurality of LEDs can have different wavelengths, and application software of the cellphone can be configured to acquire data from the NIR sensitive camera and process the data before storing the data.

Abstract: A method for managing application launching in an electronic device is provided. The method includes identifying a plurality of user interaction parameters and a plurality of hardware parameters of the electronic device, identifying, based on the plurality of user interaction parameters and the plurality of hardware parameters, an optimal time to pre-launch an application in a background, identifying at least one next probable application to be launched, pre-launching the at least one next probable application in the background at the optimal time, detecting at least one event to launch the at least one second application in the foreground, and launching the at least one second application in the foreground based on a user input.

Abstract: Accordingly the embodiments herein provide a method for managing scheduling of services during a boot-up process in an electronic device including a multi-core processor. The method includes determining a plurality of services initiated during the boot-up process of the electronic device. Further, the method includes registering system parameters associated with the electronic device for each one of the determined services. Further, the method includes determining whether the service is critical or non-critical for the boot-up process. Further, the method includes tagging a label data to each one of the determined services, wherein the label data represents whether the service is critical or non-critical. Further, the method includes clustering each of the services into one of an accelerating cluster and a decelerating cluster based on the registered system parameters associated with the electronic device and the tagged label data.

Abstract: A system comprises a trolley for travel along an aisle of an aircraft interior. An infrared sensor is mounted on the trolley, a controller is operatively connected to the infrared sensor, and an output device is operatively connected to the controller. The controller includes machine readable instructions configured to cause the controller to receive input from the infrared sensor and to issue an alert to the output device upon detection of an obstacle in the input from the infrared sensor.

Abstract: Disclosed is a method for boosting (e.g., improving) graphics performance of an electronic device. The method for boosting graphics performance of an electronic device comprises: determining a context of the electronic device for boosting the graphics performance, determining a current state of the electronic device, determining at least one graphics configuration of hardware components of the electronic device and at least one application of the electronic device based on the context of the electronic device and the current state of the electronic device and generating a virtual display for displaying the at least one application based on the at least one graphics configuration of the hardware components and the at least one application.

Abstract: This invention relates to kits including novel oral food challenge meal formulations. In particular, the invention also relates to kits including novel oral food challenge meal formulations, wherein the placebo dose formulation is indistinguishable from non-placebo dose formulations.

Abstract: The present invention is related to topical ophthalmic compositions comprising one or more active components. The active components in the topical ophthalmic compositions include, but are not limited to carbachol, phospholine iodide and pharmaceutically acceptable salts thereof. Also described herein are methods for the treatment of presbyopia, methods for improving near vision in a subject with presbyopia, and methods for reducing pupil diameter in a subject with presbyopia using the topical ophthalmic compositions.

Abstract: An explainable artificially intelligent (XAI) application contains an ordered sequence of artificially intelligent software modules. When an input dataset is submitted to the application, each module generates an output dataset and an explanation that represents, as a set of Boolean expressions, reasoning by which each output element was chosen. If any pair of explanations are determined to be semantically inconsistent, and if this determination is confirmed by further determining that an apparent inconsistency was not a correct response to an unexpected characteristic of the input dataset, nonzero inconsistency scores are assigned to inconsistent elements of the pair of explanations.