Abstract: The invention provides a compound of formula (I), or salt thereof, wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; for use in a method of enhancing or improving fertility in a male or female subject, for example, a human male subject. The invention also provides a method of enhancing or improving fertility in a subject (for example a male subject) comprising administering a compound of formula (I) to the subject, and compositions that find use in such methods.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media that provides customized editing access rights for sub-portions of a digital design document. In particular, the disclosed systems generate a mapping between a selected sub-portion of a plurality of sub-portions of a digital design document and a user account indicating editing access rights to the selected sub-portion for the user account. Furthermore, the disclosed systems receives digital content from a client device associated with the user account for the selected sub-portion. Moreover, the disclosed systems modify the selected sub-portion to include the digital content from the client device based on the mapping between the selected sub-portion and the user account.

Abstract: In various examples, detecting occluded objects within images or other sensor data representations for autonomous or semi-autonomous systems and applications is described herein. Systems and methods described herein may determine when objects are occluded at portions of images using various techniques. For example, an image may be processed in order to determine classifications associated with objects depicted by the image and, the classifications, along with labels that are projected on the image using a map, may then be used to determine whether one or more of the objects are occluded in the image. For another example, a map may be used to determine first distances to points within an environment and a point cloud may be used to determine second distances to the points within the environment. The distances may then be used to determine whether one or more objects are occluded within the image.

Abstract: A plurality of data interactions are monitored and a plurality of potential exceptions relating to the data interactions are identified. Each potential exceptions is analyzed based on a respective pre-configured logic to determine a result relating to the potential exception. A plurality of data objects are generated, wherein each data object includes one or more of the potential exceptions, the results determined for the potential exceptions and other related data. The data objects are passed as nodes of a tangle associated with a tangle network. A federated machine learning (ML) model is deployed with each node passed to the tangle to determine whether the results are correct. A report is generated including a plurality of potential exceptions determined as valid.

Abstract: Embodiments predict errors using database validation rules. Validation rules can be defined that include business logic for validating transactions performed on a database with a data model. Transactions can be performed using the database, where the database is in a post-transaction state after performance of the transactions. The database can be validated in the post-transaction state by performing the defined business logic for a subset of validation rules, where at least one validation rule fails to validate. Using a trained machine learning model, one or more errors for one or more future transactions can be predicted, the predicted errors being based on the at least one failed validation rule.

Abstract: In various examples, data mining using group classifiers for autonomous and semi-autonomous systems and applications is described. For instance, systems and methods may train and use a classifier that is configured to determine whether data samples (e.g., images) represent objects associated with a group in various training and/or mining iterations. For instance, after each iteration, the classifier may become more accurate such that the classifier is able to better identify first data samples that are associated with the group (e.g., positive images) and/or second data samples that are not associated with the group (e.g., negative images). Additionally, the systems and methods may use another classifier to determine classifications associated with objects represented by at least the first data samples that are associated with the group. The systems and method may then store these first data samples and the classifications in one or more databases.

Abstract: Disclosed are aqueous formulations comprising urolithins particularly water-based formulations comprising urolithins and maltodextrin. Also disclosed are compositions for admixture with water, methods for the preparation of such aqueous formulations, and to the uses of such formulations for both the treatment of diseases, disorders and conditions, for example, diseases disorders or conditions characterized by inadequate mitochondrial function and for administration to generally healthy individuals for example, for improving health and improving muscle function and performance.

Abstract: Embodiments described herein facilitate text wrapping around a text-based glyph in an effective and efficient manner. In embodiments, a text-based glyph is generated within a document. The glyph is generated from a font file that includes glyph data that instruct a document editor how to generate the glyph. Using the glyph data, an intersection between the glyph and a text tile, e.g., a text area boundary where text can be placed, of the document. An insertion location based on intersection is identified, and text is inserted within the text tile at the insertion location, thus providing the effect of wrapping the text around the text-based glyph.

Abstract: Embodiments predict errors using database validation rules. Validation rules can be defined that include business logic for validating transactions performed on a database with a data model. Transactions can be performed using the database, where the database is in a post-transaction state after performance of the transactions. The database can be validated in the post-transaction state by performing the defined business logic for a subset of validation rules, where at least one validation rule fails to validate. Using a trained machine learning model, one or more errors for one or more future transactions can be predicted, the predicted errors being based on the at least one failed validation rule.

Abstract: The invention provides methods useful for treating post-viral illness, including long COVID-19, in a subject afflicted therewith comprising administering to the subject an urolithin.

Abstract: Methods and systems for content distribution and management are presented. A transaction flow for conducting different stages of a transaction is determined in response to a request for the transaction from an application executable at a user device. The transaction flow includes a sequence of content pages to be displayed within a graphical user interface (GUI) of the application over the different stages of the transaction. The content associated with a tagged UI element of at least one content page is identified. The content is validated for the tagged UI element of the at least one content page, based on a software and hardware configuration of the user device. The validated content is provided via a network to the application at the user device to be displayable with the tagged UI element on the at least one content page of the transaction flow during a corresponding stage of the transaction.

Abstract: Disclosed are compounds for use in raising an immune response to an antigen and/or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

Abstract: Process control of continuous production of biomolecules is a major challenge due to complex nature of processes and time scales of operations involved. Availability of key process variables in real-time is one of main requirements. This disclosure relates to a processor implemented method of controlling a continuous bioprocessing plant which includes at least one of: receiving, an input data associated with one or more equipments; generating, by a recipe builder, a sequence of unit operations to determine at least one job order based on the at least input data; obtaining, a control decision associated with a control parameter based on the at least one job order; communicating, via the middleware, the control decision associated with the control parameter to the PLC; and executing, by a control system of the PLC, the control decision on a unit equipment to control: (i) a continuous bioprocessing train, and (ii) an individual unit operation.

Abstract: Methods and systems for content distribution and management are presented. A transaction flow for conducting different stages of a transaction is determined in response to a request for the transaction from an application executable at a user device. The transaction flow includes a sequence of content pages to be displayed within a graphical user interface (GUI) of the application over the different stages of the transaction. The content associated with a tagged UI element of at least one content page is identified. The content is validated for the tagged UI element of the at least one content page, based on a software and hardware configuration of the user device. The validated content is provided via a network to the application at the user device to be displayable with the tagged UI element on the at least one content page of the transaction flow during a corresponding stage of the transaction.

Abstract: The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prophylaxis of a condition, disease or disorder in a subject, wherein the compound or salt is orally administered to a subject in a daily amount of from 2.8 to 6.6 mmol per day, over a period of at least 21 days. Also are provided are the compound of formula (I) for use in increasing mitophagy and/or autophagy, maintaining and/or improving muscle function and administration as a dietary, nutritional and/or health supplement.

Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).

Abstract: Present disclosure discloses a simple litz planar architecture using minimal vias for reducing Alternating Current (AC) resistance. The simple litz planar structure comprises a plurality of conductor strands of a first layer, a plurality of conductor strands of a second layer; and a plurality of vias set. The first layer and the second layer are separated by an insulating layer and each vias set is configured to perform transposition between a corresponding conductor strand of the first layer and a conductor strand of the second layer. The disclosed transposition method is simple, easy to manufacture and consequently, cost effective. The reduction in AC resistance obtained using disclosed simple litz planar structure is similar to planar litz winding. Further reduction in AC resistance is obtained by implementing multi-transposition per layer in the disclosed simple litz winding structure.

Abstract: The present disclosure provides a system for utilization of an advertisement fraud data to blacklist or whitelist one or more entities. The system includes a first step of collecting the advertisement fraud data associated with online advertisement and commerce fraud. The system includes another step of creating a blacklist of one or more entities from the collected advertisement fraud data. The system includes another step of blocking the one or more entities present in the created blacklist in real-time. The system includes another step of generating a whitelist of one or more entities from the created blacklist of the one or more entities. The system includes yet another step of optimizing the blacklist of the one or more entities in real-time.

Abstract: A load control system may be configured using a graphical user interface software. The graphical user interface software may display a first icon and a second icon. The first icon may represent a first electrical device and the second icon may represent a second electrical device. The first icon and the second icon may represent the relative location of the first electrical device and the second electrical device within a load control environment. The graphical user interface software may display a line from a selected icon (e.g., first icon) to a cursor. The graphical user interface software may adjust the line from the selected icon, for example, as the cursor moves. The graphical user interface software may define and store an association between the first electrical device and a second electrical device, for example, in response to the user selecting the first icon and the second icon.

Abstract: Disclosed are compositions, particularly topical compositions comprising a urolithin, cosmetic compositions comprising a urolithin and cosmetic compositions comprising a urolithin and trehalose, compositions comprising urolithin and niacinamide (nicotinamide) and compositions comprising urolithin, trehalose, niacinamide and caffeine. Furthermore, the invention relates to urolithin for use in improving skin barrier function, for example, maintaining skin hydration, improving skin elasticity and firmness, and/or increasing or maintaining skin layer thickness.