Abstract: The invention provides a compound of formula (I) wherein: A, B, C, D, W, X, Y and Z are each independently selected from H and OH; or a salt thereof; for use in the treatment and/or prophylaxis of a condition, disease or disorder in a subject, wherein the compound or salt is orally administered to a subject in a daily amount of from 2.8 to 6.6 mmol per day, over a period of at least 21 days. Also are provided are the compound of formula (I) for use in increasing mitophagy and/or autophagy, maintaining and/or improving muscle function and administration as a dietary, nutritional and/or health supplement.

Abstract: Methods and systems for facilitating photo-based estimation are described. In an aspect, a server is configured to send via a communications module to a remote computing device a first signal comprising a chat interface. The server may receive, via the communications module and from the remote computing device, a second signal representing input received at the remote computing device through the chat interface. The server may identify an account associated with the remote computing device and retrieve policy data associated with the identified account from the data store. The server may automatically evaluate the input and policy data against predetermined criteria to determine whether a claim has a low risk level and, when the claim is determined to have a low risk level, engage a photo-based estimation module.

Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).

Abstract: Present disclosure discloses a simple litz planar architecture using minimal vias for reducing Alternating Current (AC) resistance. The simple litz planar structure comprises a plurality of conductor strands of a first layer, a plurality of conductor strands of a second layer; and a plurality of vias set. The first layer and the second layer are separated by an insulating layer and each vias set is configured to perform transposition between a corresponding conductor strand of the first layer and a conductor strand of the second layer. The disclosed transposition method is simple, easy to manufacture and consequently, cost effective. The reduction in AC resistance obtained using disclosed simple litz planar structure is similar to planar litz winding. Further reduction in AC resistance is obtained by implementing multi-transposition per layer in the disclosed simple litz winding structure.

Abstract: The present disclosure provides a system for utilization of an advertisement fraud data to blacklist or whitelist one or more entities. The system includes a first step of collecting the advertisement fraud data associated with online advertisement and commerce fraud. The system includes another step of creating a blacklist of one or more entities from the collected advertisement fraud data. The system includes another step of blocking the one or more entities present in the created blacklist in real-time. The system includes another step of generating a whitelist of one or more entities from the created blacklist of the one or more entities. The system includes yet another step of optimizing the blacklist of the one or more entities in real-time.

Abstract: A load control system may be configured using a graphical user interface software. The graphical user interface software may display a first icon and a second icon. The first icon may represent a first electrical device and the second icon may represent a second electrical device. The first icon and the second icon may represent the relative location of the first electrical device and the second electrical device within a load control environment. The graphical user interface software may display a line from a selected icon (e.g., first icon) to a cursor. The graphical user interface software may adjust the line from the selected icon, for example, as the cursor moves. The graphical user interface software may define and store an association between the first electrical device and a second electrical device, for example, in response to the user selecting the first icon and the second icon.

Abstract: Disclosed are compositions, particularly topical compositions comprising a urolithin, cosmetic compositions comprising a urolithin and cosmetic compositions comprising a urolithin and trehalose, compositions comprising urolithin and niacinamide (nicotinamide) and compositions comprising urolithin, trehalose, niacinamide and caffeine. Furthermore, the invention relates to urolithin for use in improving skin barrier function, for example, maintaining skin hydration, improving skin elasticity and firmness, and/or increasing or maintaining skin layer thickness.

Abstract: Digital content design system techniques are described using baseline units to control arrangement and sizing of digital content. In one example, a digital content design system receives a user input specifying a number of baselines to be included within an available display area of a page. Baselines are used to align digital content to control arrangement of the digital content within the page, e.g., text. From this, the digital content design system then calculates a baseline unit from a distance used to space adjacent baselines of the number of baselines from each other. This baseline unit is then leveraged by the system as a fundamental unit of measure to control arrangement and/or sizing of digital content in relation to each other.

Abstract: Disclosed are improved methods for the treatment of diseases, disorders and conditions, such as cancer, using cell populations treated with a urolithin or urolithins, specifically urolithin-treated T-cell populations, for example, by enhancing the immune response comprising enhancement of antigen presentation and/or through enhancement of the expansion of T memory stem cells. Furthermore, disclosed are methods for overcoming or reversal of T-cell dysfunction to help treat diseases, such as cancer. More specifically, for example, disclosed are methods for overcoming of T-cell exhaustion. Also disclosed are cell populations enriched in T-memory stem cells.

Abstract: A load control system may be configured using a graphical user interface software. The graphical user interface software may display a first icon and a second icon. The first icon may represent a first electrical device and the second icon may represent a second electrical device. The first icon and the second icon may represent the relative location of the first electrical device and the second electrical device within a load control environment. The graphical user interface software may display a line from a selected icon (e.g., first icon) to a cursor. The graphical user interface software may adjust the line from the selected icon, for example, as the cursor moves. The graphical user interface software may define and store an association between the first electrical device and a second electrical device, for example, in response to the user selecting the first icon and the second icon.

Abstract: There are provided systems and methods for a secure identity verification marketplace using hashed data and forward hashing search functions. A service provider, such as an electronic transaction processor or other entity that may provide an online platform, may provide an online marketplace accessible by identity verification data bureaus, as well as entities requiring identity verification or other entities. The bureaus may utilize an SDK provided by the service provider to has their identity data and upload to the marketplace with metadata explaining the underlying identity verification data. This may be done so the underlying data is not revealed to the service provider or other entities without purchase and/or request to the bureau. When an entity searches for the data, a forward hashing function may determine hashes of different variations of the search query, which may be used to locate matching data.

Abstract: Embodiments predict errors using database validation rules. Validation rules can be defined that include business logic for validating transactions performed on a database with a data model. Transactions can be performed using the database, where the database is in a post-transaction state after performance of the transactions. The database can be validated in the post-transaction state by performing the defined business logic for a subset of validation rules, where at least one validation rule fails to validate. Using a trained machine learning model, one or more errors for one or more future transactions can be predicted, the predicted errors being based on the at least one failed validation rule.

Abstract: The present disclosure relates to a formulation including: a) a dendron of Formula I; b) at least one bio-therapeutic; c) at least one buffer; and d) at least one salt, wherein the bio-therapeutic to dendron molar ratio is in the range of 1:0.5-1:3. The dendron stabilizes the bio-therapeutic in the formulation at a temperature of up to 55° C.

Abstract: Disclosed are compounds for use in raising an immune response to an antigen and/or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

Abstract: The invention relates generally to a method and system that provides robust metric reporting based on analysis of computer vision derived-video data. The invention utilizes learning-based methods for object identification, object localization, and contextual analysis in order to generate insights into, for example, efficiency, productivity, design and planning, and health and safety compliance in a workflow environment.

Abstract: Process control of continuous production of biomolecules is a major challenge due to complex nature of processes and time scales of operations involved. Availability of key process variables in real-time is one of main requirements. This disclosure relates to a processor implemented method of controlling a continuous bioprocessing plant which includes at least one of: receiving, an input data associated with one or more equipments; generating, by a recipe builder, a sequence of unit operations to determine at least one job order based on the at least input data; obtaining, a control decision associated with a control parameter based on the at least one job order; communicating, via the middleware, the control decision associated with the control parameter to the PLC; and executing, by a control system of the PLC, the control decision on a unit equipment to control: (i) a continuous bioprocessing train, and (ii) an individual unit operation.

Abstract: Disclosed are compounds for use in raising an immune response to an antigen and/or enhancing, modulating or augmenting an immune response to an antigen. Particularly the use of urolithins. The invention also relates to immune enhancers comprising urolithins, methods of using such immune enhancers and processes for the preparation of such immune enhancers. The invention also relates to the use of urolithins in methods for modulating stem cell function, for example, enhancing stem cell numbers, promoting stem cell regeneration and promoting stem cell differentiation.

Abstract: The present invention relates to method of using spectroscopy for real time measuring of concentration of desired product and using measured data for monitoring and control of chromatography. It develops a method and system for measuring real-time concentration of clarified harvest and that of flow through of loading step of the chromatography and using measured data for determining breakthrough in real-time. The two modes of operation are used viz. first mode (Part A) uses a single near infrared spectroscopy (NIR) flow cell prior to the continuous chromatography column to ensure optimal loading in each cycle based on dynamic binding capacity studies carried out previously with the desired Protein A resin and second mode (Part B) uses two near infrared spectroscopy (NIR) flow cells, one before and one after the column, to detect the breakthrough curve (from 1% breakthrough onwards).

Abstract: The present disclosure provides a system for utilization of an advertisement fraud data to blacklist or whitelist one or more entities. The system includes a first step of collecting the advertisement fraud data associated with online advertisement and commerce fraud. The system includes another step of creating a blacklist of one or more entities from the collected advertisement fraud data. The system includes another step of blocking the one or more entities present in the created blacklist in real-time. The system includes another step of generating a whitelist of one or more entities from the created blacklist of the one or more entities. The system includes yet another step of optimizing the blacklist of the one or more entities in real-time.

Abstract: The present disclosure provides a method and system for creating decentralized repository of fraud IP and publishers using block chain. The block chain network creates a central repository for decentralized shared ledger. The block chain network adds a ledger in decentralized shared ledger for each interaction on an application. In addition, the block chain network authorizes at least one of a plurality of stakeholders to access the decentralized shared ledger after receiving a request from at least one of the plurality of stakeholders. Further, the block chain network analyzes the interaction and past data received from a plurality of stake holders. Furthermore, the block chain network blocks device IPs, device Id's, device type and the publishers mentioned in blacklist of the decentralized shared ledger.