Abstract: A head for dispensing a thin film of a fluid over a substrate is disclosed. The head includes a body assembly that extends between a first and a second end that is at least a width of the substrate. The body includes a main bore that is defined between the first and the second ends, the main bore connected to an upper side of a reservoir through a plurality of feeds that are defined between the main bore and the reservoir. The body also includes a plurality of outlets connected to a lower side of the reservoir and extends to an outlet slot. The plurality of feeds has a larger cross-sectional area than the plurality of outlets and the plurality of feeds are fewer than the plurality of outlets. The fluid is configured to flow through the main bore, through the plurality of feeds along the bore and fill the reservoir up to at least the threshold level before fluid is evenly output as a film out of the outlet slot onto the substrate.

Abstract: A system and method is disclosed to functionally show how to use a technology-based continuous quality improvement platform with software integration to improve the execution of complex processes in a measurable way. The platform demonstrates how healthcare delivery, as one example of a complex process, is represented as an input-output system (inputs represent determinants of outcomes, and outputs represent the impact those determinants have on specific measures). The software system helps execute tasks, monitors responses (i.e. outputs), learns (by correlating inputs to outputs), and adjusts (by providing practical decision support to users); ultimately these are the basic steps to create a technology based continuous quality improvement methodology for complex systems. Healthcare as one example of a complex input-output model: Inputs represent the ingredients and contextual factors of healthcare delivery that would have impact on metrics that are tracked (i.e.

Abstract: A system and method for managing tasks and workflow in a complex environment such as a healthcare unit are described. The architecture of the inventive system includes core components and peripheral components that interact with each primarily through an interfacing event framework application within the core system. In addition to the event framework, the core system comprises a collaborative task platform and an intelligence application. The peripheral components include input devices for users, a system applications server, an integration server, person and asset tracking tags, a database server, and a knowledge base. The system manages workflow through a task-based orientation, and making use of task-based process mapping. Tasks may be created, including unstructured tasks, tasks may further be monitored, shared, transferred, and completed. The process may be envisioned as circular feedback loop including task management, metrics tracking, and real time process feedback.

Abstract: This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment of pain or cough. The present invention further provides pharmaceutical compositions comprising codeine, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other analgesic and/or antitussive compounds.

Abstract: The present invention provides novel water soluble testosterone analogs. These testosterone analogs are suitable for intranasal administration to patients requiring increased plasma testosterone levels. The present invention also provides pharmaceutical compositions containing the testosterone analogs of the present invention. The present invention further provides a method of increasing plasma testosterone levels in patients in need of such treatment comprising the intranasal administration of the water-soluble testosterone analogs and pharmaceutical compositions of the present invention.

Abstract: The present invention is directed to a method for enhancing the delivery of delta-9-tetrahydrocannabinol (“THC”) to the brain of a mammal in need of treatment with this drug, by administering water-soluble prodrugs of THC intranasally.

Abstract: This invention provides a method of rapidly and reliably delivering folic acid, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment or prevention of Alzheimer's Disease and stroke. The present invention further provides intranasal pharmaceutical compositions comprising folic acid, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other anti-Alzheimer's or anti-stroke compounds.

Abstract: This invention provides a method of rapidly and reliably delivering sildenafil, or derivatives thereof, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route so as to produce virtually instantaneous onset of beneficial effects in the treatment of erectile dysfunction. The present invention further provides pharmaceutical compositions comprising sildenafil, or derivatives thereof, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without apomorphine.

Abstract: This invention provides to a method for enhancement of delivery of bupropion by administration via the nasal route, and methods of treatment comprising intranasal administration of bupropion. The present invention further provides pharmaceutical compositions comprising bupropion and/or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.

Abstract: The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.

Abstract: A kit and method of non-destructively radiolabelling a biomolecule substrate by halogenation, including the steps of: a) reacting a secondary amine with a chlorinating agent to produce an N-chloro secondary amine, (b) reacting the N-chloro secondary amine with a salt of a radiolabelled halogen to produce a radiolabelled halogenating agent, (c) reacting a solution of the biomolecule substrate with the radiolabelled halogenating agent, and (d) recovering a radiohalogenated biomolecule from the reaction of step (c). The kit and method allow for more complete iodination with a lessening of side reactions such as decomposition of the biomolecule substrate to be labelled.

Abstract: The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.

Abstract: The invention provides a novel method of administering narcotic antagonists, narcotic analgesics and related compounds, and novel dosage forms containing those compounds which are adapted for nasal administration. The nasal dosage forms disclosed include solutions, suspensions, gels and ointments. Especially preferred compounds which can be advantageously administered in accordance with the invention include naloxone, naltrexone, nalbuphine, levorphanol, buprenorphine, butorphanol, .DELTA..sup.9 -tetrahydrocannabinol (THC), cannabidiol (CBD) and levonantradol.

Abstract: The invention provides a novel method of administering selected known adrenergic .beta.-receptor blocking agents, such as dichloroisoproterenol, pronethalol, sotalol and alprenolol, which are of use in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further provides novel dosage forms of those .beta.-blockers which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

Abstract: The invention relates to a novel method of administering propranolol, a known .beta.-adrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further relates to novel dosage forms of propranolol which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

Abstract: The invention relates to a novel method of administering the natural female sex hormones, 17 .beta.-estradiol and progesterone, to achieve enhanced bioavailability thereof. The invention further relates to novel dosage forms of 17 .beta.-estradiol and/or progesterone which are adapted for nasal administration, such as solutions, suspensions, gels and ointments. The dosage forms containing a combination of 17 .beta.-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or synthetic female hormone.

Abstract: The invention relates to a novel method of administering the natural female sex hormones, 17 .beta.- estradiol and progesterone, to achieve enhanced bioavailability thereof. The invention further relates to novel dosage forms of 17 .beta.- estradiol and/or progesterone which are adapted for nasal administration, such as solutions, suspensions, gels and ointments. The dosage forms containing a combination of 17 .beta.-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or synthetic female hormone.

Abstract: The invention relates to a novel method of administering propranolol, a known .beta.-andrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further relates to novel dosage forms of propranolol which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

Abstract: There is provided a novel derivative of 2-acetoxybenzoic acid, i.e., 1-O-(2'-acetoxy)benzoyl-.alpha.-D-2-deoxyglucopyranose, which is suitable for the attainment of high 2-acetoxybenzoic acid blood levels without irritation of the gastrointestinal lining.