Patents by Inventor Anwar A. Hussain
Anwar A. Hussain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4241055Abstract: There are provided novel derivatives of 2-acetoxybenzoic acid, which are substituted 1-0-(2'acetoxy)benzoyl-.alpha.-D-2-deoxyglucopyranose derivatives and are suitable for the attainment of high 2-acetoxybenzoic acid blood levels without irritation of the gastrointestinal lining.Type: GrantFiled: May 30, 1979Date of Patent: December 23, 1980Assignee: The University of Kentucky Research FoundationInventors: Anwar A. Hussain, James E. Truelove, Harry B. Kostenbauder
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Patent number: 4188951Abstract: An intrauterine system for releasing beneficial agent to the uterus at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the uterus. The system contains a beneficial agent and it is formed of a copolymeric material permeable to the passage of agent by diffusion. The material is an ethylene-vinyl ester polymer of the general formula: ##STR1## wherein R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100-m)% by weight.Type: GrantFiled: August 22, 1977Date of Patent: February 19, 1980Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar A. Hussain
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Patent number: 4144317Abstract: Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.Type: GrantFiled: September 21, 1977Date of Patent: March 13, 1979Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 4120958Abstract: There is provided, a novel 2-acetoxybenzoic acid-nicotinamide complex, which exhibits enhanced water solubility and dissolution characteristics, thus permitting rapid absorption of the 2-acetoxybenzoic acid through the gastrointestinal lining for attainment of exceptional 2-acetoxybenzoic acid blood levels.Type: GrantFiled: March 11, 1977Date of Patent: October 17, 1978Assignee: Interx Research CorporationInventor: Anwar A. Hussain
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Patent number: 4069307Abstract: Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.Type: GrantFiled: May 30, 1975Date of Patent: January 17, 1978Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 4065566Abstract: There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein R represents a hydrogen atom, an acyl group, a ##STR2## group, a --CO-pyridyl group, and a --CO--R.sub.3 group, wherein R.sub.3 represents the residue of any N,N-C.sub.1 -C.sub.2 dialkylamino acid or a C.sub.4 -C.sub.6 cycloalkylamino acid ##STR3## wherein R.sub.1 represents a member selected from the group consisting of a hydroxyl group and a --OM group, wherein M is an alkali metal (Na, K, etc.) or an ammonium ion; and wherein R.sub.2 represents a member selected from the group consisting of a ##STR4## group, a --CO-pyridyl group, and a --CO--R.sub.3 group, wherein R.sub.3 represents the residue of any N,N-(C.sub.1 -C.sub.2)-dialkylamino acid or a C.sub.4 -C.sub.6 -cycloalkylamino acid ##STR5## wherein R represents an acyl group; wherein R.sub.2 represents a hydrogen atom; and wherein R.sub.1 represents a --NHCH(R.sub.4)COOR.sub.5 group, wherein R.sub.Type: GrantFiled: September 7, 1976Date of Patent: December 27, 1977Assignee: INTERx Research CorporationInventors: Nicolae S. Bodor, Kenneth B. Sloan, Anwar A. Hussain
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Patent number: 4057619Abstract: An ocular therapeutic system for releasing a drug to the eye at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the eye. The system contains an ophthalmically acceptable drug and it is formed of a polymeric material permeable to the passage of drug by diffusion. The material is an ethylene-vinyl ester copolymer of the general formula: ##STR1## WHEREIN R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100 - m)% by weight.Type: GrantFiled: July 15, 1976Date of Patent: November 8, 1977Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 4052505Abstract: Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.Type: GrantFiled: July 15, 1976Date of Patent: October 4, 1977Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 4035507Abstract: There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein R represents a hydrogen atom, an acyl group, ##STR2## group, a -CO-pyridyl group, and a -CO-R.sub.3 group, wherein R.sub.3 represents the residue of any N,N-C.sub.1 -C.sub.2 dialkylamino acid or a C.sub.4 -C.sub.6 cycloalkylamino acid (e.g., ##STR3## wherein R.sub.1 represents a member selected from the group consisting of a hydroxyl group and a --OM group, wherein M is an alkali metal (Na, K, etc.) or an ammonium ion; and wherein R.sub.2 represents a member selected from the group consisting of a ##STR4## group, a -CO-pyridyl group, and a --CO-R.sub.3 group, wherein R.sub.3 represents the residue of any N,N-(C.sub.1 -C.sub.2)--dialkylamino acid or a C.sub.4 -C.sub.6 -cycloalkylamino acid (e.g., ##STR5## wherein R represents an acyl group; wherein R.sub.2 represents a hydrogen atom; and wherein R.sub.1 represents a --NHCH(R.sub.4)COOR.sub.5 group, wherein R.sub.Type: GrantFiled: July 23, 1976Date of Patent: July 12, 1977Assignee: Interx Research CorporationInventors: Nicolae S. Bodor, Kenneth B. Sloan, Anwar A. Hussain
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Patent number: 4016251Abstract: Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.Type: GrantFiled: May 30, 1975Date of Patent: April 5, 1977Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 3998799Abstract: There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##STR1## wherein n represents an integer of from 2 to 50 with respect to formula (V-A), and wherein n represents an integer of from 1 to 50 with respect to formula (V-B);R represents a hydrogen atom, an acyl group, ##STR2## --CO-pyridyl, or --CO--R.sub.3, wherein R.sub.3 is the residue of any N,N-C.sub.1 -C.sub.2 dialkylamino acid or a C.sub.4 -C.sub.6 cycloalkylamino acid; R.sub.1 represents --OH, --O-lower alkyl, --O-benzyl, or a naturally occurring protein amino acid; and R.sub.2 represents ##STR3## --CO-pyridyl, a naturally occurring protein amino acid, 3',4'-L-diacyloxy phenylalanine, or --CO-R.sub.3.These compounds are all useful in the treatment of Parkinson's Disease.Type: GrantFiled: April 17, 1975Date of Patent: December 21, 1976Assignee: Interx Research CorporationInventors: Nicolae S. Bodor, Kenneth B. Sloan, Anwar A. Hussain
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Patent number: 3995632Abstract: An osmotic dispenser is described which is capable of releasing to its outside environment concentrations of active agent at an osmotically controlled rate over a prolonged period of time, and the active agent formulation of which is a solid or semisolid at storage temperatures, advantageously room temperature, and is fluid at the temperature of the prospective situs for the osmotic dispenser, typically at body temperature.Type: GrantFiled: September 30, 1974Date of Patent: December 7, 1976Assignee: Alza CorporationInventors: Masahiro Nakano, Takeru Higuchi, Anwar Hussain
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Patent number: 3995635Abstract: A drug-dispensing ocular insert containing a drug and suited for application to the eyeball to dispense said drug to the eye over a prolonged period of time, includes, for permitting facile insertion into and comfortable retention within the eye, and more importantly for preventing the accidental expulsion of the insert therefrom, first detent means adapted for insertion into the cul-de-sac of the conjunctiva between the sclera of the eyeball and the upper eyelid, and second, conjoint detent means, cooperative with said first detent means, adapted for insertion into the cul-de-sac of the conjunctiva between the said sclera of the eyeball and the lower eyelid.Type: GrantFiled: November 4, 1974Date of Patent: December 7, 1976Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar A. Hussain, John W. Shell
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Patent number: 3993071Abstract: An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of the eye concurrently with the dispensing or at a point in time after the dispensing of the therapeutically desired amount of drug.Type: GrantFiled: July 24, 1975Date of Patent: November 23, 1976Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar A. Hussain, John W. Shell
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Patent number: 3986510Abstract: An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of the eye concurrently with the dispensing or at a point in time after the dispensing of the therapeutically desired amount of drug.Type: GrantFiled: August 1, 1975Date of Patent: October 19, 1976Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar A. Hussain, John W. Shell
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Patent number: 3981303Abstract: An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of the eye concurrently with the dispensing or at a point in time after the dispensing of the therapeutically desired amount of drug.Type: GrantFiled: July 31, 1975Date of Patent: September 21, 1976Assignee: Alza CorporationInventors: Takeru Higuchi, Anwar A. Hussain, John W. Shell
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Patent number: 3960150Abstract: An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time. The device meters the flow of drug by means of a drug release rate controlling material. The insert bioerodes in the environment of the eye concurrently with the dispensing or at a point in time after the dispensing of the therapeutically desired amount of drug.Type: GrantFiled: September 15, 1975Date of Patent: June 1, 1976Assignee: Alza CorporationInventors: Anwar A. Hussain, Takeru Higuchi, John W. Shell
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Patent number: 3956490Abstract: Alkaline earth metal salts of salicylamide are administered in solid oral dosage forms with substantially improved analgesic, anti-inflammatory, antipyretic and sedative results as compared with salicylamide. Highest blood levels are obtained by administering enteric-coated salicylamide salt dosage forms.Type: GrantFiled: March 11, 1975Date of Patent: May 11, 1976Assignee: Interx Research CorporationInventors: Takeru Higuchi, Anwar A. Hussain
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Patent number: 3950521Abstract: Alkali and alkaline earth metal salts of salicylamide are administered in solid oral dosage forms with substantially improved analgesic, anti-inflammatory, antipyretic and sedative results as compared with salicylamide. Highest blood levels are obtained by administering enteric-coated salicylamide salt dosage forms.Type: GrantFiled: May 23, 1975Date of Patent: April 13, 1976Assignee: Interx Research CorporationInventors: Takeru Higuchi, Anwar Hussain
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Patent number: 3939253Abstract: There is provided, novel, transient pro-drug forms of L-DOPA (3,4-dihydroxy-L-phenylalanine), having the formula: ##SPC1##Wherein R represents a member selected from the group consisting of a hydrogen atom, a --COCH.sub.3 group, a --COC.sub.2 H.sub.5 group, a --COOC.sub.2 H.sub.5 group, and a --CO--C(CH.sub.3).sub.3 group; wherein R.sub.1 represents a member selected from the group consisting of a hydroxyl group, a --OM group (wherein M represents an alkali metal or an ammonium ion), a --OCH.sub.2 --C.sub.6 H.sub.5 group, a --OCH.sub.3 group, a --OC.sub.2 H.sub.5 group, and --NH--CH(R.sub.3)COOH group, wherein R.sub.3 represents the residue of any naturally occurring amino acid; and wherein R.sub.2 represents a member selected from the group consisting of a hydrogen atom, a formyl group, a --CO--C.sub.6 H.sub.5 group, a --CO--pyridyl group, a --CO(R.sub.5)--CH=CH(R.sub.4) group, and a NH.sub.2 --CH(R.sub.6)--CO-- group, wherein R.sub.4 represents a methyl group and wherein R.sub.Type: GrantFiled: April 10, 1975Date of Patent: February 17, 1976Assignee: Interx Research CorporationInventors: Nicolae S. Bodor, Kenneth B. Sloan, Anwar A. Hussain