Abstract: Methods and systems are presented for classifying a digital image of a document using a machine learning model framework. The machine learning model framework is configured to provide a classification output based on a fusion of features corresponding to different modalities and extracted from the digital image. The machine learning model framework includes multiple encoders. Each encoder is configured to encode features corresponding to a distinct modality into a respective embedding. Different embeddings generated by the multiple encoders are fused together using one or more fusion techniques. The fused embedding is provided to a machine learning model for classifying the document.

Abstract: Disclosed herein are compounds of formula (I), and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt or solvate thereof; and therapeutic uses of these compounds, which are inhibitors of SHP2, potentially useful in the treatment of SHP2-associated diseases, such as SHP2-associated cancers.

Abstract: A display substrate and a method of manufacturing the display substrate are provided. The display substrate includes a base substrate and a plurality of sub-pixels. A first electrode of a light-emitting element of the sub-pixel includes: a first conductive layer electrically connected to a source or a drain of a driving transistor of the sub-pixel; a second conductive layer; and a transparent material layer. The transparent material layer includes a first transparent material sub-layer and a second transparent material sub-layer, the first transparent material sub-layer is between the second transparent material sub-layer and the second conductive layer, the second transparent material sub-layer covers the first transparent material sub-layer, and an edge of the first transparent material sub-layer is aligned with an edge of the second conductive layer.

Abstract: A vehicle includes a system performing a method of controlling an operation of the vehicle during a tire blowout. The system includes a vehicle dynamics sensor for detecting a dynamic parameter of the vehicle, tire sensors for detecting wheel speeds of wheels of the vehicle, and a processor. The processor is configured to receive a velocity of the vehicle from the vehicle dynamics sensor and the wheel speeds from the tire sensors, determine a diagonal product ratio of the wheel speeds, compare the diagonal product ratio to a range to detect an occurrence of a tire blowout, identify a location of the tire blowout from a wheel speed ratio based on wheels that are diagonally opposite each other, and control the operation of the vehicle in response to the tire blowout.

Abstract: The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Abstract: The present application relates to an anti-tumor compound and use thereof, specifically, the present application relates to a ligand conjugate or a tautomer, a mesomer, a racemate, an enantiomer and a diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. The present application further relates to a method for preparing the ligand conjugate and the use thereof.

Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: A method for processing a blockchain transaction using a payment card and a linked blockchain wallet includes: receiving an authorization request for a payment transaction initiated using the payment card, wherein the authorization request includes transaction data, the transaction data including at least a payment card number, a transaction amount, and a destination address; identifying the linked blockchain wallet based on an association between the linked blockchain wallet and the payment card number; verifying compliance with one or more restrictions on use of the linked blockchain wallet based on at least the transaction data and a transaction history of the linked blockchain wallet; and executing a smart contract stored on a blockchain of a blockchain network associated with the linked blockchain wallet, where at least the transaction amount and destination address are provided as input for the smart contract.

Abstract: A display substrate and a method of manufacturing the display substrate are provided. The display substrate includes a base substrate and a plurality of sub-pixels (Pxl). A first electrode of a light-emitting element of the sub-pixel (Pxl) includes: a first conductive layer electrically connected to a source (S) or a drain (D) of a driving transistor of the sub-pixel (Pxl); a second conductive layer; and a transparent material layer. The transparent material layer includes a first transparent material sub-layer and a second transparent material sub-layer, the first transparent material sub-layer is between the second transparent material sub-layer and the second conductive layer, the second transparent material sub-layer covers the first transparent material sub-layer, and an edge of the first transparent material sub-layer is aligned with an edge of the second conductive layer.

Abstract: A virtual reality neuropsychological assessment (VRNA) system uses a deep learning network and a VR headset to administer multi-domain assessments of human cognitive performance. The deep learning network is trained to identify features in sensor data indicative of neuropsychological performance and classify users based on the features identified in the sensor data. The VR headset provides a user with a virtual simulation of an activity involving decision-making scenarios. During the virtual simulation, sensor data via a plurality of sensors of the VR headset is captured. The sensor data is applied to the deep learning network to identify features of the user and classify the user based on the features into a neuropsychological domains, such as attention, memory, processing speed, and executive function. Sensor data includes eye-tracking, hand-eye motor coordination, reaction time, working memory, learning and delayed memory, and inhibitory control.

Abstract: Provided is a beam-column joint of a prefabricated self-centering RC (Reinforced Concrete) frame based on an SMA (Shape Memory Alloy) material, including an RC precast column, an RC precast beam, and self-centering energy dissipation dampers arranged, and a friction energy dissipation damper. The self-centering energy dissipation damper includes an SMA kernel, an upper restraint cover plate, a lower restraint cover plate, a column-end connection reinforcing plate and a beam-end connection reinforcing plate, and a set energy dissipation gap is reserved between the SMA kernel and the upper restraint cover plate. The friction energy dissipation damper includes an in-column embedded connecting plate and a beam-end embedded connecting plate.

Abstract: The present invention provides a prodrug compound, a preparation method, and the use thereof. In particular, the present invention provides a compound as represented by formula (I), a preparation method, and the use thereof as a prodrug for preparing topical formulations.

Abstract: The present invention provides a toxin molecule suitable for an antibody drug conjugate. In particular, the present invention provides a compound represented by formula (I) below or a pharmaceutically acceptable salt or hydrate thereof. The compound of the present invention can be used in the preparation of a pharmaceutical composition for treating diseases associated with tumor cell proliferation.

Abstract: The present disclosure relates to the field of environment monitoring equipment, and in particular, to a device for determining threshold wind speed in intermittent wind-sand flow. The device includes a base. A rotary bearing is installed on the base. A circuitry is installed in the base. A telescopic rod is installed through the rotary bearing. A wind driven vane and an earth surface wind-sand monitoring frame are installed on the telescopic rod. Photoelectric induction probes are installed on the earth surface wind-sand monitoring frame.

Abstract: The present invention provides a new wideband mm-wave end-fire magneto-electric dipole antenna with excellent beam-scanning radiation patterns and reasonably low side lobes and low cross polarizations. The antenna comprises: an asymmetrical substrate integrated coaxial line feed comprising: a first substrate having a first substrate thickness; a second substrate placed on the first substrate and having a second substrate thickness different from the first substrate thickness; a conductive signal line deposited on an upper surface of the first substrate; and two rows of waveguiding vias positioned along and at both sides of the signal line respectively; a ?-shaped probe adopted to excite the antenna; a pair of shorted planar parallel plates serving as magnetic dipole and two pair of vertical conductive vias serving as electric dipole; and a folded vertical reflector consisting of conductive vias and strips is added to reduce the back radiation and to improve the gain of antenna.

Abstract: An air distribution mechanism and a corresponding cryogenic refrigerator are provided. The air distribution mechanism includes an air distribution valve (6) and a rotary valve (7), the air distribution valve (6) includes an air distribution valve main body (6a) and an air distribution valve seat (6b), an air distribution plane (6a3) that is on the air distribution valve main body (6a) and faces away from the air distribution valve seat (6b) protrudes relative to the air distribution valve seat (6b), the air distribution plane (6a3) is tightly attached to a switching plane (73) on the rotary valve (7), and the switching plane (73) protrudes from the rotary valve (7); the air distribution valve (6) is fixedly mounted in a mounting chamber of a cover (2), and the rotary valve (7) is rotatable around a principal rotation axis O of the rotary valve relative to the air distribution valve (6) to switch connection states of an air distribution side flow path and a switching side flow path.

Abstract: A self-pressure-relief air distribution mechanism includes an air distribution valve (6) where a rear face of the air distribution valve (6) is divided into a high-pressure face (66) and a low-pressure face (65), each hermetically separated by a third sealing ring (b3) that seals the air distribution valve (6) and a cover (2). A low-pressure passage (22) of the cover (2) can communicate with the rear face of the air distribution valve (6) via a pressure-relief hole (61), to guide a low-pressure airflow in the cover (2) to the rear face of the air distribution valve (6). A cryogenic refrigerator includes the self-pressure-relief air distribution mechanism. With the provision of the pressure-relief hole (61) and the third sealing ring (b3), the self-pressure-relief air distribution mechanism has a reduced pressure receiving area, thereby reducing a positive acting force and reducing wear.

Abstract: Disclosed are a cold storage material and a cold storage type cryogenic refrigerator using same. The cold storage material is tin alloy particles, the content of tin in the tin alloy particle is not less than 40% and not more than 99%, and the cold storage material at least includes one component of bismuth, antimony, silver and gold. The cold storage type cryogenic refrigerator includes a cold storage device, and the cold storage material filled in the cold storage device is tin alloy particles, is lead-free, lowly toxic, easy in spherization and extremely accessible and has a relatively good thermal performance, has properties comparable to those of lead, and has a relatively good heat exchange performance when being used in a cold storage type refrigerator.

Abstract: An immersion dual-cycle multi-mode liquid cooling regulation system and method for a data center comprises data center cabinets, a microchannel condensation heat exchanger, a plate heat exchanger, waste heat recovery devices, a cooling water storage tank, a fluorinated liquid storage tank, a liquid pump, a fluorinated liquid, pipelines, and pipeline valves. The system switches between single-phase and two-phase circulation loops according to the working power consumption of a server and the thermophysical property of a cooling working medium, and realizes flexible adjustment and control according to the cooling demand of the cabinet, the load magnitude and the working environment, thus avoiding the waste of resources caused by different loads in the data center; and cooling water flows through the waste heat recovery devices to recover heat, to reduce the electricity consumption of the system and greatly improve the utilization efficiency of cooling capacity.

Abstract: The present disclosure relates to the field of environment monitoring equipment, and in particular, to a device for determining threshold wind speed in intermittent wind-sand flow. The device includes a base. A rotary bearing is installed on the base. A case group is installed in the base. A telescopic rod is installed through the rotary bearing. A wind driven beacon and an earth surface wind sand monitoring frame are installed on the telescopic rod. Photoelectric induction probes are installed on the earth surface wind sand monitoring frame.