Abstract: Methods and systems are presented for classifying a digital image of a document using a machine learning model framework. The machine learning model framework is configured to provide a classification output based on a fusion of features corresponding to different modalities and extracted from the digital image. The machine learning model framework includes multiple encoders. Each encoder is configured to encode features corresponding to a distinct modality into a respective embedding. Different embeddings generated by the multiple encoders are fused together using one or more fusion techniques. The fused embedding is provided to a machine learning model for classifying the document.

Abstract: Disclosed herein are compounds of Formula I, and/or stereoisomers, stable isotopes, or pharmaceutically acceptable salts or solvates thereof; and therapeutic uses of these compounds, which are inhibitors of rearranged during transfection (RET) and potentially useful in the treatment of RET-associated diseases, such as RET-associated cancers.

Abstract: Disclosed herein is a method for treating a cancer in a subject in need thereof, comprising identifying the cancer to be a BRCA mutation cancer or a BRCA wild type cancer having a homologous recombination deficiency; and administering to the subject a therapeutically effective amount of an Aurora A inhibitor, or a pharmaceutically acceptable salt, hydrate, solvate, amorphous solid, or polymorph thereof.

Abstract: The present disclosure relates to an antibody-drug conjugate and the use thereof. Specifically, provided is an antibody-drug conjugate as represented by formula I, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, Ab-(L-D)a formula I.

Abstract: The present application provides a toxin molecule suitable for an antibody-drug conjugate. In particular, the present application provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt or hydrate thereof. The compound of the present application can be used in the preparation of a pharmaceutical composition for treating diseases associated with tumor cell proliferation.

Abstract: A vehicle includes a system performing a method of controlling an operation of the vehicle during a tire blowout. The system includes a vehicle dynamics sensor for detecting a dynamic parameter of the vehicle, tire sensors for detecting wheel speeds of wheels of the vehicle, and a processor. The processor is configured to receive a velocity of the vehicle from the vehicle dynamics sensor and the wheel speeds from the tire sensors, determine a diagonal product ratio of the wheel speeds, compare the diagonal product ratio to a range to detect an occurrence of a tire blowout, identify a location of the tire blowout from a wheel speed ratio based on wheels that are diagonally opposite each other, and control the operation of the vehicle in response to the tire blowout.

Abstract: A preparation method and an application of an interpenetrating solid electrolyte interface are provided. According to the present disclosure, a lithium metal electrode plate is prepared into a lithium oxide plating layer in an air atmosphere, and then a lithium sulfide plating layer is prepared by soaking in a lithium polysulfide plating solution, and then a lithium sulfide/lithium oxide interpenetrating solid electrolyte interface is obtained by drying at normal temperature.

Abstract: The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.

Abstract: Systems and methods detect cortical arousal events from a single time-varying ECG signal that is obtained via single-lead ECG. A pre-trained deep neural network transforms the ECG signal into a sequence of cortical-arousal probabilities. The deep neural network includes an inception module, a residual neural network, and a long short-term memory neural network to identify structure in the ECG signal that distinguishes periods of cortical arousal from periods without cortical arousal.

Abstract: A soft decoding method, an electronic device, and a storage medium. The soft decoding method includes: performing a hard read on a storage device and performing a hard decoding based on a read data of the hard read; determining, in response to the hard decoding being failed, a soft-decoding reference data based on the read data of the hard read; and performing a soft decoding based on soft-decoding reference data.

Abstract: Methods and systems are presented for classifying a digital image of a document using a machine learning model framework. The machine learning model framework is configured to provide a classification output based on a fusion of features corresponding to different modalities and extracted from the digital image. The machine learning model framework includes multiple encoders. Each encoder is configured to encode features corresponding to a distinct modality into a respective embedding. Different embeddings generated by the multiple encoders are fused together using one or more fusion techniques. The fused embedding is provided to a machine learning model for classifying the document.

Abstract: Disclosed herein are compounds of formula (I), and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt or solvate thereof; and therapeutic uses of these compounds, which are inhibitors of SHP2, potentially useful in the treatment of SHP2-associated diseases, such as SHP2-associated cancers.

Abstract: A display substrate and a method of manufacturing the display substrate are provided. The display substrate includes a base substrate and a plurality of sub-pixels. A first electrode of a light-emitting element of the sub-pixel includes: a first conductive layer electrically connected to a source or a drain of a driving transistor of the sub-pixel; a second conductive layer; and a transparent material layer. The transparent material layer includes a first transparent material sub-layer and a second transparent material sub-layer, the first transparent material sub-layer is between the second transparent material sub-layer and the second conductive layer, the second transparent material sub-layer covers the first transparent material sub-layer, and an edge of the first transparent material sub-layer is aligned with an edge of the second conductive layer.

Abstract: A vehicle includes a system performing a method of controlling an operation of the vehicle during a tire blowout. The system includes a vehicle dynamics sensor for detecting a dynamic parameter of the vehicle, tire sensors for detecting wheel speeds of wheels of the vehicle, and a processor. The processor is configured to receive a velocity of the vehicle from the vehicle dynamics sensor and the wheel speeds from the tire sensors, determine a diagonal product ratio of the wheel speeds, compare the diagonal product ratio to a range to detect an occurrence of a tire blowout, identify a location of the tire blowout from a wheel speed ratio based on wheels that are diagonally opposite each other, and control the operation of the vehicle in response to the tire blowout.

Abstract: The present disclosure provides a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds. They are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers. Also disclosed herein is a pharmaceutical composition, comprising a compound of Formula (I) and/or a stereoisomer, a tautomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Abstract: The present application relates to an anti-tumor compound and use thereof, specifically, the present application relates to a ligand conjugate or a tautomer, a mesomer, a racemate, an enantiomer and a diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. The present application further relates to a method for preparing the ligand conjugate and the use thereof.

Abstract: A method for processing a blockchain transaction using a payment card and a linked blockchain wallet includes: receiving an authorization request for a payment transaction initiated using the payment card, wherein the authorization request includes transaction data, the transaction data including at least a payment card number, a transaction amount, and a destination address; identifying the linked blockchain wallet based on an association between the linked blockchain wallet and the payment card number; verifying compliance with one or more restrictions on use of the linked blockchain wallet based on at least the transaction data and a transaction history of the linked blockchain wallet; and executing a smart contract stored on a blockchain of a blockchain network associated with the linked blockchain wallet, where at least the transaction amount and destination address are provided as input for the smart contract.

Abstract: A display substrate and a method of manufacturing the display substrate are provided. The display substrate includes a base substrate and a plurality of sub-pixels (Pxl). A first electrode of a light-emitting element of the sub-pixel (Pxl) includes: a first conductive layer electrically connected to a source (S) or a drain (D) of a driving transistor of the sub-pixel (Pxl); a second conductive layer; and a transparent material layer. The transparent material layer includes a first transparent material sub-layer and a second transparent material sub-layer, the first transparent material sub-layer is between the second transparent material sub-layer and the second conductive layer, the second transparent material sub-layer covers the first transparent material sub-layer, and an edge of the first transparent material sub-layer is aligned with an edge of the second conductive layer.

Abstract: A virtual reality neuropsychological assessment (VRNA) system uses a deep learning network and a VR headset to administer multi-domain assessments of human cognitive performance. The deep learning network is trained to identify features in sensor data indicative of neuropsychological performance and classify users based on the features identified in the sensor data. The VR headset provides a user with a virtual simulation of an activity involving decision-making scenarios. During the virtual simulation, sensor data via a plurality of sensors of the VR headset is captured. The sensor data is applied to the deep learning network to identify features of the user and classify the user based on the features into a neuropsychological domains, such as attention, memory, processing speed, and executive function. Sensor data includes eye-tracking, hand-eye motor coordination, reaction time, working memory, learning and delayed memory, and inhibitory control.

Abstract: The present invention provides a prodrug compound, a preparation method, and the use thereof. In particular, the present invention provides a compound as represented by formula (I), a preparation method, and the use thereof as a prodrug for preparing topical formulations.