Abstract: The present disclosure provides an earphone including a sound production component, an ear hook, and a microphone assembly. The microphone assembly includes a first microphone and a second microphone. The sound production component or ear hook includes a first sound hole and a second sound hole corresponding to the first microphone and second microphone, respectively. An extension line of a line connecting a projection of the first sound hole on a sagittal plane of the user and a projection of the second sound hole on the sagittal plane has an intersection point with a projection of an antihelix, a ratio of a first distance between the projection of the first sound hole on the sagittal plane and the projection of the second acoustic hole on the sagittal plane to a second distance between the projection of the second acoustic hole on the sagittal plane and the intersection point is 1.8-4.4.

Abstract: Disclosed is an open earphone, comprising a sound production component and an ear hook. The ear hook may include a first portion and a second portion connected in sequence. The first portion may be hung between the auricle of a user and the head of the user, the second portion may extend toward a front outer side of the auricle and connect the sound production component, and the sound production component may be located close to the ear canal but not block the opening of the ear canal; wherein the sound production component and the auricle may have a first projection and a second projection on a sagittal plane, respectively, a centroid of the first projection may have a first distance from a highest point of the second projection in a vertical axis direction, a ratio of the first distance to a height of the second projection in the vertical axis direction may be within a range of 0.25-0.

Abstract: The present disclosure relates to an open earphone. The open earphone may include a sound production device and an ear hook including a first part and a second part connected in sequence. The first part may be hooked and arranged between an auricle and a head of a user. The second part may extend to a front lateral surface of the auricle and may be connected to the sound production device. The sound production device may be worn at a position that is near an ear canal without blocking an earhole of the user. The sound production device may be at least partially inserted into an auricular concha cavity of the user. An overlap ratio of a projection area of the sound production device on a sagittal plane to a projection area of the auricular concha cavity on the sagittal plane may be not less than 44.01%.

Abstract: A method may include: a first terminal device receiving a first identifier from a core network element, where the first identifier is used to modify a security protection policy of a terminal device; in a process in which the first terminal device establishes a connection to a second terminal device for a service, the first terminal device determines, based on the first identifier, whether to enable security protection for the connection; and the first terminal device sends first information to the second terminal device, where the first information indicates whether to enable security protection for the connection.

Abstract: An air distribution mechanism and a corresponding cryogenic refrigerator are provided. The air distribution mechanism includes an air distribution valve (6) and a rotary valve (7), the air distribution valve (6) includes an air distribution valve main body (6a) and an air distribution valve seat (6b), an air distribution plane (6a3) that is on the air distribution valve main body (6a) and faces away from the air distribution valve seat (6b) protrudes relative to the air distribution valve seat (6b), the air distribution plane (6a3) is tightly attached to a switching plane (73) on the rotary valve (7), and the switching plane (73) protrudes from the rotary valve (7); the air distribution valve (6) is fixedly mounted in a mounting chamber of a cover (2), and the rotary valve (7) is rotatable around a principal rotation axis O of the rotary valve relative to the air distribution valve (6) to switch connection states of an air distribution side flow path and a switching side flow path.

Abstract: Disclosed is an open earphone, comprising a sound production component and an ear hook. The ear hook may include a first portion and a second portion connected in sequence. The first portion may be hung between the auricle of a user and the head of the user, the second portion may extend toward a front outer side of the auricle and connect the sound production component, and the sound production component may be located close to the ear canal but not block the opening of the ear canal; wherein the sound production component and the auricle may have a first projection and a second projection on a sagittal plane, respectively, a centroid of the first projection may have a first distance from a highest point of the second projection in a vertical axis direction, a ratio of the first distance to a height of the second projection in the vertical axis direction may be within a range of 0.25-0.

Abstract: A modified nucleoside or nucleotide, the 3?-OH of the modified nucleoside or nucleotide being reversibly blocked; meanwhile, the present invention also relates to a kit comprising the nucleoside or nucleotide, and a sequencing method based on the nucleoside or nucleotide.

Abstract: A self-pressure-relief air distribution mechanism includes an air distribution valve (6) where a rear face of the air distribution valve (6) is divided into a high-pressure face (66) and a low-pressure face (65), each hermetically separated by a third sealing ring (b3) that seals the air distribution valve (6) and a cover (2). A low-pressure passage (22) of the cover (2) can communicate with the rear face of the air distribution valve (6) via a pressure-relief hole (61), to guide a low-pressure airflow in the cover (2) to the rear face of the air distribution valve (6). A cryogenic refrigerator includes the self-pressure-relief air distribution mechanism. With the provision of the pressure-relief hole (61) and the third sealing ring (b3), the self-pressure-relief air distribution mechanism has a reduced pressure receiving area, thereby reducing a positive acting force and reducing wear.

Abstract: Disclosed are a cold storage material and a cold storage type cryogenic refrigerator using same. The cold storage material is tin alloy particles, the content of tin in the tin alloy particle is not less than 40% and not more than 99%, and the cold storage material at least includes one component of bismuth, antimony, silver and gold. The cold storage type cryogenic refrigerator includes a cold storage device, and the cold storage material filled in the cold storage device is tin alloy particles, is lead-free, lowly toxic, easy in spherization and extremely accessible and has a relatively good thermal performance, has properties comparable to those of lead, and has a relatively good heat exchange performance when being used in a cold storage type refrigerator.

Abstract: An immersion dual-cycle multi-mode liquid cooling regulation system and method for a data center comprises data center cabinets, a microchannel condensation heat exchanger, a plate heat exchanger, waste heat recovery devices, a cooling water storage tank, a fluorinated liquid storage tank, a liquid pump, a fluorinated liquid, pipelines, and pipeline valves. The system switches between single-phase and two-phase circulation loops according to the working power consumption of a server and the thermophysical property of a cooling working medium, and realizes flexible adjustment and control according to the cooling demand of the cabinet, the load magnitude and the working environment, thus avoiding the waste of resources caused by different loads in the data center; and cooling water flows through the waste heat recovery devices to recover heat, to reduce the electricity consumption of the system and greatly improve the utilization efficiency of cooling capacity.

Abstract: The present disclosure relates to the field of environment monitoring equipment, and in particular, to a device for determining threshold wind speed in intermittent wind-sand flow. The device includes a base. A rotary bearing is installed on the base. A case group is installed in the base. A telescopic rod is installed through the rotary bearing. A wind driven beacon and an earth surface wind sand monitoring frame are installed on the telescopic rod. Photoelectric induction probes are installed on the earth surface wind sand monitoring frame.

Abstract: The present invention provides a JAK kinase inhibitor and a preparation and application thereof, and the present invention specifically provides a compound having a structure represented in the following formula I, an enantiomer thereof, or a pharmaceutically acceptable salt thereof. The compound has uniquely advantageous JAK kinase inhibitory activity, and as such may be used for treatment of a disease or illness related to JAK kinase activity or expression level.

Abstract: The present invention provides a new wideband mm-wave end-fire magneto-electric dipole antenna with excellent beam-scanning radiation patterns and reasonably low side lobes and low cross polarizations. The antenna comprises: an asymmetrical substrate integrated coaxial line feed comprising: a first substrate having a first substrate thickness; a second substrate placed on the first substrate and having a second substrate thickness different from the first substrate thickness; a conductive signal line deposited on an upper surface of the first substrate; and two rows of waveguiding vias positioned along and at both sides of the signal line respectively; a ?-shaped probe adopted to excite the antenna; a pair of shorted planar parallel plates serving as magnetic dipole and two pair of vertical conductive vias serving as electric dipole; and a folded vertical reflector consisting of conductive vias and strips is added to reduce the back radiation and to improve the gain of antenna.

Abstract: Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers.

Abstract: Provided are a tricyclic compound as shown in formula (I) as a CRTH2 inhibitor, or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a solvate thereof, and the use thereof in treating diseases related to CRTH2 receptors.

Abstract: Provided is a novel PDGFR kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. Further provided are use and a method of the compound of formula (I) for preventing or treating conditions associated with PDGFR kinase activity, particularly use and a method for preventing or treating conditions associated with PDGFR? and/or PDGFR? kinase activity.

Abstract: (I) Disclosed herein are compounds of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt or solvate thereof; and therapeutic uses of these compounds, which are inhibitors of rearranged during transfection (RET), potentially useful in the treatment of RET-associated diseases, such as RET-associated cancers.

Abstract: The present invention provides a novel pan-RAF kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof. The present invention also provides a use or method of the compound of formula (I) in the treatment or prevention of a disorder related to the activity of RAF and/or RAS kinase.

Abstract: In some examples, special-purpose machines are provided that facilitate smart copy optimization in a network service or publication system, including software-configured computerized variants of such special-purpose machines and improvements to such variants, and to the technologies by which such special-purpose machines become improved compared to other special-purpose machines that facilitate adding the new features. Such technologies can include special artificial-intelligence (AI), machine-learning (ML), and natural-language-processing (NLP) techniques.

Abstract: In some examples, special-purpose machines are provided that facilitate smart copy optimization in a network service or publication system, including software-configured computerized variants of such special-purpose machines and improvements to such variants, and to the technologies by which such special-purpose machines become improved compared to other special-purpose machines that facilitate adding the new features. Such technologies can include special artificial-intelligence (AI), machine-learning (ML), and natural-language-processing (NLP) techniques.