Patents by Inventor Aquilur Rahman
Aquilur Rahman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050019387Abstract: The present invention is for novel compositions and methods for treating cancer, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include liposome entrapped irinotecan in which the liposome can contain any of a variety of neutral or charged liposome-forming compounds and cardiolipin. The liposomes of the present invention can be either multilamellar vesicles and unilamellar vesicles, as desired.Type: ApplicationFiled: November 19, 2003Publication date: January 27, 2005Applicant: NeoPharm, Inc.Inventors: Aquilur Rahman, Imran Ahmad
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Publication number: 20040115714Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast cancer and lung cancer.Type: ApplicationFiled: October 6, 2003Publication date: June 17, 2004Applicants: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Constantinos Broustas, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20040106571Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-3 such as breast cancer and lung cancer.Type: ApplicationFiled: October 6, 2003Publication date: June 3, 2004Applicants: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Howard Boudreau, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20030229040Abstract: The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.Type: ApplicationFiled: January 21, 2003Publication date: December 11, 2003Applicant: GEORGETOWN UNIVERSITYInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20030228317Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-1 such as breast cancer and lung cancer.Type: ApplicationFiled: May 22, 2003Publication date: December 11, 2003Inventors: Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman, Imran Ahmad, Usha Kasid
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Publication number: 20030219476Abstract: This invention pertains to liposomal formulations of mitoxantrone and methods for their manufacture and use. The compositions of the present invention include liposomal formulations of mitoxantrone in which the liposome contains any of a variety of neutral or charged liposome-forming materials in addition to a compound that is thought to bind mitoxantrone, such as cardiolipin. The liposomal compositions can be used advantageously in conjunction with secondary therapeutic agents other than mitoxantrone, including antineoplastic, antifungal, antibiotic among other active agents. Methods are provided in which a therapeutically effective amount of the formulation is administered to a mammal, such as a human.Type: ApplicationFiled: April 14, 2003Publication date: November 27, 2003Applicant: NeoPharm, Inc.Inventors: Imran Ahmad, Aquilur Rahman
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Publication number: 20030215489Abstract: The invention relates to the use of oliognucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to chemosensitize cancer are tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treatment of ras expressing tumors such as breast, lung, pancreatic and prostate cancer.Type: ApplicationFiled: February 15, 2002Publication date: November 20, 2003Applicant: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Jin Pei, Rajshree Mewani, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20030215492Abstract: The present invention is for novel compositions and methods for treating diseases caused by cellular proliferation, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include SN-38 lipid complexes in which the complexes can contain any of a variety of neutral or charged lipids and, desirably, cardiolipin. The compositions are capable of efficiently incorporating SN-38 into complexes and are capable of solubilizing relatively high concentrations of SN-38.Type: ApplicationFiled: April 28, 2003Publication date: November 20, 2003Applicant: NeoPharm, Inc.Inventors: Imran Ahmad, Jia-Ai Zhang, Aquilur Rahman
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Publication number: 20030035830Abstract: Liposomal-encapsulated taxane or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer. The liposomal encapsulated paclitaxel allows for administration to a patient, particularly a human patient, in less than one hour without substantial toxicity.Type: ApplicationFiled: October 7, 2002Publication date: February 20, 2003Applicant: NEOPHARM, INC.Inventor: Aquilur Rahman
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Publication number: 20020160038Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5′-GTGCTCCATTGATGC-3′ (seq. #1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: ApplicationFiled: August 16, 2001Publication date: October 31, 2002Applicant: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 6461637Abstract: Liposomal-encapsulated taxane or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer. The liposomal encapsulated paclitaxel allows for administration to a patient in less than one hour.Type: GrantFiled: September 1, 2000Date of Patent: October 8, 2002Assignee: NeoPharm, Inc.Inventor: Aquilur Rahman
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Patent number: 6333314Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5′-GTGCTCCATTGATGC-3′ (seq. ID No. 1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: GrantFiled: January 13, 2000Date of Patent: December 25, 2001Assignee: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 6146659Abstract: Liposomal-encapsulated taxane or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer. The liposomal encapsulated paclitaxel allows for administration to a patient in less than one hour.Type: GrantFiled: July 1, 1998Date of Patent: November 14, 2000Assignee: Neopharm, Inc.Inventor: Aquilur Rahman
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Patent number: 6126965Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. #1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: GrantFiled: October 24, 1997Date of Patent: October 3, 2000Assignee: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 5665710Abstract: A liposome, which contains an oligodeoxynucleotide or an analog thereof.Type: GrantFiled: December 10, 1993Date of Patent: September 9, 1997Assignee: Georgetown UniversityInventors: Aquilur Rahman, Alain Thierry, Anatoly Dritschilo
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Patent number: 5648090Abstract: Liposomal-encapsulated taxol or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer, and which may be used advantageously in combination with hyperthermia. The liposomes confer enhanced stability and solubility to taxol or derivatives thereof.Type: GrantFiled: May 26, 1995Date of Patent: July 15, 1997Assignee: Georgetown UniversityInventors: Aquilur Rahman, Rafael Rafaeloff, Syed Rafat Husain
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Patent number: 5560923Abstract: A method of preparing a liposomal anthracycline glycoside composition, which entails forming cardiolipin-containing liposomes by drying a lipid mixture containing cardiolipin, and then introducing an aqueous solution, and mixing the cardiolipin-containing liposomes with a solution of anthracycline glycoside.Type: GrantFiled: September 28, 1994Date of Patent: October 1, 1996Assignee: Georgetown UniversityInventors: Aquilur Rahman, Alain Thierry, Anatoly Dritschilo
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Patent number: 5424073Abstract: Liposomal-encapsulated taxol or an antineoplastic derivative thereof or a mixture thereof is provided which is used to effect a therapeutically enhanced method of treating cancer, and which may be used advantageously in combination with hyperthermia. The liposomes confer enhanced stability and solubility to taxol or derivatives thereof.Type: GrantFiled: October 14, 1993Date of Patent: June 13, 1995Assignee: Georgetown UniversityInventors: Aquilur Rahman, Rafael Rafaeloff, Syed R. Husain
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Patent number: 4952408Abstract: A composition made up of a liposome-encapsulated vinca alkaloid is disclosed. This composition possesses an increased antitumor activity and a substantially lower toxicity as compared to free drug.Type: GrantFiled: May 23, 1988Date of Patent: August 28, 1990Assignee: Georgetown UniversityInventor: Aquilur Rahman
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Patent number: 4419348Abstract: Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.Type: GrantFiled: April 27, 1981Date of Patent: December 6, 1983Assignee: Georgetown UniversityInventors: Aquilur Rahman, Philip S. Schein