Abstract: An in vivo imaging device may include a capsule shaped housing and an image sensor. The capsule shaped housing may have a longitudinal axis and a window. The image sensor (e.g., a CMOS sensor) may include a pixel array portion and a circuitry portion. The circuitry portion may be segregated, for example longitudinally, from the pixel array portion. The pixel array portion may be disposed within said housing substantially parallel to said longitudinal axis. A light deflecting element disposed at an angle smaller than 45 degrees with respect to the pixel array portion introduces image distortion which is compensated by a distortion compensation mechanism.

Abstract: A device, system and method may enable the obtaining of in vivo images from within body lumens or cavities, such as images the gastrointestinal (GI) tract, where the data such as image data is typically transmitted or otherwise sent to a receiving system in compressed or diluted form. The image may be reconstructed and for example displayed to a user.

Abstract: An in vivo device, such as an in vivo imaging device or other sensing device, may include a device body and at least one appendage coupled to the device body. According to some embodiments the appendage(s) may be extended or expanded, or reduced or removed, in vivo, thereby altering the device geometry while in a body lumen.

Abstract: A moveable in vivo device comprises a device body and at least one moveable appendage that is moveably coupled the device body such that movement of the moveable appendage causes the device body to move in a body lumen.

Abstract: A device, system and method for motility measurement and analysis. For example, a system includes a processor to determine contractile activity within a body lumen based on an analysis of data received from an autonomous in-vivo device.

Abstract: A system and method for indicating transferability of a non-dissolvable target in-vivo device through the GI tract are described. The in vivo system includes a dissolvable in-vivo device which has two operational phases; an initial phase in which the device is of initial dimensions and a final phase in which the device is of final dimensions. In the initial phase the device can pass freely through a normally configured body lumen whereas it may not be able to pass freely through an abnormally configured lumen. In the final phase the device can pass freely through a body lumen even if it is abnormally configured.

Abstract: A device, system and method for motility measurement and analysis. For example, a system includes a processor to determine contractile activity within a body lumen based on an analysis of data received from an autonomous in-vivo device.

Abstract: A device and method for example operating an in vivo imaging device wherein the illumination is operated at a certain rate or range of rates, and images are transmitted from the device.

Abstract: An imager and a method for real-time, non-destructive monitoring of light incident on imager pixels during their exposure to light. Real-time or present pixel signals, which are indicative of present illumination on the pixels, are compared to a reference signal during the exposure. Adjustments, if necessary, are made to programmable parameters such as gain and/or exposure time to automatically control the imager's exposure to the light. In a preferred exemplary embodiment, only a selected number of pixels are monitored for exposure control as opposed to monitoring the entire pixel array.

Abstract: In some embodiments, an apparatus includes a substantially rigid base and a flexible substrate. The substantially rigid base has a first protrusion and a second protrusion, and is configured to be coupled to an electronic device. The flexible substrate has a first surface and a second surface, and includes an electrical circuit configured to electronically couple the electronic device to at least one of an electrode a battery, or an antenna. The flexible substrate is coupled to the base such that a first portion of the second surface is in contact with the first protrusion. A second portion of the second surface is non-parallel to the first portion.

Abstract: A device, system and method may enable the obtaining of in vivo images from within body lumens or cavities, such as images the gastrointestinal (GI) tract, where the data such as image data is typically transmitted or otherwise sent to a receiving system in compressed or diluted form. The image may be reconstructed and for example displayed to a user.

Abstract: In some embodiments, a method includes inserting at least a distal end portion of an insertion tool within a body. The distal end portion of the insertion tool is coupled to an electronic implant having a stimulation portion, a terminal portion and a substantially flexible conductor disposed between the stimulation portion and the terminal portion. The distal end portion of the insertion tool is moved within the body such that the stimulation portion of the electronic implant is disposed adjacent a target location and the terminal portion of the electronic implant is disposed beneath a skin of the body.

Abstract: A system and method for receiving an in vivo signal, using for example a receiver, a recorder and an antenna array. The receiver may include for example a switching unit and an amplifier, and may be in proximity to the antenna array.

Abstract: An in-vivo sensing device may include, for example, an in-vivo sensing module attached to a functional module. The in-vivo sensing module may include, for example, an in-vivo imager or sensor. The functional module may include, for example, a power source, a transmitter, or other components.

Abstract: In one embodiment, a method includes implanting an implant entirely under the subject's skin. The implant includes a passive electrical conductor of sufficient length to extend from subcutaneous tissue located below one of a surface cathodic electrode and a surface anodic electrode to the tibial nerve. The surface electrodes are positioned in spaced relationship on the subject's skin, with one of the electrodes positioned over the pick-up end of the electrical conductor such that the portion of the current is transmitted through the conductor to the tibial nerve, and such that the current flows through the tibial nerve and returns to the other of the surface cathodic electrode and the surface anodic electrode. An electrical current is applied between the surface cathodic electrode and the surface anodic electrode to cause the portion of the electrical current to flow through the implant to stimulate the tibial nerve.

Abstract: A device, system and method for capturing in-vivo images allows for size or distance estimations for objects within the images. A scale may be overlayed on or otherwise added to the images and, based on a comparison between the scale and an image of an object, the size of the object and/or the distance of the object from an imaging device may be estimated or calculated.

Abstract: A system and method for localizing an in vivo signal source using a wearable antenna array having at least two antenna elements. The signal is received and a signal strength is measured at two or more antenna elements. An estimated coordinate set is derived from the signal strength measurements.

Abstract: An imaging device having an in vivo CMOS image sensor, at least one illumination source and a controller. The controller controls the illumination source to illuminate for a first period and to be shut off for a subsequent period.

Abstract: An imager and a method for real-time, non-destructive monitoring of light incident on imager pixels during their exposure to light. Real-time or present pixel signals, which are indicative of present illumination on the pixels, are compared to a reference signal during the exposure. Adjustments, if necessary, are made to programmable parameters such as gain and/or exposure time to automatically control the imager's exposure to the light. In a preferred exemplary embodiment, only a selected number of pixels are monitored for exposure control as opposed to monitoring the entire pixel array.

Abstract: A system and method may determine the orientation of an in-vivo imaging device relative to the earth's gravitation field. Some embodiments may enable indication of specific locations where other methods provide non-satisfactory imaging coverage. The system may include an in-vivo imaging system with a container or shell containing an orientation object. The container may be placed in at least one optical dome or optical field of an in-vivo imaging device, such as an autonomous capsule. The location of the orientation object's image on the in-vivo imaging device imager, as well as size of the image, may be determined as functions of the location of the orientation object inside the container, for each image acquired.