Patents by Inventor Armin Heckel

Armin Heckel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Patent number: 7176231
    Abstract: The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: February 13, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Juergen Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
    Patent number: 7169936
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Grant
    Filed: July 22, 2003
    Date of Patent: January 30, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus C. A. Van Meel, Ulrike Tontsch-Grunt
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 7166615
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 23, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 7160901
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 9, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • INDOLINE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
    Publication number: 20070004757
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in Claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel, Ulrik Tontsch-Grunt
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Patent number: 7148249
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: December 12, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Juergen Roth, Thorsten Lehmann-Lintz, Ralf R. H. Lotz, Ulrike Tontsch-Grunt, Jacobus C. A. Van Meel
  • Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20060194813
    Abstract: The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: July 22, 2003
    Publication date: August 31, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Armin Heckel, Frank Hilberg, Thorsten Lehmann-Lintz, Guenter Linz, Joerg Kley, Jacobus Van Meel, Werner Rall, Gerald Roth, Peter Sieger, Ulrike Tontsch-Grunt
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060154939
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 13, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Nveed Chaudhary, Thorsten Lehmann-Lintz, Armin Heckel, Gerald Roth, Joerg Kley, Trixi Brandl, Georg Dahmann, Matthias Grauert
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060148883
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 6, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Nveed Chaudhary, Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060142373
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Gerald Roth, Armin Heckel, Nveed Chaudhary, Trixi Brandl, Georg Dahmann, Matthias Grauert
  • Indolinones and their use as antiproliferative agents
    Publication number: 20060135592
    Abstract: The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Darryl McConnell, Ulrike Weyer-Czernilofsky, Maria Impagnatiello, Steffen Steurer, Ralph Brueckner, Bernd Krist, Bodo Betzemeier, Frank Hilberg, Armin Heckel, Gerald Roth, Joerg Kley, Thorsten Lehmann-Lintz
  • Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050234120
    Abstract: The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050209302
    Abstract: The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Cycloalkyl - containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050203104
    Abstract: The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20050065346
    Abstract: The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 24, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Henning Priepke, Armin Heckel, Herbert Nar, Wolfgang Wienen, Jean Marie Stassen
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Publication number: 20050054710
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Roth, Thorsten Lehmann-Lintz, Ralf Lotz, Ulrike Tontsch-Grunt, Jacobus Van Meel
  • Indoline derivatives substituted in the 6 position, their preparation and their use as medicaments
    Publication number: 20050043389
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Application
    Filed: July 22, 2003
    Publication date: February 24, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel, Ulrike Tontsch-Grunt
  • Substituted indolinones
    Patent number: 6858641
    Abstract: The present invention relates to indolinones substituted in the 6-position of general formula wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: February 22, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel
  • Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
    Patent number: 6855710
    Abstract: The present invention relates to new substituted indolinones of general formula wherein X and R1 to R5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties. The above compounds of general formula I wherein R1 denotes a hydrogen atom, a C1-3-alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: February 15, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Wolfgang Grell, Armin Heckel, Frank Himmelsbach, Wolfgang Eberlein, Gerald Roth, Jacobus C.A. van Meel, Norbert Redemann, Walter Spevak, Ulrike Tontsch-Grunt, Thomas von Rueden
  • New substituted indolinones, their manufacture and their use as medicaments
    Publication number: 20050009898
    Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: July 27, 2004
    Publication date: January 13, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Roth, Armin Heckel, Rainer Walter, Ulrike Tontsch-Grunt, Walter Spevak, Jacobus Van Meel