Patents by Inventor Armin Heckel

Armin Heckel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted N-acylaniline derivatives, the preparation thereof, and their use as pharmaceutical compositions
    Publication number: 20040248897
    Abstract: Substituted N-acylaniline derivatives of general formula 1
    Type: Application
    Filed: December 22, 2003
    Publication date: December 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Henning Priepke, Norbert Hauel, Armin Heckel, Uwe Ries, Klaus Binder, Rainer Zimmermann, Jean-Marie Stassen, Wolfgang Wienen
  • Substituted piperazine derivatives, the preparation thereof and their use as medicaments
    Patent number: 6821967
    Abstract: The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc, Rf, Rg, X, m and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: November 23, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Thorsten Lehmann-Lintz, Armin Heckel, Leo Thomas, Michael Mark
  • Substituted piperazine derivatives, the preparation thereof and their use as medicaments
    Patent number: 6818644
    Abstract: The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, Rc Rf, Rg and m, n and X are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyseride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: November 16, 2004
    Assignee: Boehringer Ingelheim Pharm GmbH & Co, KG
    Inventors: Thorsten Lehmann-Lintz, Armin Heckel, Leo Thomas, Michael Mark
  • Use of Lck inhibitors for treatment of immunologic diseases
    Publication number: 20040204458
    Abstract: The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
    Type: Application
    Filed: August 14, 2003
    Publication date: October 14, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Rainer Walter, Frank Hilberg, Rudolf Hauptmann, Martin Friedrich Stefanic, Florian Colbatzky, Steffen Ernst
  • Substituted indolinones, their manufacture and their use as medicaments
    Patent number: 6794395
    Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically acceptable salts thereof which have valuable pharmacological properties, especially an inhibitory effect on various receptor-tyrosine kinases, and cycline/CDK complexes as well as on the proliferation of endothelial cells and various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: September 21, 2004
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Rainer Walter, Ulrike Tontsch-Grunt, Walter Spevak, Jacobus C. A. Van Meel
  • Substituted indolines which inhibit receptor tyrosine kinases
    Patent number: 6762180
    Abstract: Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: July 13, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Rainer Walter, Jacobus Van Meel, Norbert Redemann, Ulrike Tontsch-Grunt, Walter Spevak, Frank Hilberg
  • Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
    Publication number: 20040058978
    Abstract: The present invention relates to new substituted indolinones of general formula 1
    Type: Application
    Filed: September 19, 2003
    Publication date: March 25, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Wolfgang Grell, Armin Heckel, Frank Himmelsbach, Wolfgang Eberlein, Gerald Roth, Jacobus C. A. van Meel, Norbert Redemann, Walter Spevak, Ulrike Tontsch-Grunt, Thomas von Rueden
  • New substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040044222
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: August 22, 2003
    Publication date: March 4, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • New substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040044053
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: August 22, 2003
    Publication date: March 4, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 6638965
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumour cells, and inhibitors of protein kinases. The following compounds are exemplary: (Z)-3-{1-[4-(N-(2-aminoethyl)-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, (Z)-3-{1-[4-(N-(2-dimethylaminoethyl)-N-phenylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, and (Z)-3-{1-[4-(4-methylpiperazinomethyl)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: October 28, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Biphenyl derivatives, production thereof and uses as medicines
    Patent number: 6617325
    Abstract: The present invention relates to biphenyl derivatives of general formula wherein Ra to Rg and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: September 9, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Thorsten Lehmann-Lintz, Armin Heckel, Leo Thomas, Michael Mark
  • Substituted piperazine derivatives, the preparation thereofand their use as medicaments
    Publication number: 20030166637
    Abstract: The present invention relates to substituted piperazine derivatives of general formula 1
    Type: Application
    Filed: October 9, 2002
    Publication date: September 4, 2003
    Inventors: Thorsten Lehmann-Lintz, Armin Heckel, Leo Thomas, Michael Mark
  • Substituted piperazine derivatives as mtp inhibitors
    Publication number: 20030114442
    Abstract: The present invention relates to substituted piperazine derivatives of general formula 1
    Type: Application
    Filed: October 8, 2002
    Publication date: June 19, 2003
    Inventors: Armin Heckel, Thorsten Lehmann-Lintz, Leo Thomas, Michael Mark
  • Substituted indolinones
    Publication number: 20030092756
    Abstract: The present invention relates to indolinones substituted in the 6-position of general formula 1
    Type: Application
    Filed: April 4, 2002
    Publication date: May 15, 2003
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20030069299
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: November 1, 2001
    Publication date: April 10, 2003
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Substituted indolinones with kinase inhibitory activity
    Patent number: 6545035
    Abstract: Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are: 3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and 3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.
    Type: Grant
    Filed: October 3, 2001
    Date of Patent: April 8, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Armin Heckel, Rainer Walter, Wolfgang Grell, Jacobus C. A. Van Meel, Norbert Redemann
  • Substituted indolinones with kinase inhibitory activity
    Patent number: 6319918
    Abstract: Substituted indolinones of general formula having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. Exemplary compounds are: 3-Z-[1-(4-(N-Benzyl-N-methyl-aminomethyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone and 3-Z-[1-(4-(2,3,4,5-Tetrahydro-benzo(d)azepin-3-yl-methyl)-phenylamino)-1-methyl-methylene]-5-amido-2-indolinone.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: November 20, 2001
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Armin Heckel, Rainer Walter, Wolfgang Grell, Jacobus C. A. van Meel, Norbert Redemann
  • Antithrombotic phenylalkyl derivatives
    Patent number: 6300342
    Abstract: Antithrombotic phenylalkyl derivatives of the formula Exemplary compounds are: (a) 1-[3-(4-amidino-phenyl)propionyl]-6-(4-fluoro-phenylsulphonamido)-1,2,3,4-tetrahydro-quinoline, (b) 1-[3-(4-amidino-phenyl)propionyl]-6-butylsulphonamido-1,2,3,4-tetrahydro-quinoline, (c) 1-[3-(4-amidino-phenyl)propionyl]-5-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, (d) 1-[3-(4-amidino-phenyl)propionyl]-3-methyl-6-phenylsulphonamido-1,2,3,4-tetrahydro-quinoline, and, (e) 1-[3-(4-amidino-phenyl)propionyl]-6-(5-chloro-thien-2-ylsulphonamido)-1,2,3,4-tetrahydro-quinoline.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: October 9, 2001
    Assignee: Boehringer Ingelheim Pharm KG
    Inventors: Armin Heckel, Rainer Soyka, Wolfgang Grell, Eric Haaksma, Klaus Binder, Rainer Zimmerman
  • Indolinones having kinase inhibitory activity
    Patent number: 6169106
    Abstract: The present invention relates to substituted indolinones of general formula wherein R1 to R5, and X are defined as in claim 1, the isomers thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibitory effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these (compounds, their use and processes for preparing them.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: January 2, 2001
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Armin Heckel, Rainer Walter, Wolfgang Grell, Jacobus C. A. van Meel, Norbert Redemann
  • Indolinones having kinase-inhibiting activity
    Patent number: 6043254
    Abstract: The present invention relates to indolinones of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: March 28, 2000
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Wolfgang Grell, Helmut Wittneben, Jacobus Constantinus Antonius van Meel, Norbert Redemann, Rainer Walter, Armin Heckel, Frank Himmelsbach, Robert Haigh