Abstract: Fluid delivery devices for delivering therapeutic agents are described. More particularly, this disclosure relates to drug reconstitution devices having a plurality of components movable with respect to one another such that an active agent and a solvent can be reconstituted within the device prior to injection. The fluid delivery devices can include a housing, a cartridge holder, a cartridge disposed within the cartridge holder, a button rod, and a foot. The cartridge stores the active agent and the solvent, which are separated by one or more stoppers. The button rod and foot can provide an axial force upon the stopper(s) in the cartridge to inject the fluid once reconstituted. The foot and the button rod can be separate components, thereby enabling the foot to rotate independently with respect to the button rod as the cartridge holder is rotated to reconstitute the therapeutic and prime the device for injection.

Abstract: A compression device controller controls operation of a compression device to inflate at least one inflatable bladder to control forces applied to an arteriovenous fistula of a subject for maturing the arteriovenous fistula.

Abstract: A compression garment having a sealable bladder pocket adapted for applying compression therapy to a selected body part of a patient. The compression garment includes a selectively inflatable bladder and a wrap having a selectively sealable pocket. The pocket has a sealable main opening sized for passing the bladder therethrough for inserting the bladder in the pocket and removing the bladder from the pocket. A connector on the bladder may be connected to a fluid supply line via the main opening. In other embodiments, the connector may be connected in fluid communication with the fluid supply line via a secondary opening separated from the main opening. Fluid is delivered from the fluid source to an inflatable interior of the bladder to impart compression therapy to the body part.

Abstract: A catheter includes an outer tubular body, a spiral member, and a disruptor. The outer tubular body defines a longitudinal axis and extends to a distal annular cutting edge. The outer tubular body defines a lumen having distal and proximal ends. The spiral member is supported within the outer tubular body and includes proximal and distal ends. The distal end of the spiral member is positionable distally beyond the cutting edge of the outer tubular body. The disruptor is supported within the outer tubular body proximally of the cutting edge of the outer tubular body.

Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.

Abstract: A portable negative pressure wound therapy system includes a dressing assembly for positioning over a wound to apply a negative pressure to the wound and a canister assembly. The canister assembly includes a control unit having a vacuum source and a controller and a collection canister in communication with the dressing assembly operable to receive fluid from the wound. The collection canister has a filter assembly having a filter and a passageway between the filter and a wall of the collection canister. The collection canister also includes a canister interface having a suction port, an inlet port, and a channel. The vacuum source draws air through the suction port from the channel which draws air from the passageway connected to the channel, the air in the passageway is drawn from the collection canister through the filter, and the air in the collection canister is drawn through the inlet port.

Abstract: A method of controlling a compression device controls a vent phase of a compression device having an inflatable bladder capable of being pressurized for applying compression to a part of a subject's body. The method includes delivering pressurized fluid from a source of pressurized fluid to a first inflatable bladder disposed about a portion of the subject's body and venting the pressurized fluid from the first inflatable bladder by opening a first valve. The method further includes monitoring fluid pressure in the first inflatable bladder during the venting of the first inflatable bladder. Based at least in part on the monitored fluid pressure, the first valve is selectively closed and selectively reopened to control fluid pressure in the first inflatable bladder to remain within a desired residual pressure range.

Abstract: A method of controlling a compression device controls a vent phase of a compression device having an inflatable bladder capable of being pressurized for applying compression to a part of a subject's body. The method includes delivering pressurized fluid from a source of pressurized fluid to a first inflatable bladder disposed about a portion of the subject's body and venting the pressurized fluid from the first inflatable bladder by opening a first valve. The method further includes monitoring fluid pressure in the first inflatable bladder during the venting of the first inflatable bladder. Based at least in part on the monitored fluid pressure, the first valve is selectively closed and selectively reopened to control fluid pressure in the first inflatable bladder to remain within a desired residual pressure range.

Abstract: A method of controlling a compression device controls a vent phase of a compression device having an inflatable bladder capable of being pressurized for applying compression to a part of a subject's body. The method includes delivering pressurized fluid from a source of pressurized fluid to a first inflatable bladder disposed about a portion of the subject's body and venting the pressurized fluid from the first inflatable bladder by opening a first valve. The method further includes monitoring fluid pressure in the first inflatable bladder during the venting of the first inflatable bladder. Based at least in part on the monitored fluid pressure, the first valve is selectively closed and selectively reopened to control fluid pressure in the first inflatable bladder to remain within a desired residual pressure range.

Abstract: A compression garment having a sealable bladder pocket adapted for applying compression therapy to a selected body part of a patient. The compression garment includes a selectively inflatable bladder and a wrap having a selectively sealable pocket. The pocket has a sealable main opening sized for passing the bladder therethrough for inserting the bladder in the pocket and removing the bladder from the pocket. A connector on the bladder may be connected to a fluid supply line via the main opening. In other embodiments, the connector may be connected in fluid communication with the fluid supply line via a secondary opening separated from the main opening. Fluid is delivered from the fluid source to an inflatable interior of the bladder to impart compression therapy to the body part.

Abstract: An occlusion treatment device is disclosed that is configured and dimensioned for the treatment of a lumen that is at least partially blocked by an occlusion. The occlusion treatment device comprises a catheter including a body portion with proximal and distal ends, at least one expandable element that is secured to the body portion of the catheter, and a material removal element that extends distally from the distal end of the body portion including a debriding member in communication with an energy source to facilitate selective energizing of the debriding member. The catheter is axially movable through the lumen, and rotatable within the lumen, such that the material removal element selectively imparts non-mechanical and/or mechanical energy to the occlusion to effect debriding of the occlusion.

Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.

Abstract: A compression device for providing compression treatment to a limb of a wearer includes a compression garment positionable on the limb of the wearer. The garment includes an inflatable bladder for providing compression treatment to the limb. A controller is adapted for fluidly connecting to the inflatable bladder and configured for inflating and deflating the bladder during a compression cycle. The controller has an exhaust port positioned to direct exhaust fluid through the bladder so exhaust fluid flows over the limb of the wearer to cool the limb.

Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.

Abstract: A compression device controller controls operation of a compression device to inflate at least one inflatable bladder to control forces applied to an arteriovenous fistula of a subject for maturing the arteriovenous fistula.

Abstract: According to an embodiment of the present disclosure, a wound dressing system is presented. The wound dressing system includes a fluid permeable support layer, the support layer configured for positioning within a wound and adapted to generally conform to a topography of the wound, and to permit exudates from the wound to pass therethrough. The wound dressing system further includes a plurality of beads supported by the support layer, the beads defining an insulated inter-connected elongate member and an electrode embedded within and extending through at least a portion of the elongate member. Also, a current is generated by an external energy source that electrically flows through the electrode.

Abstract: A vascular compression system includes a compression garment and a controller for compressing a body part of a person. In some embodiments, the compression garment is a foot cuff or a leg sleeve. The controller inflates compression garment apparatus includes a compression garment and a pressurizer. The pressurizer has instructions for executing cyclic compression cycles for applying intermittent compression therapy to the body part. Each compression cycle includes an inflation phase and a vent phase. At least one of the inflation phases includes a pre-fill step and a therapeutic step. In the pre-fill step, gas pressure in the inflatable chamber may be increased at a reduced rate, and in the therapeutic step, the gas pressure in the inflatable chamber may be increased at a rapid rate.

Abstract: A tissue treatment apparatus for restoring patency in a body vessel is provided. The tissue treatment apparatus includes an elongated catheter dimensioned for insertion within a body vessel having an at least partial occlusion. Proximal and distal expandable segments are mounted to the elongated catheter and are positionable adjacent the occlusion and are configured to transition from a first condition to a second expanded condition. A mesh in operative engagement with the proximal and distal expandable segments is expandable radially outwardly from the catheter upon corresponding transition of the proximal and distal expandable segments to the second condition. The mesh includes a conductive material adapted to transmit electrosurgical energy to treat and facilitate removal of the occlusion, to thereby assist in restoring patency within the body vessel.

Abstract: According to an embodiment of the present disclosure, a wound dressing system is presented. The wound dressing system includes a fluid permeable support layer, the support layer configured for positioning within a wound and adapted to generally conform to a topography of the wound, and to permit exudates from the wound to pass therethrough. The wound dressing system further includes a plurality of beads supported by the support layer, the beads defining an insulated inter-connected elongate member and an electrode embedded within and extending through at least a portion of the elongate member. Also, a current is generated by an external energy source that electrically flows through the electrode.

Abstract: According to an embodiment of the present disclosure, a wound dressing system is presented. The wound dressing system includes a fluid permeable support layer, the support layer configured for positioning within a wound and adapted to generally conform to a topography of the wound, and to permit exudates from the wound to pass therethrough. The wound dressing system further includes a plurality of beads supported by the support layer, the beads defining an insulated inter-connected elongate member and an electrode embedded within and extending through at least a portion of the elongate member. Also, a current is generated by an external energy source that electrically flows through the electrode.