Patents by Inventor Arndt Rolfs

Arndt Rolfs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 11841362
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: December 12, 2023
    Assignee: Centogene GmbH
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the Diagnosis of Niemann-Pick Disease
    Publication number: 20220187283
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 16, 2022
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 11231412
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: January 25, 2022
    Assignee: Centogene GmbH
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the Diagnosis of Gaucher's Disease
    Publication number: 20220011321
    Abstract: The present invention is related to an in vitro method for diagnosing Gaucher's disease in a subject comprising a step of a) detecting a biomarker in a sample from the subject, wherein the biomarker is free lyso-Gb1.
    Type: Application
    Filed: July 20, 2021
    Publication date: January 13, 2022
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of Farber's disease
    Patent number: 11204357
    Abstract: The present invention is related to a method for diagnosing Farber's disease in a subject, wherein the method comprises detecting C26 ceramide in a sample from the subject.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: December 21, 2021
    Assignee: Centogene GmbH
    Inventors: Arndt Rolfs, Claudia Cozma
  • Method for the diagnosis of Gaucher's disease
    Patent number: 11092609
    Abstract: The present invention is related to an in vitro method for diagnosing Gaucher's disease in a subject comprising a step of a) detecting a biomarker in a sample from the subject, wherein the biomarker is free lyso-Gb1.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: August 17, 2021
    Assignee: Centogene GmbH
    Inventors: Arndt Rolfs, Hermann Mascher
  • Combination of a Compound Having the Ability to Rearrange a Lysosomal Enzyme and Ambroxol and/or a Derivative of Ambroxol
    Publication number: 20210228560
    Abstract: The present invention is related to a combination comprising a first constituent and a second constituent, wherein the first constituent is a compound having the ability to rearrange a lysosomal protein, wherein the lysosomal protein has a reduced activity, and wherein the second constituent is Ambroxol and/or a derivative of Ambroxol.
    Type: Application
    Filed: April 5, 2021
    Publication date: July 29, 2021
    Applicant: Centogene IP GmbH
    Inventors: Jan Lukas, Anahit Pews-Davtyan, Matthias Beller, Arndt Rolfs
  • Method for the diagnosis of Gaucher's disease
    Patent number: 10859580
    Abstract: The present invention is related to an in vitro method for diagnosing Gaucher's disease in a subject comprising a step of a) detecting a biomarker in a sample from the subject, wherein the biomarker is free lyso-Gb1.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: December 8, 2020
    Assignee: Centogene GmbH
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the Diagnosis of Metachromatic Leukodystrophy
    Publication number: 20200284806
    Abstract: The present invention is related to a method for diagnosing metachromatic leukodystrophy in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the sample is selected from the group consisting of blood, dried blood, serum and plasma and wherein the biomarker is different from an enzyme.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of metachromatic leukodystrophy
    Patent number: 10690682
    Abstract: The present invention is related to a method for diagnosing metachromatic leukodystrophy in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the sample is selected from the group consisting of blood, dried blood, serum and plasma and wherein the biomarker is different from an enzyme.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: June 23, 2020
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the Diagnosis of Niemann-Pick Disease
    Publication number: 20200072819
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Application
    Filed: August 15, 2019
    Publication date: March 5, 2020
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 10422789
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: September 24, 2019
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 10302664
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the biomarker is compound 509.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: May 28, 2019
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the Diagnosis of Gaucher's Disease
    Publication number: 20180259538
    Abstract: The present invention is related to an in vitro method for diagnosing Gaucher's disease in a subject comprising a step of a) detecting a biomarker in a sample from the subject, wherein the biomarker is free lyso-Gb1.
    Type: Application
    Filed: April 30, 2018
    Publication date: September 13, 2018
    Inventors: Arndt Rolfs, Hermann Mascher
  • Use of maleimide derivatives for preventing and treating cancer
    Patent number: 9993463
    Abstract: The present invention is related to a compound of formula (I) a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of cancer, wherein X is selected from the group consisting of N—R1, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and R3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: June 12, 2018
    Assignee: Centogene AG
    Inventors: Matthias Beller, Jan Lukas, Moritz Frech, Christian Junghanss, Arndt Rolfs, Anahit Pews-Davtyan
  • Method for the Diagnosis of Niemann-Pick Disease
    Publication number: 20180088107
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Application
    Filed: September 11, 2017
    Publication date: March 29, 2018
    Inventors: Arndt Rolfs, Hermann Mascher
  • Method for the diagnosis of Niemann-Pick disease
    Patent number: 9910033
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 6, 2018
    Assignee: Centogene AG
    Inventors: Arndt Rolfs, Hermann Mascher
  • Use of maleimide derivatives for preventing and treating leukemia
    Patent number: 9724331
    Abstract: The present invention is related to a compound of formula (I): a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of leukemia, wherein X is selected from the group consisting of N—R1, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and R3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 8, 2017
    Assignee: Centogene AG
    Inventors: Matthias Beller, Jan Lukas, Moritz Frech, Christian Junghanss, Arndt Rolfs, Anahit Pews-Davtyan, Christian Eisenloeffel
  • METHOD FOR THE DIAGNOSIS OF NIEMANN-PICK DISEASE
    Publication number: 20160109470
    Abstract: The present invention is related to a method for diagnosing Niemann-Pick disease in a subject comprising a step a), wherein the step a) comprises detecting a biomarker in a sample from the subject, wherein the biomarker is compound 509.
    Type: Application
    Filed: May 14, 2014
    Publication date: April 21, 2016
    Applicants: Pharm-analyt Labor GmbH, Centogene AG
    Inventors: ARNDT ROLFS, HERMANN MASCHER
  • USE OF MALEIMIDE DERIVATIVES FOR PREVENTING AND TREATING CANCER
    Publication number: 20150313882
    Abstract: The present invention is related to a compound of formula (I) a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, a metabolite thereof or a prodrug thereof; for use in a method for the treatment and/or prevention of cancer, wherein X is selected from the group consisting of N—R1, O and S; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, arylalkyl and hydrogen; R2 is selected from the group consisting of indolyl, substituted indolyl, azaindolyl and substituted azaindolyl; and R3 is selected from the group consisting of aryl, substituted aryl, unsubstituted heteroaryl, heterocyclyl and substituted heterocyclyl.
    Type: Application
    Filed: December 10, 2013
    Publication date: November 5, 2015
    Applicant: CENTOGENE AG
    Inventors: MATTHIAS BELLER, JAN LUKAS, MORITZ FRECH, CHRISTIAN JUNGHANSS, ARNDT ROLFS, ANAHIT PEWS-DAVTYAN