Patents by Inventor Arthur A. Patchett

Arthur A. Patchett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinazolinones as angiotensin II antagonists
    Patent number: 5240928
    Abstract: Novel substituted quinazolinones of the formula (I), which are useful as angiotensin II antagonists, are disclosed.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: August 31, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, Stephen E. de Laszlo, Prasun K. Chakravarty, William J. Greenlee, Arthur A. Patchett, Thomas F. Walsh
  • Substituted quinazolinones bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5238942
    Abstract: Novel substituted quinazolinones of the formula (I) are useful as angiotensin II antagonists.
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: August 24, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Dooseop Kim, Stephen E. de Laszlo, Tomasz W. Glinka
  • Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists
    Patent number: 5236928
    Abstract: There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: August 17, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Arthur A. Patchett
  • Substituted pyrimidinones bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5223501
    Abstract: Novel substituted fused pyrimidinones of formula (I) are useful as angiotensin II antagonists.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: June 29, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, Nathan B. Mantlo, William J. Greenlee, Arthur A. Patchett, Dooseop Kim
  • Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
    Patent number: 5214130
    Abstract: New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala].sup.8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: May 25, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, David Taub, Robert T. Goegelman
  • Substituted fused pyrimidinones
    Patent number: 5202328
    Abstract: Novel substituted fused pyrimidinones of formula (I), which are useful as angiotensin II antagonists, are disclosed.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: April 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Stephen E. de Laszlo, Eric E. Allen, William J. Greenlee, Arthur A. Patchett
  • Imidazole angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5183810
    Abstract: Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: February 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett, David Hangauer, Thomas F. Walsh, Kenneth J. Fitch, Ralph A. Rivero, Daljit S. Dhanoa
  • Triazole angiotensin II antagonists incorporating a substituted benzyl element
    Patent number: 5177095
    Abstract: Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 13, 1991
    Date of Patent: January 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett, David Hangauer, Wallace Ashton, Kenneth J. Fitch, Thomas F. Walsh, Ralph A. Rivero, Daljit S. Dhanoa
  • Angiotensin II antagonists incorporating a substituted indole or dihydroindole
    Patent number: 5175164
    Abstract: Substituted heterocycles attached through a methylene bridge to novel substituted indole or dihydroindole derivative of the Formula I are useful as angiotensin II antagonists.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: December 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Scott Bagley, William J. Greenlee, Daljit S. Dhanoa, Arthur A. Patchett
  • Substituted pyrimidines, pyrimidinones and pyridopyrimidines
    Patent number: 5166206
    Abstract: Substituted pyrimidines, pyrimidinones and pyridopyrimidines of formula (I) are as angiotensin II antagonists useful in the treatment of hypertension, ocular hypertension and certain CNS ailments: ##STR1## wherein K is --N(R.sup.8a)--C(.dbd.M) or --N.dbd.C(R.sup.8b) where M is O or NR.sup.22.
    Type: Grant
    Filed: March 27, 1991
    Date of Patent: November 24, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Eric E. Allen, William J. Greenlee, Malcolm MacCoss, Arthur A. Patchett
  • Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin II antagonsists
    Patent number: 5164407
    Abstract: There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: November 17, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, David B. R. Johnston, Malcolm MacCoss, Nathan B. Mantlo, Arthur A. Patchett, Prasun K. Chakravarty, Thomas F. Walsh
  • Substituted 1-(2H)-isoquinolinones bearing acidic functional groups as angiotensin II antagonists
    Patent number: 5162340
    Abstract: Substituted 1-(2H)-isoquinolinones of the structural formula: ##STR1## are angiotensin II antagonists which are useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: November 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Dooseop Kim
  • Oxo-purines as angiotensin II antagonists
    Patent number: 5157026
    Abstract: Substituted Imidazo-fused 6-membered heterocycles of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: October 20, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett, Thomas F. Walsh
  • 1-aminoethyl phosphonic acid derivatives
    Patent number: 5151521
    Abstract: New phosphonic acid derivatives are described which display antibacterial activity.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: September 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Yoshiharu Morita, Haruyuki Chaki, Yasuo Hoshide, Junko Takashima, Arthur A. Patchett
  • Angiotensin II antagonists incorporating an indole or dihydroindole
    Patent number: 5151435
    Abstract: There are disclosed substituted indoles and dihydroindoles of Formula I which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: September 29, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Scott Bagley, William J. Greenlee, Daljit S. Dhanoa, Arthur A. Patchett
  • Phosphorus containing enzyme inhibitors
    Patent number: 5147867
    Abstract: Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: September 15, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett
  • Phosphorous containing dhp enzyme inhibitors
    Patent number: 5145990
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is C.sub.2- C.sub.12 linear or branched unsubstituted alkyl; C.sub.1- C.sub.12 linear or branched substituted alkyl; C.sub.2 -C.sub.12 linear or branched monoalkenyl; C.sub.2 -C.sub.12 linear or branched alkynyl; C.sub.7 -C.sub.20 aralkyl, wherein the alkyl chain is linear or branched C.sub.1- C.sub.8 and the aryl moiety is C.sub.6- C.sub.12 ; C.sub.4- C.sub.10 cycloalkylalkyl; C.sub.3- C.sub.7 cycloalkyl; wherein these values for R.sub.1, other than C.sub.2- C.sub.12 linear or branched unsubstituted alkyl, can be substituted by one or more of C.sub.1 -C.sub.4 alkoxy, C.sub.3- C.sub.6 cycloalkyloxy, C.sub.3- C.sub.6 cycloalkylthio, C.sub.6- C.sub.12 aryloxy, C.sub.1- C.sub.4 alkylthio, C.sub.6- C.sub.12 arylthio, C.sub.7- C.sub.10 aralkyloxy, C.sub.7- C.sub.16 aralkyl-thio; and R.sub.5 is H or C.sub.1- C.sub.12 linear or branched alkyl; C.sub.2- C.sub.12 linear or branched monoalkenyl; C.sub.7- C.sub.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: September 8, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett
  • Antibacterial agents and potentiators of carbapenem antibiotics
    Patent number: 5143908
    Abstract: New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: September 1, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett, Masao Taniguchi
  • Antifungal carbazate
    Patent number: 5141954
    Abstract: A new carbazate represented by the formula ##STR1## is found to be antifungal and especially useful in the treatment of mycotic infections caused by the Cryptococcus species.
    Type: Grant
    Filed: July 30, 1991
    Date of Patent: August 25, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Frank VanMiddlesworth
  • Imidazole angiotensin II antagonists incorporating acidic functional groups
    Patent number: 5126342
    Abstract: There are disclosed substituted imidazole derivatives of Formula I which are useful as angiotensin II antagonists.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: June 30, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, William J. Greenlee, Elizabeth M. Naylor, Arthur A. Patchett, Thomas F. Walsh