Patents by Inventor Arthur A. Patchett

Arthur A. Patchett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel antibacterial agents and potentiators of carbapenem antibiotics
    Patent number: 4715994
    Abstract: New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: December 29, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett, Masao Taniguchi
  • Fluorinated amino acids
    Patent number: 4695588
    Abstract: Novel substituted .alpha.-fluoromethyl-.alpha.-amino alkanoic acids and esters thereof are disclosed. The novel compounds have biological activity including decarboxylase inhibition.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: September 22, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Arthur A. Patchett
  • Benzofused lactams useful as cholecystokinin antagonists
    Patent number: 4692522
    Abstract: Benzofused lactams and pharmaceutically-acceptable salts thereof which are useful as cholecystokinin antagonists.
    Type: Grant
    Filed: June 6, 1986
    Date of Patent: September 8, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Arthur A. Patchett
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4680392
    Abstract: The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: May 19, 1986
    Date of Patent: July 14, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Bicyclic lactams as antihypertensives
    Patent number: 4661479
    Abstract: This invention relates to bicyclic lactams and derivatives thereof which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: April 28, 1987
    Assignee: Merck and Co., Inc.
    Inventors: Matthew J. Wyvratt, Jr., Eugene D. Thorsett, Edward W. Tristram, Arthur A. Patchett, Elbert E. Harris
  • 5-amino or substituted amino imidazoles useful to treat coccidiosis
    Patent number: 4659720
    Abstract: 5-Amino or substituted amino imidazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantitites to animals, in particular to poultry, usually in admixture with animal sustenance.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: April 21, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John C. Chabala, Michael H. Fisher, Arthur A. Patchett
  • Substituted caprolactam derivatives as antihypertensives
    Patent number: 4629787
    Abstract: The invention in its broad aspects relates to caprolactam derivatives which are useful as angiotensin converting enxyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: December 16, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives
    Patent number: 4617301
    Abstract: Sulfoxide and sulfone derivatives of bicyclic lactams are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: June 22, 1983
    Date of Patent: October 14, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Matthew J. Wyvratt, Jr.
  • N-carboxymethyl substituted lysyl and .alpha.-(.epsilon.-aminoalkyl) glycyl amino acid antihypertensive agents
    Patent number: 4602002
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is --(CH.sub.2).sub.k --X--(CH.sub.2).sub.j --NHR.sup.3 ; wherein k is 0 to 3, j is 1 or 2; X is F or OH; and, R.sup.3 is hydrogen; loweralkyl or loweraralkyl which may be substituted by hydroxy, carboxy, carbamoyl, or carbalkoxy; or, acyl; and, a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: February 7, 1983
    Date of Patent: July 22, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives as antihypertensives
    Patent number: 4594341
    Abstract: There are disclosed perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives and related compounds which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: June 10, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Yak-Fa Cheung, Eugene D. Thorsett, Arthur A. Patchett
  • Substituted caprylolactam derivatives as anti-hypertensives
    Patent number: 4587238
    Abstract: The invention in its broad aspects relates to caprylolactam derivatives which are useful as angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: July 9, 1982
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett
  • Substituted enantholactam derivatives as antihypertensives
    Patent number: 4587050
    Abstract: The invention in its broad aspects relates to enantholactam derivatives which are useful as angiotensin converting enzyme inhibitors and antihypertensives.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Eugene D. Thorsett, Arthur A. Patchett
  • 3-Hydroxy-3-aminoethyl .beta.-lactams
    Patent number: 4576748
    Abstract: .beta.-Lactams of the formula: ##STR1## their preparation and use are disclosed.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: March 18, 1986
    Assignee: Merck & Co., Inc.
    Inventors: William J. Greenlee, Arthur A. Patchett
  • N.sup.2 -(Substituted)carboxymethyl-N.sup.6 -(substituted)-lysyl-and .alpha..epsilon.-aminoalkyl)glycyl amino acid antihypertensive agents
    Patent number: 4555503
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is ##STR2## wherein k is 2 to 5; R.sup.3 is hydrogen; loweralkyl and substituted loweralkyl where the substituents are carboxy, hydroxy, and amino; or aralkyl, substituted aralkyl, heteroaralkyl, and substituted heteroaralkyl where the aryl and heteroaryl substituents are carboxy, hydroxy, and amino; and C is COOR; CONH.sub.2 ; or CH.sub.2 OH; and a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: November 26, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Aminoacyl-containing dipeptide derivatives useful as antihypertensives
    Patent number: 4555502
    Abstract: The invention relates to aminoacyl-containing dipeptide derivatives and related compounds which are useful angiotensin converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: November 26, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • Dipeptides containing thialysine and related amino acids as antihypertensives
    Patent number: 4512979
    Abstract: The invention relates to dipeptide compounds containing thialysine and related amino acids which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: January 26, 1982
    Date of Patent: April 23, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Mu T. Wu
  • .alpha.-Difluoromethyl amino acids and hypertension treating compositions thereof
    Patent number: 4483870
    Abstract: Novel .alpha.-difluoromethyl tyrosines and esters thereof are disclosed. The novel compounds have useful pharmacological activity.
    Type: Grant
    Filed: August 29, 1980
    Date of Patent: November 20, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Stephen Marburg, Arthur A. Patchett
  • N-Terminal substituted oligopeptide converting enzyme inhibitors
    Patent number: 4483850
    Abstract: N-Terminal substituted oligopeptides are disclosed. The compounds are angiotensin converting enzyme inhibitors useful as antihypertensives.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: November 20, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William V. Ruyle
  • Amino acid derivatives as antihypertensives
    Patent number: 4472380
    Abstract: There are disclosed processes for preparing carboxyalkyl dipeptide derivatives and related compounds which are useful as angiotension converting enzyme (ACE) inhibitors and as antihypertensives and pharmaceutical compositions containing these carboxyalkyl dipeptide compounds in combination with another antihypertensive and/or diuretic compound.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: September 18, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, Arthur A. Patchett, Edward W. Tristram, Matthew J. Wyvratt
  • Fluorinated imidazolyl alkylamines
    Patent number: 4431817
    Abstract: Novel 1-fluoromethyl-substituted alkyl amines are disclosed. The novel compounds have biological activity including decarboxylase inhibition.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: February 14, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, Janos Kollonitsch