Abstract: A syringe assembly may include a syringe having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end and defining an interior volume; and an indicator float provided in the interior volume of the syringe. The indicator float may be buoyant such that the indicator float is movable between the distal end and the proximal end of the syringe based on a fluid fill level within the interior volume of the syringe.

Abstract: Methods and systems for diluting a dose of a substance to be delivered to a patient and for determining a maximum deliverable dose of the substance and/or a partial fluid volume to be delivered to the patient to provide a desired dose amount are provided. The method includes the step of providing a first substance within a fluid reservoir having an initial unit value. The method also includes diluting the first substance with a second substance to produce the diluted solution. Once the first substance is diluted, a total volume (VTotal) of the diluted solution is measured. A concentration of the diluted solution is then calculated based on the initial unit value and the total volume (VTotal). A fluid delivery system including a fluid reservoir and fluid delivery device, which is configured to perform the method, is also provided.

Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Abstract: A medical injector including at least one syringe port for engaging at least one syringe and having a locking mechanism. The locking mechanism enables the syringe to self-align with the syringe port for locking engagement upon insertion of the syringe into the syringe port and to axially eject the syringe from the port upon rotational disengagement of the syringe from the port.

Abstract: A pressure jacket for use with a fluid injector may have a pressure jacket body having a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a pressure jacket longitudinal axis. The pressure jacket may further have at least one resiliently deflectable retaining member having a first segment attached to the pressure jacket body and a second segment protruding from the first segment toward the distal end of the pressure jacket body and deflectable relative to the first segment. The pressure jacket may further have at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member may interact with a housing of the fluid injector when the pressure jacket is connected to the housing to deflect the at least one resiliently deflectable retaining member upon rotation of the pressure jacket.

Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.

Abstract: Described is an in-scan phantom for use during an imaging procedure. The phantom can include at least one measuring insert and/or at least one measured insert. The measuring insert may have radiation detecting capabilities while the measured insert may include a radioactive material. Also described is an imaging modality system that includes an imaging modality and an in-scan phantom as well as methods of using the in-scan phantom for imaging a patient or performing a scout scan.

Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.

Abstract: An infusion system includes a double action infusion pump. The pump includes a cylinder and a reciprocating piston received within the cylinder, the reciprocating piston separating a first pump chamber from a second pump chamber of the cylinder. A reciprocating motor is coupled with the reciprocating piston, and the first and second pump chambers alternate between filling and evacuating conditions with reciprocation of the reciprocating piston through operation of the reciprocating motor, and the speed of reciprocation is varied to provide a continuous output of fluid between the first and second pump chambers. A fluid source and a catheter are optionally coupled with the double action infusion pump. The catheter includes one or more infusion ports near a catheter distal portion, and the one or more infusion ports receive and expel the continuous output of fluid from the double action infusion pump.

Abstract: A diagnostic contrast composition includes a carrier fluid and a non-decaying gas-evolving fluid incorporated in the carrier fluid. The gas-evolving fluid has a vapor pressure sufficient to evolve the gas from a circulatory system within a lung of a patient. The gas-evolving fluid is a composition containing a sufficient quantity of atoms with an atomic number higher than 8 to provide an increased absorption sufficient to increase a Hounsfield Unit measurement in an image in a CT imaging system. The gas-evolving fluid is selected from the group consisting of xenon gas, krypton gas, sulfur hexafluoride, a perfluorocarbon, a brominated perfluorocarbon, and combinations thereof. The carrier fluid is selected from the group consisting of water, saline, saline comprising one or more blood proteins, and saline comprising dissolved lipids.

Abstract: Methods and systems for controlled administration of a tracer and quantification of uptake of the tracer by a target organ are described. The method includes administering a tracer to a patient and imaging at least two regions of the patient's body that cannot be imaged simultaneously. An input function for the tracer can be determined by imaging a first region of the patient's body during selected times, and using an injector to administer the tracer in a manner that accurately estimates the input function when this first region is not being imaged. One or more additional regions of the body may then be imaged to create data that may be used to estimate the input function. One or more parameters may then be estimated from each additional region of the body based on the input function and the imaging data gathered from each region.

Abstract: A system and method for determining the fill volume of a fluid chamber includes a fluid injector, at least one fluid chamber in fluid communication with the fluid injector, one or more sensors positioned relative to the at least one fluid chamber and configured to detect a position of a liquid-gas interface of the fluid contained in the at least one fluid chamber, and at least one processor in communication with the sensors and the fluid injector, and configured to: determine the position of the liquid-gas interface of the fluid, calculate the volume of fluid in the at least one fluid chamber based on the position of the liquid-gas interface, and at least one of: i) display the volume of the fluid; ii) enable the fluid injector to perform an action; and iii) disable the fluid injector from performing the action.

Abstract: A pressure jacket for use with a fluid injector includes a barrel having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end along a longitudinal axis. The pressure jacket includes at least one engagement member protruding from a terminal portion of the proximal end of the barrel in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end of the barrel. The at least one engagement member engages with a locking mechanism on the fluid injector to releasably lock the pressure jacket with the fluid injector. A taper of the at least one engagement member rotationally guides the barrel into self-alignment with the locking mechanism and axially ejects the barrel upon rotation of the barrel about the longitudinal axis.

Abstract: A pressure jacket includes a barrel having a proximal end, a distal end, and a sidewall extending substantially circumferentially between the proximal end and the distal end along a longitudinal axis. The pressure jacket also includes at least one retaining member having at least one first lug protruding radially outward relative to an outer surface of the sidewall. The at least one first lug has at least one third surface tapered axially relative to the longitudinal axis of the barrel in a proximal direction. The at least one first lug is configured for engagement with a locking mechanism associated with a port on a fluid injector to releasably lock the pressure jacket with the fluid injector. At least a portion of the at least one third surface axially ejects the pressure jacket upon rotation of the pressure jacket about the longitudinal axis.

Abstract: A connector assembly for a fluid delivery system includes a conical body defining an interior cavity and a discharge outlet, the discharge outlet defining an internal passage in fluid communication with the interior cavity; and a connector removably attached to the discharge outlet. The connector includes a central body configured to be at least partially positioned within the internal passage of the discharge outlet, and an annular connector portion connected to the central body and configured to releasably engage an exterior of the discharge outlet, the central body defining an internal channel within the central body that is in fluid communication with the interior cavity of the conical body when the connector is attached to the discharge outlet.

Abstract: A system for delivering to a patient a slurry which includes a fluid and a material that is non-dissolvable or immiscible in the fluid. The system includes a container adapted to contain the slurry and a supernate of the slurry, a syringe adapted to contain the slurry after dilation with the supermate, a fluid path between the syringe and the contents of the container, the fluid path including a needle at least partially disposed within the contents of the container, a plunger disposed in the syringe and adapted to create pressure in the syringe to cause a dilated slurry to flow into the syringe through the fluid path, and a fluidizing systen associated with the container and comprising a holder adapted to move the needle within the container to affect dilation of the slurry with a portion of the supernate.

Abstract: A medical injector including at least one syringe port for engaging at least one syringe and having a locking mechanism. The locking mechanism enables the syringe to self-align with the syringe port for locking engagement upon insertion of the syringe into the syringe port and to axially eject the syringe from the port upon rotational disengagement of the syringe from the port.

Abstract: Vial containers including a collar which is attached to a vial or incorporated into a vial cap, a cap designed to receive a portion of the collar while covering the vial, and a container designed to receive a portion of the collar and encase the body of the vial are described herein. The collar, generally, includes a means for reversibly attaching to the cap and container.