Abstract: A syringe shield useful for containing a syringe loaded with radioactive and/or light sensitive drugs is disclosed. The syringe shield may reduce a healthcare provider's exposure to radiation and/or may reduce or eliminate ambient light contamination to optically sensitive components in the syringe.

Abstract: A syringe includes a barrel having a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end along a longitudinal axis. At least one syringe retaining member protrudes radially outwardly relative to an outer surface of the sidewall. The at least one syringe retaining member tapers axially in a direction from the distal end toward the proximal end. The at least one syringe retaining member is configured for selective engagement with a locking mechanism on a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one syringe retaining member is configured to rotationally guide the syringe into alignment with the locking mechanism.

Abstract: An integrated radiopharmaceutical patient treatment system includes a portable radioisotope generation module configured to generate a gaseous radioisotope, a radiopharmaceutical processing module configured to dissolve the radioisotope in an injectable medical fluid, a fluid injection system in fluid communication with the radiopharmaceutical processing module and configured to inject a dose including the radioisotope and the injectable medical fluid into a patient, and at least two imaging devices configured to independently detect biological and physiological characteristics of the patient based on the dose. The radiopharmaceutical processing module may be in fluid communication with the radioisotope generation module.

Abstract: A syringe is provided including an orientation independent indicia that can be used to validate and determine information about the syringe, injection parameters, and/or fluid contained therein. The syringe includes a syringe barrel and an indicia located on a portion of the syringe containing or associated with identifying information about the syringe, one or more injection parameters of a fluid injector, or a fluid filled in the syringe barrel. The indicia is readable by a reader independent of an orientation of the syringe relative to the reader. A fluid injection system for providing fluid into a patient is also provided. The injection system includes the syringe having an orientation-independent indicia, an injector having at least one syringe receiving port for receiving the syringe, and a controller. The controller can be configured to obtain information from the indicia and provide instructions for performing injections to the injector, based on the information.

Abstract: A fluid path set for use with an injection device has a single-patient disposable set and a patency check device. A proximal end of the single-patient disposable set is configured for connecting with the injection device. The patency check device has a proximal end configured for connecting with a distal end of the single-patient disposable set and a distal end configured for connecting with a patient fluid delivery device. The patency check device has a body extending between the proximal end and the distal end. The body has a reversibly expandable interior chamber configured for drawing fluid through the patient fluid delivery device during a patency check. The patency check device further has a locking mechanism configured for controlling the volume of the interior chamber during an injection procedure.

Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engagable with the piston regardless of a rotational orientation of the piston relative to the plunger.

Abstract: A syringe assembly may include a syringe having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end and defining an interior volume; and an indicator float provided in the interior volume of the syringe. The indicator float may be buoyant such that the indicator float is movable between the distal end and the proximal end of the syringe based on a fluid fill level within the interior volume of the syringe.

Abstract: A container adapted to store and transport an injectate is disclosed. The container includes a divider which extends from an open top end toward a closed bottom end, the divider spaced apart from the closed bottom end to define an opening and separating the container into a first fluid path on a first side of the divider through which fluid can enter the container through the inlet port and a second fluid path on a second side of the divider through which fluid can enter the opening and exit the container through the outlet port. The second fluid path includes at least one filter between the opening and the open top end through which fluid can pass from the first fluid path to the second fluid path but through which at least one component of the injectate cannot pass.

Abstract: Syringe systems and flow control systems configured to detect information associated with a liquid material are described. The syringe systems may include a syringe body for housing the liquid material and an injector piston for expelling the liquid material out of the syringe through a discharge outlet at a distal end of the syringe body. Components of the syringe, such as an injector piston, may include sensors configured to measure and/or detect a property of the liquid material, such as concentration, pH, or radioactivity. The flow control system may include a pinch valve and a platen arranged about a fluid delivery channel. Flow within the fluid delivery channel may be controlled by increasing (squeezing the fluid delivery channel) or decreasing the distance between the pinch valve and the platen. Components of the flow control system may include detectors configured to detect properties of fluid in the fluid control channel.

Abstract: A method and system for tailoring an injection protocol to an individual patient, wherein the injection protocol is administered in connection with a diagnostic imaging procedure. The method includes: administering a test injection of a fluid including a contrast enhancing fluid into the patient at an administration site; performing a test scan of one or more regions of interest of the patient as the fluid propagates through the patient to obtain scan data; determining from the scan data an enhancement output from each of the one or more regions of interest at a plurality of points in time as a result of the propagation of the fluid through the patient; and determining the injection protocol for the patient based at least in part upon the enhancement output from each of the one or more regions of interest at each of the plurality of points in time.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range.

Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

Abstract: A multi-dose disposable fluid delivery system includes at least one fluid container, a multi-use fluid path set, and a plurality of single-use fluid path sets. The at least one fluid container has a connection port configured for fluidly connecting with a first end of the multi-use fluid path set. The second end of the multi-fluid path set is configured for fluidly connecting to a fluid injection apparatus. The plurality of single-use fluid path sets is connected in sequence to define a fluid path extending from a first single-use fluid path set to a last single- use fluid path set. Each of the plurality single-use fluid path sets has a first end and a second end. The first end of the first single-use fluid path set is configured for connecting to a delivery line. The second end of the last single-use fluid path set is configured for connecting to the injection apparatus.

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract: A catheter including an outer conduit and an inner conduit positioned within the outer conduit, the inner conduit having a smaller diameter that that of the outer conduit. A volume between the outer conduit and the inner conduit define a first lumen which may deliver a first fluid to a patient, and an inside diameter of the inner conduit defines a second lumen which may deliver a second fluid to the patient such that the fluid flow of the first fluid and the second fluid exiting the catheter has a flow profile where the first fluid surrounds the second fluid and the second fluid is prevented from contact with inner walls of a blood vessel of the patient in a vicinity of a tip of the catheter.

Abstract: Methods and systems for controlled administration of a tracer and quantification of uptake of the tracer by a target organ are described. The method includes administering a tracer to a patient and imaging at least two regions of the patient's body that cannot be imaged simultaneously. An input function for the tracer can be determined by imaging a first region of the patient's body during selected times, and using an injector to administer the tracer in a manner that accurately estimates the input function when this first region is not being imaged. One or more additional regions of the body may then be imaged to create data that may be used to estimate the input function. One or more parameters may then be estimated from each additional region of the body based on the input function and the imaging data gathered from each region.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.

Abstract: A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engagable with the piston regardless of a rotational orientation of the piston relative to the plunger.