Patents by Inventor Arthur L. Babson

Arthur L. Babson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130344515
    Abstract: A radial flow immunoassay includes a membrane having a plurality of immobilized distinct antigens disposed thereon. Methods of producing the immunoassay, and methods of utilizing same to detect immunoglobulin present in a biological sample, are also disclosed.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 26, 2013
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventor: Arthur L. Babson
  • Patent number: 8215821
    Abstract: A test vessel agitator assembly that agitates test vessels and the contents therein within an immunoassay automated analyzer system. The test vessels are transported along an element that is comprised of ridges and troughs such that the test vessel is moved in a directions that is approximately perpendicular to the direction of transportation.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: July 10, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri
  • Publication number: 20110275095
    Abstract: Biological samples are assayed for the presence of IgE antibodies specific to unknown allergens in the samples. Known allergens conjugated to biotin are attached as an array of spots on a streptavidin-linked membrane. A sample is incubated with the membrane containing attached known allergens. After washing away excess sample, the membrane is contacted with a labeled anti-IgE, e.g. alkaline phosphatase-labeled anti-IgE, thus attaching anti-IgE to the IgE from the sample, now bound to known allergens. The excess labeled anti-IgE is washed away and the attached IgE remaining on the membrane identified by adding a substrate for the label, thus producing a measurable response.
    Type: Application
    Filed: January 14, 2010
    Publication date: November 10, 2011
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventor: Arthur L. Babson
  • Patent number: 7670553
    Abstract: An automated chemical or biological sample analyzer includes a plurality of linear sample carrying racks that are moved to a processing station for conducting an analysis using one or more carousel devices. Under computer control, rotational movements of the carousel or carousels, linear movements of the transfer or shuttle mechanisms, and operation of a pipetting station are performed in a coordinated fashion so as to handle the processing of a large number of samples simultaneously in an optimized fashion that allows random ordering of samples for processing.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: March 2, 2010
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Arthur L. Babson
  • Patent number: 7175334
    Abstract: A test vessel agitator assembly that agitates test vessels and the contents therein within an immunoassay automated analyzer system. The test vessels are transported along an element that is comprised of ridges and troughs such that the test vessel is moved in a directions that is approximately perpendicular to the direction of transportation.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: February 13, 2007
    Assignee: DPC Cirrus, Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri
  • Patent number: 6849457
    Abstract: A bead dispenser device useful for supplying, one at a time, beads for heterogenous immunoassay, including an inner chamber having a return spring integrally formed to the inner chamber. The bead device also includes a plunger housed within a plunger chamber. The plunger includes a bead holding member and a notch. The return spring communicates with the notch of the plunger and biases the plunger in a resting position. In the resting position, the bead holding member is aligned with a bead receiving channel formed partly in the base of the inner chamber. When the plunger is depressed, the bead residing in the bead holding member is transported to a bead exit opening for dispensing therefrom. In this position, the return spring is also displaced inward to an inner portion of the inner chamber and is capable of agitating and contacting the beads located within the inner chamber.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: February 1, 2005
    Assignee: DPC Cirrus, Inc.
    Inventors: Arthur L. Babson, Ilya Malyarov
  • Patent number: 6417008
    Abstract: A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: July 9, 2002
    Assignee: DPC Cirrus, Inc.
    Inventors: William Tyberg, Arthur L. Babson
  • Publication number: 20010028864
    Abstract: A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.
    Type: Application
    Filed: May 1, 2001
    Publication date: October 11, 2001
    Inventors: William Tyberg, Arthur L. Babson
  • Patent number: 6270726
    Abstract: A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: August 7, 2001
    Assignee: DPC Cirrus, Inc.
    Inventors: William Tyberg, Arthur L. Babson
  • Patent number: 5885529
    Abstract: An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: March 23, 1999
    Assignee: DPC Cirrus, Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri, Anthony P. Montalbano, Chris P. Montalbano, Greg A. Montalbano, Eric C. Fleischer
  • Patent number: 5885530
    Abstract: An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: March 23, 1999
    Assignee: DPC Cirrus, Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri, Anthony P. Montalbano, Chris P. Montalbano, Greg A. Montalbano, Eric C. Fleischer
  • Patent number: 5723092
    Abstract: A sample dilution system including a dilution well waste chamber chamber, a dilution well spinning device, and a dilution well adapted to be controllably rotated by the dilution well spinning device when positioned within the dilution well chamber. The dilution well used in the dilution well system has an outer splash guard and a distal tip to permit facile tube gripping, respectively, and inner fins (baffles) to effect rapid and efficient mixing of the fluid contents of the dilution well.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: March 3, 1998
    Assignee: DPC Cirrus Inc.
    Inventor: Arthur L. Babson
  • Patent number: 5721141
    Abstract: A tube washing system including a tube spinning station having a rotatable chuck and a waste chamber surrounding the chuck for capturing and draining tube fluids expelled from a spun tube driven in rotation by the chuck. The chuck has a body portion and a plurality of spaced apart teeth defining intervening grooves extending through the body portion with at least one of the grooves permitting passage of fluid through the body portion and at least one other of the grooves receives and mechanically connects a projection on an open end of a tube. A pipette for dispensing wash water into a tube is located centrally within the chuck. There is also a tube elevating device located beneath the tube spinning station, the tube elevating device comprising a freely rotatable tube holder, and lift drive motor provided to vertically move the tube holder towards and way from the chuck. The tube used in the washing system has at least one projection provided on its open end which can interlock with a chuck groove.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: February 24, 1998
    Assignee: DPC Cirrus Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri
  • Patent number: 5632399
    Abstract: Self-sealing reagent container, and a system of same on a carousel, related to a vessel having a plurality of separate compartments, each compartment having an opening in an upper surface of the vessel, with a hinged lid member attached to said vessel having spring-like biasing to automatically reseal openings of the vessel after reagent extraction. The lid has a first arm that is normally biased such that its caps cover the compartment openings, but external force can be applied to said first arm to permit the first arm to be translated so as to displace the caps from covering the compartment openings whereby reagent in the compartments can be accessed and withdrawn. Once the reagent extraction is completed and the compartment opening cleared of the extraction device, the normal biasing acting on the first arm of the lid causes it to move back to reseal the caps over the compartment openings.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: May 27, 1997
    Assignee: DPC Cirrus Inc.
    Inventors: Thomas Palmieri, Arthur L. Babson
  • Patent number: 5318748
    Abstract: A centrifuge vessel (10) for performing automated immunoassays is disclosed. The centrifuge vessel (10) comprises a center tube (11) and an outer waste chamber (15). A biomaterial (18) is held within the center tube (11) and is capable of binding specific analytes in test samples. In operation, the centrifuge vessel (10) is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube (11) to be transported into the outer waste chamber (15) while the analyte of interest remains bound to the biomaterial (18) positioned within the center tube (11).
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: June 7, 1994
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Babson, John E. Underwood
  • Patent number: 5316726
    Abstract: An automated immunoassay analyzer includes a computer controlled instrument (10) and display (16). The display (16) provides a real-time presentation of all operations being performed within the instrument (10). A large number of samples can be loaded into the instrument (10), and the order of testing the samples can be rearranged according to a priority determined by the operator at any time. A wide variety of immunoassays can be performed on each sample and several different immunoassays can be performed on any one sample. Information related to the type of immunoassays being performed on particular samples is collected by a bar code reader (44) and this information is conveyed to the computer (12) for presentation on the display (16). The computer (12) tracks the progress of each immunoassay through the reaction circuit to the detection station (46).
    Type: Grant
    Filed: December 4, 1992
    Date of Patent: May 31, 1994
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Babson, Arthur F. Ross, Douglas R. Olson, Gershon Giter, Victor R. Huebner
  • Patent number: 5258309
    Abstract: A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed by flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: November 2, 1993
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Babson, John E. Underwood
  • Patent number: 5149501
    Abstract: An instrument (50) automatically determines the concentrations of HDL cholesterol, LDL cholesterol, total cholesterol and triglycerides for a sample (80) of whole, anticoagulated blood placed in a doughnut shaped container (10). The sample (80) is first separated into its blood cell and plasma (84) constituents using high speed centrifugation (54) and a thixotropic gel (82). Part of the plasma (84) is then deposited in an HDL separation chamber (14) where LDL cholesterol and VLDL cholesterol are precipitated by a reagent and the precipitant is sedimented by high speed centrifugation (54) against V-shaped grooves (40) in the outermost wall (38) of the HDL separation chamber (14). Part of the plasma (84) is diluted ten-fold. The supernatant in the HDL separation chamber is then placed in a cuvette reaction chamber (b 18) where it reacts with a cholesterol reagent. The diluted plasma is placed in two other cuvette reaction chambers (18) where it reacts with chloesterol and triglycerides reagents, respectively.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: September 22, 1992
    Assignee: Cirrus Diagnostics, Inc.
    Inventors: Arthur L. Babson, Thomas Palmieri, Douglas R. Olson
  • Patent number: 5098845
    Abstract: A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed byl flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: March 24, 1992
    Assignee: Cirrus Diagnostics, Inc.
    Inventor: Arthur L. Babson
  • Patent number: 5084240
    Abstract: A centrifuge vessel (10) for performing automated immunoassays is disclosed. The centrifuge vessel (10) comprises a center tube (11) and an outer waste chamber (15). A biomaterial (18) is held within the center tube (11) and is capable of binding specific analytes in test samples. In operation, the centrifuge vessel (10) is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube (11) to be transported into the outer waste chamber (15) while the analyte of interest remains bound to the biomaterial (18) positioned within the center tube (11).
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: January 28, 1992
    Assignee: Cirrus Diagnostics Inc.
    Inventor: Arthur L. Babson