Abstract: The present invention relates generally to a unique vessel for separating a liquid from a solid phase in a single and convenient unit and, more particularly to a reaction vessel which may be used for conducting a number of different chemical and immunoassay methodologies.

Abstract: Disclosed is a uniquely simple, multiple use apparatus for the packaging of fluids, such as those reference fluids used for the calibration and standardization of blood gas instrumentation, which must not be exposed to air.

Abstract: This invention relates to a method for the removal of heparin from heparin-containing plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

Abstract: An immunoassay wherein the sample containing an immunologic substance is added to a suspension of particles coated with a second immunologic substance which is specific to the immunologic substance of the sample. The change in percentage of light transmission through the suspension undergoing the resulting agglutination is measured for a predetermined period of time and compared to a standard graph. The suspension is under constant agitation during the measurement.

Abstract: This invention relates to a method for the removal of heparin from heparin-containing blood plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

Abstract: A blood collection assembly and closure therefor, for the collection, separation, isolation and storage of serum from blood. The closure is constructed of a cannula penetrable self-sealing elastomer and includes a thixotropic barrier material in a hollow central portion of the closure, so that the barrier material is sealed within the closure until blood has been collected in the collection container and centrifuged. Centrifugation forces the barrier material into a collecton container through the passageway created by the cannula.

Abstract: The specific disclosure provides a device and method of making an incision of precise dimensions in a patient, preferably in the forearm, and determining exact bleeding from initial puncture of the skin until the flow of blood has ceased, i.e. hemostatis is complete. The device comprises a housing including a blade aperture at one end thereof adapted to be positioned in abutting engagement with the skin of the subject. A spring member and a blade member having at least one cutting edge are located in the housing. Means are also provided in the housing and is connected to the blade member for retracting the blade member inwardly from the blade aperture and against the bias of the spring member. Manually operable means are provided for releasably engaging the retracting means to maintain the blade member in a retracted position against the bias of the spring member until the device is ready for use.

Abstract: This invention relates to a system for the identification of bacteria which comprises a series of punched cards, each card representing a different biochemical test.

Abstract: The present invention relates to an improved process for the production of a deficient citrated plasma useful in the clinical laboratory as a control plasma for the testing of clotting function, and particularly, in patients who are on oral anticoagulant thereapy.